Preparative separation of major xanthones from mangosteen pericarp using high‐performance centrifugal partition chromatography

Shan, Yichu; Zhang, Wei

doi:10.1002/jssc.200900774

Cited by 13 publications

(3 citation statements)

References 27 publications

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“…Polar aglycones as well as glycosides of xanthones are also resolved on reversed phase column (C 8 and C 18 ) using acetonitrile-water as mobile phase [75,76]. High-speed counter current chromatography (HSCCC) and high performance centrifugal partition chromatography (HPCPC) were also used for the separation and isolation of mangiferin and neomangiferin from an extract of Anemarrhena asphodeloides [77] and -mangostins andmangostins from mangosteen pericarp, respectively [78].…”

Section: Methods For Isolation and Characterization Of Xanthonesmentioning

confidence: 99%

Naturally Occurring Xanthones: Chemistry and Biology

Negi

Bisht

Singh

et al. 2013

Journal of Applied Chemistry

161

120

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Xanthones are one of the biggest classes of compounds in natural product chemistry. A number of xanthones have been isolated from natural sources of higher plants, fungi, ferns, and lichens. They have gradually risen to great importance because of their medicinal properties. This review focuses on the types, isolation, characterization, biological applications, and biosynthesis of naturally occurring xanthones isolated so far. Different physicochemical and instrumental methods such as liquid-solid and liquid-liquid extraction, TLC, flash chromatography, column chromatography, IR,1H NMR and13C NMR spectroscopy, GLC, HPLC, GC, and LCMS have been widely used for isolation and structural elucidation of xanthones. Hepatoprotective, anticarcinogenic, antileprosy, antimalarial, antioxidant, anticholinergic, mutagenicity, radioprotective, immunomodulatory, antibone resorption, antiparasitic, neuraminidase inhibitory, anticomplement, antibacterial, antifungal, algicidal, anti-HIV, cardioprotective, antitumoral, antidiabetes, antihyperlipidemic, antiatherogenic, anti-inflammatory, antiulcer, antidiabetic, hypolipidemic, analgesic, antiasthmatic, antihistaminic, antiamoebic, diuretic, antidiarrheal, larvicidal, and ovicidal activities have been reported for natural occurring xanthones. To a certain extent, this review provides necessary foundation for further research and development of new medicines.

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Section: Methods For Isolation and Characterization Of Xanthonesmentioning

confidence: 99%

Naturally Occurring Xanthones: Chemistry and Biology

Negi

Bisht

Singh

et al. 2013

Journal of Applied Chemistry

161

120

View full text Add to dashboard Cite

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“…e anti-inflammatory property of G.mangostana has been exploited for the treatments of eczema and psoriasis [4][5][6]. Phytochemical studies of G.mangostana have identified xanthones as the major constituents, particularly α-mangostin [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Alpha-Mangostin Activates MOAP-1 Tumor Suppressor and Mitochondrial Signaling in MCF-7 Human Breast Cancer Cells

Simon

Lim

Jayakumar

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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α-Mangostin, one of the major constituents of Garcinia mangostana, has been reported to possess several biological activities, including antioxidant, anti-inflammatory, antibacterial, and cytotoxic activities associated with the inhibition of cell proliferation and activation of apoptosis. However, the cellular signaling pathway mediated by α-mangostin has not been firmly established. To investigate the cellular activities of α-mangostin, human cancer cells, MCF-7 and MCF-7-CR cells, were treated with α-mangostin to measure the cellular responses, including cytotoxicity, protein-protein interaction, and protein expression. Cancer cells stably expressed Myc-BCL-XL and HA-MOAP-1 were also included in the studies to delineate the cell signaling events mediated by α-mangostin. Our results showed that the apoptosis signaling mediated by α-mangostin involves the upregulation of endogenous MOAP-1, which interacts with α-mangostin activated BAX (act-BAX) while downregulating the expression of BCL-XL. Moreover, α-mangostin was found to induce BAX oligomerization, the release of mitochondrial cytochrome C, and activation of caspase in MCF-7 cells. In overexpression studies, MCF-7 cells and spheroids stably expressed HA-MOAP-1 and Myc-BCL-XL exhibited differential chemosensitivity toward α-mangostin in which the stable clones expressing HA-MOAP-1 and MYC-BCL-XL were chemosensitive and chemoresistant to the apoptosis signaling events mediated by α-mangostin, respectively, when compared to untreated cells. Together, the data suggest that the cytotoxicity of α-mangostin involves the activation of MOAP-1 tumor suppressor and its interaction with act-BAX, leading to mitochondria dysfunction and cell death.

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“…Mangosteen (Garcinia mangostana L.) belongs to the Clusiaceae family. The pericarp of the fruit is particularly known to contain secondary metabolites such as xanthone (Shan and Zhang 2010), anthocyanins (Zarena and Udaya Sankar 2012), proanthocyanidins (Fu et al 2007) and phenolic acids (Zadernowski et al 2009). These metabolites contribute to the anti-inflammatory, anti-bacterial, anti-tumor and anti-oxidative properties reported (Pedraza-Chaverri et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Metabolite profiles of callus and cell suspension cultures of mangosteen

et al. 2018

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Callus was induced from mangosteen ( L.) young purple-red leaves on Murashige and Skoog basal medium with various combinations of plant growth regulators. Murashige and Skoog medium with 4.44 µM 6-benzylaminopurine and 4.52 µM 2,4-dichlorophenoxyacetic acid was the best for friable callus induction. This friable callus was used for the initiation of cell suspension culture. The effects of different combinations of 6-benzylaminopurine and 2,4-dichlorophenoxyacetic acid, carbon sources and inoculum sizes were tested. It was found that combination of 2.22 µM 6-benzylaminopurine + 2.26 µM 2,4-dichlorophenoxyacetic acid, glucose (30 g/l) and 1.5 g/50 ml inoculum size was the best for cell growth. Callus and cell suspension cultures were then treated either with 100 µM methyl jasmonate as an elicitor for 5 days, or 0.5 g/l casein hydrolysate as an organic supplement for 7 days. Metabolites were then extracted and profiled using liquid chromatography-time of flight mass spectrometry. Multivariate discriminant analyses revealed significant metabolite differences ( ≤ 0.05) for callus and suspension cells treated either with methyl jasmonate or casein hydrolysate. Based on MS/MS data, methyl jasmonate stimulated the production of an alkaloid (thalsimine) and fatty acid (phosphatidyl ethanolamine) in suspension cells while in callus, an alkaloid (thiacremonone) and glucosinolate (7-methylthioheptanaldoxime) was produced. Meanwhile casein hydrolysate stimulated the production of alkaloids such as 3ß,6ß-dihydroxynortropane and cis-hinokiresinol and triterpenoids such as schidigerasaponin and talinumoside in suspension cells. This study provides evidence on the potential of secondary metabolite production from in vitro culture of mangosteen.

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Preparative separation of major xanthones from mangosteen pericarp using high‐performance centrifugal partition chromatography

Cited by 13 publications

References 27 publications

Naturally Occurring Xanthones: Chemistry and Biology

Naturally Occurring Xanthones: Chemistry and Biology

Alpha-Mangostin Activates MOAP-1 Tumor Suppressor and Mitochondrial Signaling in MCF-7 Human Breast Cancer Cells

Metabolite profiles of callus and cell suspension cultures of mangosteen

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