Preparation of Vancomycin-Loaded Aerogels Implementing Inkjet Printing and Superhydrophobic Surfaces

Remuiñán-Pose, Patricia; López‐Iglesias, Clara; Iglesias-Mejuto, Ana; Mano, João F.; García‐González, Carlos A.; Rial-Hermida, M. Isabel

doi:10.3390/gels8070417

Cited by 9 publications

(4 citation statements)

References 53 publications

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“…A continuous flow of 6 g·min −1 of supercritical CO 2 was applied, and the samples were dried for ≈ 4 h. At last, the pressure on the autoclave was slowly decreased (controlled depressurization) until the atmospheric pressure was reached. This methodology was previously reported [ 22 , 23 , 50 ].…”

Section: Methodsmentioning

confidence: 99%

Biological Thermal Performance of Organic and Inorganic Aerogels as Patches for Photothermal Therapy

Ferreira-Gonçalves

Iglesias-Mejuto

Linhares

et al. 2022

Gels

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Aerogels are materials with unique properties, among which are low density and thermal conductivity. They are also known for their exquisite biocompatibility and biodegradability. All these features make them attractive for biomedical applications, such as their potential use in photothermal therapy (PTT). This technique is, yet, still associated with undesirable effects on surrounding tissues which emphasizes the need to minimize the exposure of healthy regions. One way to do so relies on the use of materials able to block the radiation and the heat generated. Aerogels might be potentially useful for this purpose by acting as insulators. Silica- and pectin-based aerogels are reported as the best inorganic and organic thermal insulators, respectively; thus, the aim of this work relies on assessing the possibility of using these materials as light and thermal insulators and delimiters for PTT. Silica- and pectin-based aerogels were prepared and fully characterized. The thermal protection efficacy of the aerogels when irradiated with a near-infrared laser was assessed using phantoms and ex vivo grafts. Lastly, safety was assessed in human volunteers. Both types presented good textural properties and safe profiles. Moreover, thermal activation unveils the better performance of silica-based aerogels, confirming the potential of this material for PTT.

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Section: Methodsmentioning

confidence: 99%

Biological Thermal Performance of Organic and Inorganic Aerogels as Patches for Photothermal Therapy

Ferreira-Gonçalves

Iglesias-Mejuto

Linhares

et al. 2022

Gels

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“…To avoid these drawbacks, solid carriers can be used to improve the therapeutic efficacy and reduce the side effects of the drug [ 25 ]. These solid carriers can enhance contemporary antibacterial treatment for chronic wounds [ 26 ]. The tunable structure and high porosity of Zn-based MOFs facilitate the loading of biological molecules [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Performance of Zr-Based Metal–Organic Framework Materials as In Vitro Systems for the Oral Delivery of Captopril and Ibuprofen

Cretu,

Nicola,

Marinescu

et al. 2023

IJMS

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Zr-based metal–organic framework materials (Zr-MOFs) with increased specific surface area and pore volume were obtained using chemical (two materials, Zr-MOF1 and Zr-MOF3) and solvothermal (Zr-MOF2) synthesis methods and investigated via FT-IR spectroscopy, TGA, SANS, PXRD, and SEM methods. The difference between Zr-MOF1 and Zr-MOF3 lies in the addition of reactants during synthesis. Nitrogen porosimetry data indicated the presence of pores with average dimensions of ~4 nm; using SANS, the average size of the Zr-MOF nanocrystals was suggested to be approximately 30 nm. The patterns obtained through PXRD were characterized by similar features that point to well-crystallized phases specific for the UIO-66 type materials; SEM also revealed that the materials were composed of small and agglomerate crystals. Thermogravimetric analysis revealed that both materials had approximately two linker deficiencies per Zr6 formula unit. Captopril and ibuprofen loading and release experiments in different buffered solutions were performed using the obtained Zr-based metal–organic frameworks as drug carriers envisaged for controlled drug release. The carriers demonstrated enhanced drug-loading capacity and showed relatively good results in drug delivery. The cumulative percentage of drug release in phosphate-buffered solution at pH 7.4 was higher than that in buffered solution at pH 1.2. The release rate could be controlled by changing the pH of the releasing solution. Different captopril release behaviors were observed when the experiments were performed using a permeable dialysis membrane.

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“…Recently, various separation materials with special wettability such as membrane films, porous materials, and gelation have been widely developed [7][8][9][10][11][12]. Superhydrophilic materials with hierarchical structures and water-binding affinity could adsorb water and make water become trapped in the rough structures once contacting water during the separation process [13,14].…”

Section: Introductionmentioning

confidence: 99%

Superhydrophobic/Superoleophilic PDMS/SiO2 Aerogel Fabric Gathering Device for Self-Driven Collection of Floating Viscous Oil

Liu,

Di,

Sun

et al. 2023

Gels

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The persistent challenge of removing viscous oil on water surfaces continues to pose a major concern and requires immediate attention. Here, a novel solution has been introduced in the form of a superhydrophobic/superoleophilic PDMS/SiO2 aerogel fabric gathering device (SFGD). The SFGD is based on the adhesive and kinematic viscosity properties of oil, enabling self-driven collection of floating oil on the water surface. The SFGD is able to spontaneously capture the floating oil, selectively filter it, and sustainably collect it into its porous fabric interior through the synergistic effects of surface tension, gravity, and liquid pressure. This eliminates the need for auxiliary operations such as pumping, pouring, or squeezing. The SFGD demonstrates exceptional average recovery efficiencies of 94% for oils with viscosities ranging from 10 to 1000 mPa·s at room temperature, including dimethylsilicone oil, soybean oil, and machine oil. With its facile design, ease of fabrication, high recovery efficiency, excellent reclaiming capabilities, and scalability for multiple oil mixtures, the SFGD represents a significant advancement in the separation of immiscible oil/water mixtures of various viscosities and brings the separation process one step closer to practical application.

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Preparation of Vancomycin-Loaded Aerogels Implementing Inkjet Printing and Superhydrophobic Surfaces

Cited by 9 publications

References 53 publications

Biological Thermal Performance of Organic and Inorganic Aerogels as Patches for Photothermal Therapy

Biological Thermal Performance of Organic and Inorganic Aerogels as Patches for Photothermal Therapy

Performance of Zr-Based Metal–Organic Framework Materials as In Vitro Systems for the Oral Delivery of Captopril and Ibuprofen

Superhydrophobic/Superoleophilic PDMS/SiO2 Aerogel Fabric Gathering Device for Self-Driven Collection of Floating Viscous Oil

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