Preparative Gas Chromatography as a Sample Preparation Approach

Evolution and status of preparative gas chromatography as a green sample-preparation technique

“…In this matter, the wide-bore column with a thick stationary phase film is the best compromise between the amount injected and the separation capability. MD chromatography, especially in heart-cut mode, coupling two or more columns equipped with different stationary phases, has also demonstrated its suitability for enhancing the peak capacity in prep-GC applications [18]. In recent years, authors exploited different columns for coupling {e.g., apolar-polyethylene glycol [26], apolar-50% diphenyl [29], and apolar-polyethylene glycol-medium polarity IL [31,35,36]}.…”

“…Since 2010, reviews, mainly based on packed columns [15] or generally on natural-product isolation [16], books [17][18][19] and applications of prep-GC in different fields have been reported using capillary columns [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37], directly connected to a preparative station or exploiting a heart-cut step with a Deans switch (DS) device at the end of the GC column to allow switching between detector and sample collector [19,27,28,31,[35][36][37]. Furthermore, at least four patents were published in PCGC [38][39][40][41].…”