Preparation, X-ray crystal structure, and 195Pt NMR spectra of platinum(II) with dipeptides and dipeptide methyl esters

Preparation of platinum(IV) complexes with dipeptide and diimine. X-ray crystal structure and 195Pt NMR spectra

“…Dhara reported the preparation of cis-[PtCl 2 (NH 3 ) 2 ] in good yield using K 2 [PtCl 4 ] and KI [10]. By adding KI to K 2 PtCl 4 or H 2 PtCl 6 aqueous solution in the first step and AgNO 3 in the last step, the reaction of platinum ion with peptides was completed within a short time to obtain analytically pure yellow products in the form of K[PtCl 2 (dipeptideOCH 3 [11][12][13]. In the majority of derivatives synthesized, the major structural features of the prototype drug are usually retained, following the Cleare-Hoeschele structure-activity relationships [14], and that recommend that the complexes be neutral.…”

Platinum(IV) Complexes with Dipeptide. X-ray Crystal Structure, 195Pt NMR Spectra, and Their Inhibitory Glucose Metabolism Activity in Candida albicans

“…7 Recently, we reported the preparation of the platinum(II) complexes with dipeptides containing β-alanine or amino acid methyl esters. 9 The addition of an aqueous solution containing the dipeptide of β-alanine to a solution of K 2 PtCl 4 has produced several species. As the pH of the solution decreased, it was kept at ca.…”

“…[PtC1 6 ] 2- as the starting material is described to be unsuitable due to its kinetic inertness and/or a partial reduction to give platinum(II) . Recently, we reported the preparation of the platinum(II) complexes with dipeptides containing β-alanine or amino acid methyl esters . The addition of an aqueous solution containing the dipeptide of β-alanine to a solution of K 2 PtCl 4 has produced several species.…”