Preparation, optimization and evaluation of Osthole transdermal therapeutic system
MUHAMMAD NAEEM,
TANIYA IQBAL,
MUHAMMAD YOUSUF
et al.
Abstract:In the current study, the solubility and permeability of Osthole-loaded microemulsion were enhanced, which increased bioavailability. In addition, Carbomer 940 was added for prolonged drug delivery. The microemulsion was prepared after the screening of Kukui oil, Labrasol (surfactant), and transcutol-P (co-surfactant).Pseudoternary phase diagrams were employed to find the microemulsion region. Box Behnken Design (BBD) was employed for optimizing microemulsions. Variables were related and compared using mathema… Show more
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