Preparing for Serious Communicable Diseases in the United States: What the Ebola Virus Epidemic Has Taught Us

Varkey, Jay B.; Ribner, Bruce S.

doi:10.1128/9781555819453.ch2

Cited by 3 publications

(3 citation statements)

References 42 publications

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“…Since the 2014 Ebola epidemic, preparedness for communicable disease outbreaks in communities and hospitals has been emphasized [ [21] , [22] , [23] ]. In Korea, after the hospital transmissions of Middle East Respiratory Syndrome (MERS) in 2015 [ 24 , 25 ], the EMS Act was revised to improve the ED environment, which included installing ventilation systems, separating the entrance from the isolation area, expanding bed space, setting up isolation rooms with negative pressure in Level-1 EDs, and controlling access of ED visitors [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Impact of temporary closures of emergency departments during the COVID-19 outbreak on clinical outcomes for emergency patients in a metropolitan area

Lee

Ryoo

et al. 2021

The American Journal of Emergency Medicine

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Background During the early phase of the coronavirus disease 2019 (COVID-19) outbreak, many emergency departments (EDs) were exposed to COVID-19 and were temporarily closed according to national protocol of Korea. We aimed to evaluate the effect of concurrent and recurrent temporary closures of EDs on the clinical outcomes of patients who visited EDs during the COVID-19 outbreak. Methods This cross-sectional study used a nationwide emergency patient database. Patients who visited one of the 46 EDs in Daegu and Gyeongbuk between January 21 and April 14, 2020 were included. The main exposure variable was the first medical contact (ED visit or 119 call to emergency medical services (EMS)) during closure of at least one ED. There were 25 temporary closures of six Level-1 and Level-2 EDs between February 18 and March 17, 2020. We constructed a dataset by performing bidirectional crossover matching and conducted a conditional logistic regression analysis where the primary outcome was in-hospital mortality. Results Of the 94,360 eligible study participants, 36,327 were classified into the non-EMS-use group and 10,116 were classified into the EMS-use group. In-hospital mortality rates were 2.0% and 1.6% for the temporary-closure and no-closure groups in the non-EMS-use group ( p -value, 0.03) and 8.7% and 7.4% in the EMS-use group ( p -value, 0.02), respectively. In the conditional logistic analysis for in-hospital mortality, the odds ratios (95% confidence intervals) of the temporary-closure group compared the no-closure group were 1.22 (1.03–1.44) among the non-EMS-use group and 1.23 (1.04–1.46) among the EMS-use group. Conclusion The temporary closures of EDs due to the unpredicted COVID-19 exposure resulted in an increase in emergency patients' in-hospital mortality rates irrespective of whether they used EMS. Preparing regional EMS systems to cope with new outbreaks is essential to protect the safety of all citizens.

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Section: Discussionmentioning

confidence: 99%

Impact of temporary closures of emergency departments during the COVID-19 outbreak on clinical outcomes for emergency patients in a metropolitan area

Lee

Ryoo

et al. 2021

The American Journal of Emergency Medicine

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“…The ease with which stem cells can be isolated and the unique ability of stem cells to form any desired cell type renders them extremely important for understanding human physiology under normal as well as pathological conditions [1,2,3]. With the advent of 3D organoid systems, research has taken a safer Opinion Article and faster approach in understanding disease mechanisms and pathogenesis [4].…”

Section: Introductionmentioning

confidence: 99%

Stem Cell Modelling in COVID-19

Nagpal

Srivastav

Ekuta

2020

JAMMR

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The ability of stem cells to differentiate into any desired cell type can make them an indispensable tool in COVID-19 modelling studies. Stem cells derived from patients with preexisting conditions or derived from vulnerable populations such as children, can also assist scientists in understanding the unique contributions of these diverse factors to variations in COVID-19 infection responses. Innovative approaches are urgently needed to adequately address the global impact of COVID-19. Stem cell based strategies offer such an approach.

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“…] led to additional preparedness ventures in the US. 4 This included standing up the National Ebola Training and Education Center (NETEC), recently rebranded as the National Emerging Special Pathogen Training and Education Center, to assist with frontline and facility-level preparedness focused on pathogens like Ebola transmitted through body fluid exposure. 5 Conversely, some countries in Asia have had prior experience with respiratory pathogens through outbreaks of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome and have a robust response plan.…”

mentioning

confidence: 99%

Preparedness, Adaptation, and Innovation: Approach to the COVID-19 Pandemic at a Decentralized, Quaternary Care Department of Emergency Medicine

Yaffee

Peacock

Seitz

et al. 2020

WestJEM

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The COVID-19 pandemic has required healthcare systems to be creative and adaptable in response to an unprecedented crisis. Below we describe how we prepared for and adapted to this pandemic at our decentralized, quaternary-care department of emergency medicine, with specific recommendations from our experience. We discuss our longstanding history of institutional preparedness, as well as adaptations in triage, staffing, workflow, and communications. We also discuss innovation through working with industry on solutions in personal protective equipment, as well as telemedicine and methods for improving morale. These preparedness and response solutions and recommendations may be useful moving forward as we transition between response and recovery in this pandemic as well as future pandemics.

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Preparing for Serious Communicable Diseases in the United States: What the Ebola Virus Epidemic Has Taught Us

Cited by 3 publications

References 42 publications

Impact of temporary closures of emergency departments during the COVID-19 outbreak on clinical outcomes for emergency patients in a metropolitan area

Impact of temporary closures of emergency departments during the COVID-19 outbreak on clinical outcomes for emergency patients in a metropolitan area

Stem Cell Modelling in COVID-19

Preparedness, Adaptation, and Innovation: Approach to the COVID-19 Pandemic at a Decentralized, Quaternary Care Department of Emergency Medicine

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