Preparation, structural characterisation and release study of novel hybrid microspheres entrapping nanoselenium, produced by green synthesis

Abstract

The main goal of this study was to synthesise and characterise different formulations based on alginate and alginate/chitosan microspheres containing nanoselenium (nano-Se) for controlled delivery applications. Nanosize elemental selenium was produced by using probiotic yogurt bacteria () in a fermentation procedure. The structural and morphological characterisation of the microspheres was performed by Fourier transform infrared (FTIR), X-ray diffraction (XRD) and scanning electron microscopy (SEM) analysis. FTIR and XRD pattern indicated that was an effective cross-linking of selenium nanoparticles within the polymeric matrix in both cases. The SEM images reveal that selenium nanoparticles are mainly exposed on the surface of alginate, in contrast to porous structure of alginate/chitosan/nano-Se, interconnected in a regular network. This architecture type has a considerable importance in the delivery process, as demonstrated by differential pulse voltammetry. Selenium release from both matrices is pH sensitive. Moreover, chitosan blended with alginate minimise the release of encapsulated selenium, in simulated gastric fluid, and prolong the duration of release in intestinal fluid. The overall effect is the enhancement of total percentage release concomitant with the longer duration of action. The authors' formulation based on alginate/chitosan is a convenient matrix to be used for selenium delivery in duodenum, caecum and colon.

Eco-friendly, Facile and Rapid Way for Synthesis of Selenium Nanoparticles Production, structural and morphological characterisation

“…5b) which suggests that the nanoparticles are not crystalline. Some previous studies related to crystalline phase investigation of selenium nanoparticles suggested that stable amorphous forms (or even low crystallinity) are advantageous for biological applications, as they exhibit better solubility and [32,33].We consider that this method is suitable for different biological applications such drug release, functional food or nutritional supplements, being not only facile and rapid, but also very safe for the environment and low cost.…”

Selenium-Containing Polysaccharides—Structural Diversity, Biosynthesis, Chemical Modifications and Biological Activity

“…Several types of bacteria and cyanobacteria cultivated in submerged cultures have already been used for the biosynthesis of SeNPs, and these include Escherichia coli [366], Enterobacter cloacae [367], Pseudomonas aeruginosa [368], Klebsiella pneumoniae [369], Zooglea ramigera [370], Lactobacillus casei [371], Streptomyces sp. [372], Arthrospira [Spirulina] platensis [373], and many others.…”

Advances in green synthesis of selenium nanoparticles and their application in food packaging

“…Selenium is an essential trace mineral in humans that is involved in the maintenance of health and growth (Cavalu et al ., 2017; Qiu et al ., 2018; Nastulyavichus et al ., 2019). It has various physiological roles in humans such as acting as antioxidant, preventing the formation of tumours and immune regulation (Yan et al ., 2018; Tang et al ., 2019).…”