Preparing of pellets by extrusion/spheronization using different types of equipment and process conditions

Bölcskei, Éva; Regdon, Géza; Sovány, Tamás; Ghanam, Dima; Knop, Klaus; Kleinebudde, Peter; Pintye‐Hódi, Klára

doi:10.3109/03639045.2013.783588

Cited by 5 publications

(3 citation statements)

References 9 publications

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“…The extrusion/spheronization process is commonly used in the pharmaceutical industry to make uniformly sized pellets (Setthacheewakul et al, 2011). Pellet, as a multiple unit dosage form, possess many advantages such as flexibility of manufacture, reducing intrasubject and intersubject variability of plasma profiles and minimizing GI irritation without lowering drug bioavailability (Gandhi et al, 1999;Bolcskei et al, 2013). Thus, it is very appealing to combine the advantages of pellets with those of SEDDS.…”

Section: Single-pass Intestinal Perfusionmentioning

confidence: 98%

Self-emulsifying drug delivery system and the applications in herbal drugs

Zhang

et al. 2013

Drug Delivery

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Herbal drugs have been used for thousands of years in the east and have had a recent resurgence in popularity among consumers in the west. However, most of herbal drug are poorly soluble and have hydrophobic properties and poor distribution, leading to reduced bioavailability and hence decreased treatment efficacy, requiring repeated administration or increased dose. In the past few decades, considerable attention has been focused on the development of self-emulsifying drug delivery system (SEDDS) for herbal drugs. SEDDS is isotropic and thermodynamically stable solutions consisting of oil, surfactant, co-surfactant and drug that can spontaneously form oil-in-water micro/nanoemulsion when mixed with water under gentle stirring. The formulation can be a viable alternative to classical formulations to take advantage of their lipophilic nature and to solve their problems of poor solubility, poor bioavailability, low oral absorption and instability. The mechanism of self-emulsification, solubility studies, construction of phase diagram, optimization and characterization of herbal drugs-loaded SEDDS formulation and in situ absorption evaluation of herbal drugs in rat intestine are presented in our article.

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Section: Single-pass Intestinal Perfusionmentioning

confidence: 98%

Self-emulsifying drug delivery system and the applications in herbal drugs

Zhang

et al. 2013

Drug Delivery

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“…These differences in the extrudates further impacted the pellet size and other physical properties of the pellets. It has been demonstrated that the spheronization speed and time impacted the size of the produced pellets (74). An increase in the speed of the Spheronizer resulted in a decrease in the pellet size.…”

Section: Process Related Challenges In Extrusion -Spheronization Tech...mentioning

confidence: 99%

Quality aspects in the development of pelletized dosage forms

Agrawal

Fernandes

Shaikh

et al. 2022

Heliyon

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“…Water is the most important variable as extrusion process variables. Moisture content has a signi ficant impact on spheres quality [47]. Less moisture content in pellets causes the generation of fines with large variation in pellet size distribution.…”

Section: Moisture Contentmentioning

confidence: 99%

An Outline of Variables in Pelletization by Extrusion and Spheronization

Mishra¹,

Paldewar²,

Nandgude³

2020

Int J App Pharm

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Pelletization is an agglomeration process which converts fine granules or powders of bulk drugs into small, free-flowing, spherical units, known as pellets. The pelletization can be achieved either through agitation, compaction (extrusion-spheronization), drug layering and globulation. Among the various pelletization techniques extrusion–spheronization process is preferred over other methods for the preparation of pellets as it allows the incorporation of the higher amount of drug, modified physical characteristics of the drug (density, sphericity, narrow size distribution, smoother surface) and multiple drugs can be easily combined in the same unit. This current review summarizes the findings or investigations by the researchers on various variables, including process parameters, equipment parameters and formulation parameters influencing the quality of pellets. The article also focuses on process optimization and additives used in pellets formulation. To prepare the current review search criterion used was the parameters affecting final pellet characterization in the extrusion spheronization process. The sources were peer-reviewed relevant scientific articles of recognized journals. Keywords used as filters were extrusion, spheronization, formulation parameters, process parameters, equipment parameters, moisture content, granulating liquid, drying rate, extrusion temperature, spheronizer load, pelletization. Literature survey has been done in a range of years (1992-2019) regarding the various variables of the extrusion spheronization process, which affects and has foremost impact on the final quality of pellets so as to make the review updated and comprehensive.

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Preparing of pellets by extrusion/spheronization using different types of equipment and process conditions

Abstract: Pellets from both processes were similar in shape and tensile strength. They differed in particle size and dissolution profile. This may be contributed to different spheronization conditions.

Cited by 5 publications

References 9 publications

Self-emulsifying drug delivery system and the applications in herbal drugs

Self-emulsifying drug delivery system and the applications in herbal drugs

Quality aspects in the development of pelletized dosage forms

An Outline of Variables in Pelletization by Extrusion and Spheronization

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