Preparative synthesis of isoprene oxide

Odoriferous Cyclic Ethers via Co‐Halogenation Reaction: Facile Preparation of Nerol Oxide, Florol®, Florol® Methyl Ether, and Pityol® Methyl Ether

“…Florol is used as a diastereoisomeric pair of racemates, and its exact method of preparation has not been disclosed by the firm [13]. All the previously reported syntheses of 2 [14] are low-yielding and involve complex reaction procedures. In 2004, Abate et al [15] reported the first total synthesis of enantiomerically enriched Florol (2) by a biocatalytic route for the purpose of odor and threshold evaluations.…”

“…The org. layer was washed neutral with H 2 O (3 15 ml), dried (CaCl 2 ), and concentrated to give a pale-yellow oily substance, which, after CC (SiO 2 ), gave 10 (1.77 g, 88% (14).…”