Preparing for the Unexpected

Koblin, Beryl A.; Andrasik, Michele P.; Austin, Judy

doi:10.1097/qai.0b013e31829a3a4d

Cited by 23 publications

(6 citation statements)

References 40 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Baseline STI prevalence were compared between gender subgroups by Barnard's exact test. As risk reduction was anticipated to be greatest by the first post-baseline assessment [11][12][13], STI prevalence was compared at month 0 and month 6 (month 12 for syphilis) using generalized estimating equations with logit link and independent correlation structure to model the binary outcome of presence of an STI (yes/no). Descriptive rather than inferential statistics were reported for STI prevalence at the later time points due to the higher rates of missing data.…”

Section: Discussionmentioning

confidence: 99%

Sexually transmitted infections amongst men who have sex with men (MSM) in South Africa

Mashingaidze

Moodie

Allen

et al. 2023

PLOS Glob Public Health

View full text Add to dashboard Cite

There is limited data about bacterial STIs in MSM populations in sub-Saharan Africa. Our retrospective analysis used data from the HVTN 702 HIV vaccine clinical trial (October 2016 to July 2021). We evaluated multiple variables. Polymerase chain reaction testing was conducted on urine and rectal samples to detect Neisseria gonorrhoea (NG) and Chlamydia trachomatis (CT) every 6 months. Syphilis serology was conducted at month 0 and thereafter every 12 months. We calculated STI prevalence and the associated 95% confidence intervals until 24 months of follow-up. The trial enrolled 183 participants who identified as male or transgender female, and of homosexual or bisexual orientation. Of these, 173 had STI testing done at month 0, median age was 23 (IQR 20–25) years, with median 20.5 (IQR 17.5–24.8) months follow-up (FU). The clinical trial also enrolled and performed month 0 STI testing on 3389 female participants, median age 23 (IQR 21–27) years, median 24.8 (IQR 18.8–24.8) months FU and 1080 non-MSM males with a median age of 27 (IQR 24–31) years, median 24.8 (IQR 23–24.8) months FU. At month 0, CT prevalence was similar in MSM and females (26.0% vs 23.0%, p = 0.492) but was more prevalent in MSM compared to non-MSM males (26.0% vs 14.3%, p = 0.001). CT was the most prevalent STI among MSM at months 0 and 6 but declined from month 0 to month 6 (26.0% vs 17.1%, p = 0.023). In contrast, NG did not decline in MSM between months 0 and 6 (8.1% vs 7.1%, p = 0.680) nor did syphilis prevalence between months 0 and 12 (5.2% vs 3.8%, p = 0.588). Bacterial STI burden is higher in MSM compared to non-MSM males, and CT is the most prevalent bacterial STI amongst MSM. Preventive STI vaccines, especially against CT, may be helpful to develop.

show abstract

Section: Discussionmentioning

confidence: 99%

Sexually transmitted infections amongst men who have sex with men (MSM) in South Africa

Mashingaidze

Moodie

Allen

et al. 2023

PLOS Glob Public Health

View full text Add to dashboard Cite

show abstract

“…South Africa (SA) carries 16% of the global burden of Human Immunodeficiency Virus (HIV), with an HIV prevalence of 12% (1). In HIV prevention trials-including vaccines, oral or injectable Pre-Exposure Prophylaxis (PrEP), and microbicidesidentifying HIV exposure through sexual activity is an ongoing challenge (2)(3)(4)(5). In the absence of a biological marker to identify actual HIV exposure, retrospective self-reported risky sexual behavior is usually used as a proxy of potential exposure to infection.…”

Section: Introductionmentioning

confidence: 99%

“You Are on the Right Track With the App:” Qualitative Analysis of Mobile Phone Use and User Feedback Regarding Mobile Phone Sexual Risk Assessments for HIV Prevention Research

Dietrich

Benadé

Mulaudzi

et al. 2021

Front. Digit. Health

View full text Add to dashboard Cite

Background: Accurate self-report of sexual behavior assists in identifying potential HIV exposure in HIV prevention trials. Brief mobile phone assessments, completed daily or after sexual activity, can improve the validity and reliability of self-reported sexual behavior and allow for remote survey completion outside of the clinic setting. We conducted a qualitative study to better understand participants mobile phone use and to explore their perspectives on how to improve an existing mobile application-based sexual risk assessment.Methods: Sexually active, HIV seronegative men (n = 14) and women (n = 15) aged 18–39 years were recruited through an HIV counseling and testing clinic and community outreach in Soweto, South Africa. We conducted qualitative research through four age-stratified focus group discussions (FGDs) and analyzed a brief socio-demographics and mobile phone access questionnaire. All participants completed a sexual risk assessment before the FGD. Using a framework analytic approach, data were coded with Nvivo software.Results: All participants had access to mobile phones and internet, and 27 (93.1%) were able to download applications on their personal phones. Participants preferred mobile risk assessments to be offered in a choice of South African languages, using formal language (as opposed to emojis), with straight-forward wording and limited to five to 10 questions. Most participants found it acceptable to complete the assessment once a week, on a weekday, while a few were willing to complete it after each sexual encounter. It was suggested that a message reminder to complete the assessment should be sent at least daily until it is completed. The majority agreed that a password-protected application with a discreet logo was ideal for privacy, ease of use and flexibility for completion in any setting. A concern with this format, however, was the potential data use requirement. Participants expressed privacy concerns with using SMS, WhatsApp and other social media for risk assessments. Most agreed on an airtime incentive between ZAR5-10 (USD 0.29–0.58) per survey. Participants encouraged researchers to provide feedback to them about their sexual risk.Conclusions: Completion of mobile phone sexual risk assessments can be optimized with minimal incentives by ensuring that questionnaires are simple, brief, infrequent and have trusted privacy measures.

show abstract

“…Methodologically, these findings have prompted a call for more objective adherence measures, including real-time assessments that could be implemented alongside novel interventions to increase adherence (9, 13, 14). Their interpretation has informed several hypotheses proposed to explain the apparent low adherence found in some trials that, notably, achieved high study retention overall despite intensive study visit schedules.…”

Section: Introductionmentioning

confidence: 99%

Pre-exposure Prophylaxis Adherence Measured by Plasma Drug Level in MTN-001: Comparison Between Vaginal Gel and Oral Tablets in Two Geographic Regions

et al. 2015

View full text Add to dashboard Cite

Despite strong evidence that daily oral pre-exposure prophylaxis (PrEP) reduces HIV risk, effectiveness across studies has varied. Inconsistent adherence constitutes one explanation. Efforts to examine adherence are limited when they rely on self-reported measures. We examined recent adherence as measured by plasma tenofovir (TFV) concentration in participants of MTN-001, a phase 2 cross-over trial comparing oral tablet and vaginal gel formulations of TFV among 144 HIV-uninfected women at sites in the United States (US) and sub-Saharan Africa (SSA). Adherence to daily product use was higher in the US than in the SSA sites. Within region, however, adherence was similar between products. In the US, gel adherence was higher among married women, and lower among women using male condoms and injectable contraceptives. At the SSA sites, gel adherence was lower for younger women. Inconsistent adherence points to challenges in use of daily PrEP, even during a trial of short duration.

show abstract

Preparing for the Unexpected

Cited by 23 publications

References 40 publications

Sexually transmitted infections amongst men who have sex with men (MSM) in South Africa

Sexually transmitted infections amongst men who have sex with men (MSM) in South Africa

“You Are on the Right Track With the App:” Qualitative Analysis of Mobile Phone Use and User Feedback Regarding Mobile Phone Sexual Risk Assessments for HIV Prevention Research

Pre-exposure Prophylaxis Adherence Measured by Plasma Drug Level in MTN-001: Comparison Between Vaginal Gel and Oral Tablets in Two Geographic Regions

Contact Info

Product

Resources

About