Preparation, properties and cytotoxicity evaluation of a biodegradable polyester elastomer composite

Liu, Quanyong; Wu, Junyue; Tan, Tianwei; Zhang, Liqun; Chen, Dafu; Tian, Wei

doi:10.1016/j.polymdegradstab.2009.05.023

Cited by 62 publications

(46 citation statements)

References 53 publications

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“…The optical density value in the MTT assay reflected the number of the viable cells in culture medium. A larger optical density value compared with the negative control indicated the higher viability of the cells in the culture medium, that was to say, the cytotoxicity of the test sample is much lower or did not exist (Liu et al, 2009).…”

Section: Decellularization and Crosslinking Of The Tissuesmentioning

confidence: 99%

In vitro cytocompatibility evaluation of alginate dialdehyde for biological tissue fixation

Li²,

Wang

et al. 2013

Carbohydrate Polymers

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Section: Decellularization and Crosslinking Of The Tissuesmentioning

confidence: 99%

In vitro cytocompatibility evaluation of alginate dialdehyde for biological tissue fixation

Li²,

Wang

et al. 2013

Carbohydrate Polymers

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“…Previous studies have investigated approaches to create PPS composites based on the introduction of inorganic components such as halloysite nanotubes (clays) or multi-walled carbon nanotubes (MWCNTs) with improved mechanical properties. 70,72,73 However, the main drawback derived from the use of these inorganic nanoparticles in vivo is their potential toxicity as well as the uncertain (or non-existent) mechanism of removal from the body. 74 By using organic based llers these drawbacks could be lessen.…”

Section: 71mentioning

confidence: 99%

Mechanical properties and degradation studies of poly(mannitol sebacate)/cellulose nanocrystals nanocomposites

et al. 2015

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A., 2008, 105, 2307). However, PPS generally display poor mechanical properties, in particular a low modulus, that limit the true potential of these materials in the biomedical field. Here, we introduce an approach to obtain nanocomposites based on poly(mannitol sebacate) (PMS) matrices reinforced with cellulose nanocrystals (CNCs) in order to improve the application range of these materials. Different strategies were used based on varying the feed ratios between mannitol : sebacic acid (1 : 1 and 1 : 2), crosslinking conditions and CNCs content, resulting in different degrees of crosslinking and, therefore, mechanical and degradation behavior. All of the developed nanocomposites displayed the expected mass loss during the degradation studies in simulated body fluid (SBF) similar to the neat matrix, however, doubling the sebacic acid feed ratio or extending the curing temperature and time, resulted in higher mechanical properties, structural integrity, and shape stability during a degradation time lessening mass loss rate. Changing mannitol : sebacic acid reaction ratios from 1 : 1 to 1 : 2 and for low crosslinking degree neat samples, the Young's modulus increases four-fold, while mass loss after 150 days of incubation is reduced by half. The Young's modulus range obtained with this process covers the range of human elastic soft tissues to tough tissues (0.7-200 MPa). IntroductionIn the past few years, there has been steady progress in the development of biodegradable polymers for application in the medical eld because these materials provide new opportunities to design less invasive and resorbable implants, tissue scaffolds, and medical devices that are able to avoid second revision surgeries, that limit the risk of infection and results in less trauma for the patient.5-8 Moreover, biodegradable polymeric systems which offer the possibility to tailor their mechanical properties from so to stiffer as well as the biodegradability ratio by varying the processing conditions also have additional advantages. Medical devices based on different classes of biodegradable polymers such as polyesters, polyanhydrides and polyurethanes have been widely investigated and some of them are commercially available as resorbable sutures, drug delivery systems, vascular gras, wafers and orthopaedic xation devices based, among others, on polylactic acid (PLA), polyglycolic acid (PGA), poly(lactic-co-glycolic acid) (PLGA), poly(3-caprolactone) (PCL), poly(p-dioxanone) (PDO), or poly(trimethylene carbonate) (PTMC).9,10 However, most of these polymeric systems have degradation rates that are not optimal for short-medium term applications. For example, it takes more than 24 months for poly(caprolactones) and poly(Llactic acid) to degrade in a biological environment, and from 2 to 24 months, depending on the ratio, for copolymers of polylactic acid (PLA) and polyglycolic acid (PGA). Also, the degradation rate for polyanhydrides is slow, around 12 months. 6,9,11 Moreover, these polymers have a lack of exibility and elasticity at bod...

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“…[57] PGS has been fabricated into composites containing multiwalled carbon nanotubes (MWCNT). [58] These composites exhibit comparable macroscopic mechanical properties and cytobiocompatibility. Increased loading of MWCNTs may eventually lead to a percolating network of these conductive elements to form an electronically active PGS composite.…”

Section: Coumarin-functionalized Polyestersmentioning

confidence: 99%

Biodegradable Elastomers for Tissue Engineering and Cell–Biomaterial Interactions

Bettinger¹

2011

Macromolecular Bioscience

118

101

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Synthetic biomaterials serve as a cornerstone in the development of clinically focused regenerative medicine therapies that aim to reduce suffering and prolong life. Recent improvements in biodegradable elastomeric materials utilize natural extracellular matrix proteins as inspiration to yield a new class of materials with superior degradation kinetics, desirable biocompatibility profiles, and mechanical properties that closely match those of soft tissues. This review describes several classes of synthetic biodegradable elastomers and associated fabrication techniques that are relevant to scaffold development. The application of these materials to select tissue engineering models is also discussed.

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Preparation, properties and cytotoxicity evaluation of a biodegradable polyester elastomer composite

Cited by 62 publications

References 53 publications

In vitro cytocompatibility evaluation of alginate dialdehyde for biological tissue fixation

In vitro cytocompatibility evaluation of alginate dialdehyde for biological tissue fixation

Mechanical properties and degradation studies of poly(mannitol sebacate)/cellulose nanocrystals nanocomposites

Biodegradable Elastomers for Tissue Engineering and Cell–Biomaterial Interactions

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