Preparative Isolation, Fast Centrifugal Partition Chromatography Purification and Biological Activity of Cajaflavanone from <i>Derris ferruginea</i> Stems

Morel, Sylvie; Landreau, Anne; Nguyễn, Văn Hùng; Derbré, Séverine; Grellier, Philippe; Pape, Patrice Le; Pagniez, Fabrice; Litaudon, Marc; Richomme, Pascal

doi:10.1002/pca.1336

Cited by 16 publications

(15 citation statements)

References 41 publications

(49 reference statements)

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“…Moreover, we found that fruit juice and leafy stem extracts of Momordica charantia exhibited good quantity of total flavonoid, confirming the observed antioxidant activity of both extracts revealed by this study. The tannins act as scavengers of free radicals which are produced during lipid oxidation [ 45 ]. It has been observed that many flavonoids and tannins exhibit antioxidant activities, detoxification, and numerous health promoter effects such as anti-inflammatory and anti-diabetic effects [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

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Evidence of Immunosuppressive and Th2 Immune Polarizing Effects of Antidiabetic Momordica charantia Fruit Juice

Fachinan

Fagninou

Nekoua

et al. 2017

BioMed Research International

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The mechanism of action of the antidiabetic capacity of Momordica charantia is still under investigation. Here, we assessed phytochemical compositions, antioxidant activity, and effects of total and filtered fruit and leafy stem juices of Momordica charantia on human T cell proliferation and differentiation through quantification of Th1/Th2 cytokines. In the absence of stimulation, total fruit and leafy stem juices induced significant T cell proliferation. Under PHA stimulation, both juices potentiated plant-induced T cell proliferation. However, the filtered fruit and leafy stem juices significantly inhibited PHA-stimulated T cell proliferation, while neither juice influenced T cell proliferation. Moreover, total and filtered fruit juice increased IL-4 secretion, while total and filtered leafy stem juice enhanced IFN-γ production. Phytochemical screening revealed the presence of tannins, flavonoids, anthocyans, steroids, and triterpenoids in both juices. Alkaloids, quinone derivatives, cardenolides, and cyanogenic derivatives were undetectable. The saponins present in total juices were undetectable after filtration. Moreover, both juices had appreciable antioxidant capacity. Our study supports the type 1 antidiabetic effect of filtered fruit juice of M. charantia which may be related to its immunosuppressive and T-helper 2 cell inducing capacities. Due to their immune-stimulatory activities and their ability to increase T-helper 1 cell cytokines, total fruit and leafy stem juices may serve in the treatment of immunodeficiency and certain infections.

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Section: Discussionmentioning

confidence: 99%

“…The tannins act as scavengers of free radicals which are produced during lipid oxidation [ 45 ]. It has been observed that many flavonoids and tannins exhibit antioxidant activities, detoxification, and numerous health promoter effects such as anti-inflammatory and anti-diabetic effects [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Evidence of Immunosuppressive and Th2 Immune Polarizing Effects of Antidiabetic Momordica charantia Fruit Juice

Fachinan

Fagninou

Nekoua

et al. 2017

BioMed Research International

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“…Emerging evidence has shown that prenylated flavonoids could protect plants against diseases by strongly inhibiting bacterial and fungal activities (Inui et al, 2012;Morel et al, 2012;Mukne et al, 2011;Ruddock et al, 2011;Sasaki et al, 2012;Shen et al, 2012;Sun et al, 2012;Sutthivaiyakit et al, 2009). There was some evidence suggesting that prenylation increased the lipophilicity of flavonoids, which resulted in an increased affinity to biological membranes and an improved interaction with target proteins (Hatano et al, 2000).…”

Section: Antibacterial Activitymentioning

confidence: 99%

A systematic review on biological activities of prenylated flavonoids

Chen

Mukwaya

Wong

et al. 2013

Pharmaceutical Biology

185

136

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Context: Prenylated flavonoids are a unique class of naturally occurring flavonoids that exist especially for the plant's self-defensive strategy. This special class of flavonoids increases the bioactivities of their backbone flavonoids with non-prenylation; therefore, prenylated flavonoids have more potential to be developed and utilized. Objective: The number, position and type of the prenyl group on the flavonoids backbone structure may have close relationships with the bioactivities of flavonoids. Methods: PubMed and WEB OF KNOWLEDGEÕ were used to search articles published in English between 1 January 2002 and 31 December 2012, which discuss the structure-activity relationship between prenylated flavonoids and their bioactivities. Results: It is proposed that the prenyl-moiety makes the backbone compound more lipophilic, which leads to its high affinity with cell membranes. The prenylation brings the flavonoids with enhancement of antibacterial, anti-inflammatory, antioxidant, cytotoxicity, larvicidal as well as estrogenic activities. However, it is reported that the prenyl-moiety decreases the bioavailability and plasma absorption of prenylated flavonoids. Conclusion: The prenyl group affects the bioactivities of flavonoids in certain ways, while the action mechanisms and the structure-activity relationship as well as more in vivo studies even clinical validation trials need to be further investigated.

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“…S1 in the Supplementary material). Due to the shear forces between both phases, the mobile phase is dispersed in the stationary phase and thus, biochemical products using CPC have been reported in the last years [8][9][10][11][12][13]. Thereby, aqueous two-phase systems (ATPS) were preferred as systems.…”

Section: Introductionmentioning

confidence: 99%

Separation of active laccases from Pleurotus sapidus culture supernatant using aqueous two-phase systems in centrifugal partition chromatography

Schwienheer

Zeiner

Merz

2015

Journal of Chromatography B

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Preparative Isolation, Fast Centrifugal Partition Chromatography Purification and Biological Activity of Cajaflavanone from Derris ferruginea Stems

Abstract: A simple and efficient procedure, in comparison with other preparative methods, for bioactive cajaflavone purification has been developed using FCPC.

Cited by 16 publications

References 41 publications

Evidence of Immunosuppressive and Th2 Immune Polarizing Effects of Antidiabetic Momordica charantia Fruit Juice

Evidence of Immunosuppressive and Th2 Immune Polarizing Effects of Antidiabetic Momordica charantia Fruit Juice

A systematic review on biological activities of prenylated flavonoids

Separation of active laccases from Pleurotus sapidus culture supernatant using aqueous two-phase systems in centrifugal partition chromatography

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