Preparation, structural characterization and bioactivities of Se-containing polysaccharide: A review

Cheng, Lizeng; Wang, Yuanfeng; He, Xiao-Yan; Wei, Xinlin

doi:10.1016/j.ijbiomac.2018.07.106

Cited by 72 publications

(26 citation statements)

References 98 publications

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“…In addition to the selenylation method used, the selenium content of selenylated polysaccharides (10 2 -10 4 µg/g) [281] also depends on the structure and chemical character of the native polysaccharide. For example, using the same selenylation method, the ability to incorporate selenium into lily polysaccharides (11,770-39,780 µg/g) [267] was 26-88-fold higher than that of Murus alba polysaccharides (452 µg/g) [275].…”

Section: Se-esters-selenites and Diselenites Of Polysaccharidesmentioning

confidence: 99%

“…The most commonly used method to obtain the selenite-polysaccharide is the chemical reaction with nitric acid and sodium selenite [281]. The general procedure includes the following steps [281]: native polysaccharides are dissolved in nitric acid and react with sodium selenite in the presence of BaCl 2 . Then, the solution is neutralized with NaOH, and Ba 2+ ions are removed by precipitation.…”

Section: Chemical Modification Of Natural Polysaccharidesmentioning

confidence: 99%

“…These selenated polysaccharides can thus serve not only as a new source of selenium, but also as compounds with a new, higher bioactivity. Se-polysaccharides show a higher immunomodulating, anticancer, antioxidant, and hepatoprotective bioactivity in relation to the native polysaccharides [10,281] due to the synergistic effect of selenium and polysaccharides (despite their different mechanisms of action) [11,39]. In general, along with the increase in selenium content, the bioactivity of the modified polysaccharide also increases, but this relation is still a subject of research.…”

Section: Biological Activity Of Se-polysaccharidesmentioning

confidence: 99%

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Selenium-Containing Polysaccharides—Structural Diversity, Biosynthesis, Chemical Modifications and Biological Activity

2021

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Selenosugars are a group of sugar derivatives of great structural diversity (e.g., molar masses, selenium oxidation state, and selenium binding), obtained as a result of biosynthesis, chemical modification of natural compounds, or chemical synthesis. Seleno-monosaccharides and disaccharides are known to be non-toxic products of the natural metabolism of selenium compounds in mammals. In the case of the selenium-containing polysaccharides of natural origin, their formation is also postulated as a form of detoxification of excess selenium in microorganisms, mushroom, and plants. The valency of selenium in selenium-containing polysaccharides can be: 0 (encapsulated nano-selenium), IV (selenites of polysaccharides), or II (selenoglycosides or selenium built into the sugar ring to replace oxygen). The great interest in Se-polysaccharides results from the expected synergy between selenium and polysaccharides. Several plant- and mushroom-derived polysaccharides are potent macromolecules with antitumor, immunomodulatory, antioxidant, and other biological properties. Selenium, a trace element of fundamental importance to human health, has been shown to possess several analogous functions. The mechanism by which selenium exerts anticancer and immunomodulatory activity differs from that of polysaccharide fractions, but a similar pharmacological effect suggests a possible synergy of these two agents. Various functions of Se-polysaccharides have been explored, including antitumor, immune-enhancement, antioxidant, antidiabetic, anti-inflammatory, hepatoprotective, and neuroprotective activities. Due to being non-toxic or much less toxic than inorganic selenium compounds, Se-polysaccharides are potential dietary supplements that could be used, e.g., in chemoprevention.

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Section: Se-esters-selenites and Diselenites Of Polysaccharidesmentioning

confidence: 99%

Section: Chemical Modification Of Natural Polysaccharidesmentioning

confidence: 99%

Section: Biological Activity Of Se-polysaccharidesmentioning

confidence: 99%

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Selenium-Containing Polysaccharides—Structural Diversity, Biosynthesis, Chemical Modifications and Biological Activity

2021

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“…Se compounds can be classified into two groups based on Se speciation, namely organic Se compounds (selenoamino acid, selenoprotein, Se-containing polysaccharide) and inorganic Se compounds (selenite, selenate). Compared with inorganic Se compounds, organic Se compounds have the advantages of higher bioavailability and lower toxicity ( Cheng, Wang, He, & Wei, 2018 ). Cheng et al (2018) reviewed the preparation, structure and physiological functions of Se-containing polysaccharide such as antioxidant, antitumor, immune-enhancement, hepatoprotective, antidiabetic, anti-inflammatory, and neuroprotective activities.…”

Section: Molar Mass Effects In the Stabilisation Of Suspensions And Ementioning

confidence: 99%

“…Compared with inorganic Se compounds, organic Se compounds have the advantages of higher bioavailability and lower toxicity ( Cheng, Wang, He, & Wei, 2018 ). Cheng et al (2018) reviewed the preparation, structure and physiological functions of Se-containing polysaccharide such as antioxidant, antitumor, immune-enhancement, hepatoprotective, antidiabetic, anti-inflammatory, and neuroprotective activities. They concluded that natural Se-containing polysaccharide is Se-conjugated macromolecule, with Se content and molecular weight generally ranged from 0 to 50 μg/g and 10 3 –10 6 Da, respectively.…”

Section: Molar Mass Effects In the Stabilisation Of Suspensions And Ementioning

confidence: 99%

Molar mass effect in food and health

Nishinari

Fang

2021

Food Hydrocolloids

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It is demanded to supply foods with good quality for all the humans. With the advent of aging society, palatable and healthy foods are required to improve the quality of life and reduce the burden of finance for medical expenditure. Food hydrocolloids can contribute to this demand by versatile functions such as thickening, gelling, stabilising, and emulsifying, controlling texture and flavour release in food processing. Molar mass effects on viscosity and diffusion in liquid foods, and on mechanical and other physical properties of solid and semi-solid foods and films are overviewed. In these functions, the molar mass is one of the key factors, and therefore, the effects of molar mass on various health problems related to noncommunicable diseases or symptoms such as cancer, hyperlipidemia, hyperglycemia, constipation, high blood pressure, knee pain, osteoporosis, cystic fibrosis and dysphagia are described. Understanding these problems only from the viewpoint of molar mass is limited since other structural characteristics, conformation, branching, blockiness in copolymers such as pectin and alginate, degree of substitution as well as the position of the substituents are sometimes the determining factor rather than the molar mass. Nevertheless, comparison of different behaviours and functions in different polymers from the viewpoint of molar mass is expected to be useful to find a common characteristics, which may be helpful to understand the mechanism in other problems.

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Selenylation of Guar Gum Mediated by N‐Methyl‐2‐pyrrolidone Hydrosulfate: Insights into Regulation of Selenium Content and Molecular Weight

Zhou

et al. 2022

ChemistrySelect

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Selenylation is an important modification strategy of polysaccharide, however, one of the main obstacles is that the weak esterification ability of selenide reagent, which leads to the low Se conversion efficiency during reaction. Here, we used N-methyl-2-pyrrolidone hydrosulfate ([HNMP]HSO 4 ) as acid catalyst efficiently synthesized selenized guar gum (Se-GGs) to improve the activity of selenide reagent. The chemical structure of GG and selenized derivatives was investigated using FT-IR, 1D/2D NMR spectrometry and atomic force microscopy (AFM).The results indicated that selenite groups existed in Se-GGs and the substitution position was at C6. Furthermore, it was also demonstrated that [HNMP]HSO 4 had a dual influence on GG by increasing the Se content (from 181.3 to 9072.8 μg/g) and regulating the molecular weight, which was due to strong Brönsted acidic proton (H + ). These results illustrated a new synthetic method for preparing functional polysaccharides with a broad range of potential applications.

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Preparation, structural characterization and bioactivities of Se-containing polysaccharide: A review

Cited by 72 publications

References 98 publications

Selenium-Containing Polysaccharides—Structural Diversity, Biosynthesis, Chemical Modifications and Biological Activity

Selenium-Containing Polysaccharides—Structural Diversity, Biosynthesis, Chemical Modifications and Biological Activity

Molar mass effect in food and health

Selenylation of Guar Gum Mediated by N‐Methyl‐2‐pyrrolidone Hydrosulfate: Insights into Regulation of Selenium Content and Molecular Weight

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