Preparation, property of the complex of carboxymethyl chitosan grafted copolymer with iodine and application of it in cervical antibacterial biomembrane

Chen, Yu; Yang, Yi-Yan; Liao, Qingping; Wei, Yang; Ma, Wanfeng; Zhao, Jian; Zheng, Xionggao; Yang, Yang; Chen, Rui

doi:10.1016/j.msec.2016.05.027

Cited by 22 publications

(14 citation statements)

References 37 publications

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“…In this case, a greater variety of monomers have been grafted to chitosan via the grafted from procedure, for example, acrylic monomers [95,96,97,98,99,100,101,102,103,104,105,106,107,108,109,110,111,112,113], styrene [105], oligoethylene glycol methacrylate [114], N -vinyl-2-pyrrolidone [115,116], ε-caprolactone [36,37,116,117,118], lactide [119], urethane [120], indole [87], and aniline [121], among others. The types of polymerization and initiator to be employed depend on the selected monomer.…”

Section: Graft Copolymerizationmentioning

confidence: 99%

Chitosan Derivatives: Introducing New Functionalities with a Controlled Molecular Architecture for Innovative Materials

et al. 2018

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The functionalization of polymeric substances is of great interest for the development of innovative materials for advanced applications. For many decades, the functionalization of chitosan has been a convenient way to improve its properties with the aim of preparing new materials with specialized characteristics. In the present review, we summarize the latest methods for the modification and derivatization of chitin and chitosan under experimental conditions, which allow a control over the macromolecular architecture. This is because an understanding of the interdependence between chemical structure and properties is an important condition for proposing innovative materials. New advances in methods and strategies of functionalization such as the click chemistry approach, grafting onto copolymerization, coupling with cyclodextrins, and reactions in ionic liquids are discussed.

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Section: Graft Copolymerizationmentioning

confidence: 99%

Chitosan Derivatives: Introducing New Functionalities with a Controlled Molecular Architecture for Innovative Materials

et al. 2018

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“…An increase in pH leads to dissociation of COOH groups in lecithin, breakage of hydrogen bonds, and electrostatic repulsion of negatively charged carboxyl groups, thus allowing faster release of iodine from a composite film. An iodine complex with sodium acrylate and N-vinylpyrrolidone copolymers combined with carboxymethyl chitosan was used to prevent postsurgical infection after treating vaginal disorders [90]. Results from clinical studies showed that the composition in question is more effective than the standard treatment method.…”

Section: Applications Of Polymeric Iodophorsmentioning

confidence: 99%

“…An iodine complex with sodium acrylate and N -vinylpyrrolidone copolymers combined with carboxymethyl chitosan was used to prevent postsurgical infection after treating vaginal disorders [ 90 ]. Results from clinical studies showed that the composition in question is more effective than the standard treatment method.…”

Section: Applications Of Polymeric Iodophorsmentioning

confidence: 99%

Polymeric Iodophors: Preparation, Properties, and Biomedical Applications

2020

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The review summarizes the data on the main chemical and physiological properties of iodine and its capability of complexation with natural and synthetic polymers. Iodine is the best known antiseptic used to prevent and treat microbial infections. Its unique capability of complexation with certain polymers opens wide opportunities for targeted and prolonged delivery to target organs. Polymeric complexes with iodine have another color, other morphology, a higher electrical conductivity, and higher biological activity as compared with initial polymers. The formation of and ions is associated with iodine–polymer complexation. Iodine-containing biocompatible adhesive controlled-release formulations are designed as part of research into iodine–polymer complexes. The field is promising in terms of treating certain diseases because tolerance to iodine compounds does not usually develop in microbial cells.

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“…Various biocompatible polymers are used to enhance the binding of molecular iodine. They form strong complexes that can be used in medicine (9,10).…”

Section: Introductionmentioning

confidence: 99%

Subchronic Toxicity of the New Iodine Complex in Dogs and Rats

Islamov¹,

Кустова²,

Nersesyan

et al. 2020

Front. Vet. Sci.

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Background: Complexes of iodine (povidone-iodine and cadexomers) are among the most important antiseptics used in clinical and veterinary medicines. However, high local irritation activity and systemic toxicity limits their oral administration. The purpose of the study was to compare the effect of a new complex of iodine (PA, potentiator of anticancer antibiotics), in which iodine is coordinated by carbohydrates and polypeptides) on the organisms of rats and dogs treated orally with the drug for 30 days. Methods: Wistar rats and Beagle dogs served as experimental animal models. Effect of PA on the animal organism was examined through the measurements of hormones level changes, hematological and clinical chemistry parameters alterations, necropsy and histological examination. Results: The established maximum tolerated dose (MTD) of 2,000 mg/kg PA led to a decrease in the rate of body weight gain in male and female rats. Changes in hematological and certain biochemical parameters in rats at doses of 1,000 and 2,000 mg/kg were observed. Histological study of the thyroid gland revealed changes in the shape and size of the follicles along with colloid resorption. Administration of a half of MTD (180 mg/kg) and lower doses did not result in any change in dogs (thyroid-stimulating hormone, triiodothyronine, and thyroxine). Conclusions: The results of our study show that the pathogenetic action of PA takes place along the path of induction of an inflammatory response with the development of thyrotoxicosis, rather than hypothyroidism. The mechanism of induction of an inflammatory response is also confirmed by histological studies of lesions of the thyroid gland and testes in rats (Figure S1). The no-observed-adverse-effect level (NOAEL) of PA is estimated to be 180 mg/kg (or iodine 22.8 mg/kg) in dogs, which is equivalent to 100 mg/kg (or iodine 12.3 mg/kg) in humans.

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Preparation, property of the complex of carboxymethyl chitosan grafted copolymer with iodine and application of it in cervical antibacterial biomembrane

Cited by 22 publications

References 37 publications

Chitosan Derivatives: Introducing New Functionalities with a Controlled Molecular Architecture for Innovative Materials

Chitosan Derivatives: Introducing New Functionalities with a Controlled Molecular Architecture for Innovative Materials

Polymeric Iodophors: Preparation, Properties, and Biomedical Applications

Subchronic Toxicity of the New Iodine Complex in Dogs and Rats

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