Preparation, swelling characteristics and evaluation of hydrogels for stomach specific drug delivery

Ravichandran, Praveen Kumar; Shantha, K. L.; Rao, K. Panduranga

doi:10.1016/s0378-5173(97)00131-2

Cited by 44 publications

(18 citation statements)

References 9 publications

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“…The chemical and physical properties of the polymers are significantly different from those of the monomers. The polymers developed from these monomers have been reported as non-toxic and have been used to develop the drug delivery systems [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Radiation crosslinked polymerization of methacrylamide and psyllium to develop antibiotic drug delivery device

Singh

Sharma

Kumar

et al. 2009

International Journal of Biological Macromolecules

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Section: Introductionmentioning

confidence: 99%

Radiation crosslinked polymerization of methacrylamide and psyllium to develop antibiotic drug delivery device

Singh

Sharma

Kumar

et al. 2009

International Journal of Biological Macromolecules

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“…1 In particular, pH sensitive drug release is desirable for applications such as insulin delivery [2][3][4] and selective drug delivery to the stomach 5,6 or intestine. 7 Changes in pH are also known to coincide with the healing response 8 and the growth of cancerous tumors.…”

Section: Introductionmentioning

confidence: 99%

Poly(D, L‐lactide‐co‐glycolide)/poly(ethylenimine) blend matrix system for pH sensitive drug delivery

Sutton

Durand

Shuai

et al. 2006

J of Applied Polymer Sci

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Poly(d,l-lactide-co-glycolide) (PLGA) and poly(ethylenimine) (PEI) were blended and found to form a homogeneous pH sensitive matrix for drug release. Differential scanning calorimetry (DSC) studies of the PLGA/PEI blends showed a single glass transition temperature at all compositions. Fourier transform infrared spectroscopy (FTIR) demonstrated that the PLGA carbonyl peak at 1760 cm Ϫ1 shifted to 1666 cm Ϫ1 as a result of amide bond formation between the two polymers. This was confirmed by 13 C nuclear magnetic resonance studies. A PLGA/PEI matrix of 90/10 weight ratio was chosen for evaluation for controlled drug release. Both hydrophobic ␤-lapachone and hydrophilic rhodamine B showed pH dependent release profiles with faster release kinetics at lower pH values. The observed pH sensitive drug release was mainly attributed to two factors, pH dependent swelling and protonation of the PEI-PLGA matrix. These results demonstrate utility of a PLGA/ PEI matrix and its potential application in pH responsive drug delivery.

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“…In particular, pH-sensitive hydrogels that undergo swelling changes in response to pH of the surrounding medium have become increasingly important because of their potential applications in the development of targeted drug delivery systems. 14,15 This not only improves therapeutic efficiency but also reduces or eliminates side effects of oral controlled drugs by reasonably delivering drugs to specific regions of the gastrointestinal (GI) tract. Among various methods of targeting the specific regions, the strategy utilizing pH changes within the GI tract 16 is of current interest in controlled drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Ionizable interpenetrating polymer networks of carboxymethyl cellulose and polyacrylic acid: Evaluation of water uptake

Bajpai¹,

Mishra²

2004

J of Applied Polymer Sci

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A semi interpenetrating polymer network (IPN) of carboxymethyl cellulose (CMC) and crosslinked polyacrylic acid (PAA) has been prepared and its watersorption capacity has been evaluated as a function of chemical architecture of the IPN, pH, and temperature of the swelling medium. The water uptake potential of the IPNs has also been investigated in inorganic salt containing aqueous solutions and simulated biological fluids. The IPN was characterized by IR spectral analysis, and the network parameters such as average molecular weight between crosslinks (M c ), crosslink density (q), and number of elastically effective chains (V e ) have been evaluated by watersorption measurements.

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Preparation, swelling characteristics and evaluation of hydrogels for stomach specific drug delivery

Cited by 44 publications

References 9 publications

Radiation crosslinked polymerization of methacrylamide and psyllium to develop antibiotic drug delivery device

Radiation crosslinked polymerization of methacrylamide and psyllium to develop antibiotic drug delivery device

Poly(D, L‐lactide‐co‐glycolide)/poly(ethylenimine) blend matrix system for pH sensitive drug delivery

Ionizable interpenetrating polymer networks of carboxymethyl cellulose and polyacrylic acid: Evaluation of water uptake

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