Preparation of uniform-sized exenatide-loaded PLGA microspheres as long-effective release system with high encapsulation efficiency and bio-stability

Qi, Feng; Wu, Jie; Fan, Qingze; He, Fan; Tian, Guifang; Yang, Tingyuan; Ma, Guanghui; Su, Zhiguo

doi:10.1016/j.colsurfb.2013.08.048

Cited by 88 publications

(60 citation statements)

References 36 publications

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“…PVA is a water-soluble non-ionic surfactant that is widely used as a stabilizer in the preparation of particles by avoiding the droplet coalescence during emulsification and subsequent solidification process [13,14]. It is evident from the results that increasing PVA concentration (F4 vs F5) did not significantly affected the mean microsponge size; however, there was a significant decrease in the size distribution of the microsponges.…”

Section: Fig 1: Images Of Different Formulations Of Microsponges Takmentioning

confidence: 45%

“…It is evident from the results that increasing PVA concentration (F4 vs F5) did not significantly affected the mean microsponge size; however, there was a significant decrease in the size distribution of the microsponges. Earlier, Qi et al [14] also reported an similar findings who prepared exenatide-loaded poly(d,l-lactic-co-glycolic acid) (PLGA) microspheres through premix membrane emulsification. According to their finding, a large size distribution at low PVA concentration is due to broken particles in the absence of proper stabilization.…”

Section: Fig 1: Images Of Different Formulations Of Microsponges Takmentioning

confidence: 58%

“…Distilled water was used for the preparation of solutions. [11][12][13][14][15]. The organic internal phase consisted of the certain amount of Eudragit ® RS 100 polymer dissolved in organic solvent (acetone or dichloromethane).…”

Section: Chemicalsmentioning

confidence: 99%

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Preparation of Ascorbic Acid and Cholecalciferol Microsponges for Topical Application

Zia

Nazir

Khan

et al. 2017

Int J Pharm Pharm Sci

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Objective: Apart from having various physiological functions in the body, ascorbic acid (vitamin C) and cholecalciferol (vitamin D3) also have a key role in skin protection. However, their bioavailability is quite limited in the skin, and therefore, many cosmetic products are supplemented with these vitamins, which are usually associated with stability issues. To avoid these issues, here we report on the preparation of microsponges of these vitamins for topical application. Methods:The microsponges were prepared through various emulsification-solvent evaporation methods involving singleThe organic internal phase was consisted of Eudragit ® RS 100 polymer dissolved in an organic solvent such as acetone or dichloromethane, at a constant polymer to drug ratio of 2:1. The prepared microsponges were characterized for their entrapment efficiency, droplet size and uniformity, core to wall interaction, and surface morphology.Results: It was found that the W/O/W and S/O/W are suitable methods for the preparation of vitamin C microsponges and O/W is a suitable method for the preparation of vitamin D3 microsponges; ensuring an encapsulation efficiency of around 56-59% and 93%, respectively. The average diameter of vitamin C and D3 microsponges was typically around 56-68 μm and 48 μm, respectively. Conclusion:It is possible to encapsulate both water and oil soluble vitamins in a microsponge system at an appreciable entrapment efficiency. The findings of the present study are expected to play a vital role in the development of cosmeceuticals.

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Section: Fig 1: Images Of Different Formulations Of Microsponges Takmentioning

confidence: 45%

Section: Fig 1: Images Of Different Formulations Of Microsponges Takmentioning

confidence: 58%

See 1 more Smart Citation

Preparation of Ascorbic Acid and Cholecalciferol Microsponges for Topical Application

Zia

Nazir

Khan

et al. 2017

Int J Pharm Pharm Sci

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“…In this regard, effect of various independent variables, such as polymer/cross-linker concentration, sonication time, stirring speed, cross-linking time has been investigated over the obligatory responses (Cui et al, 2006;Graf et al, 2009). Furthermore, native structure of proteins/peptides, like Glucagon-like peptide 1 (GLP-1), GLP-1 receptors agonist (GLP1RAs) get modified when administered orally, therefore modification of its surface becomes the obligatory step in delivering these drugs before administering (Qi et al, 2013). Lipophilicity and poor water solubility of some oral hypoglycemics, like glibenclimide offered other challenges to the formulation scientist, viz.…”

Section: Metforminmentioning

confidence: 99%

“…Literature unfolds various types of traditional liposomes, such as uni-lamellar (ULV) or multi-lamellar vesicular systems (MLV) (Ye et al, 2000;Karathanasis et al, 2006). Drugs/actives like cytotoxic, antidiabetics, anti-cancerous, proteinaceous and genetic material have been encapsulated in liposomal systems and it has been (Liu et al, 2010;Ryan et al, 2013;Qi et al, 2013;Xuan et al, 2013) …”

Section: Liposomesmentioning

confidence: 99%

Novel drug delivery system: an immense hope for diabetics

et al. 2014

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Context: Existing medication systems for the treatment of diabetes mellitus (DM) are inconvenient and troublesome for effective and safe delivery of drugs to the specific site. Therefore, investigations are desired to deliver antidiabetics using novel delivery approaches followed by their commercialization. Objective: The present review aims to provide a compilation on the latest development in the field of novel drug delivery systems (NDDSs) for antidiabetics with special emphasis on particulate, vesicular and miscellaneous systems. Methods: Review of literature (restricted to English language only) was done using electronic databases like Pubmed Õ and Scirus, i.e. published during [2005][2006][2007][2008][2009][2010][2011][2012][2013]. The CIMS/MIMS India Medical Drug Information eBook was used regarding available marketed formulation of antidiabetic drugs. Keywords used were ''nanoparticle'', ''microparticle'', ''liposomes'', ''niosomes'', ''transdermal systems'', ''insulin'', ''antidiabetic drugs'' and ''novel drug delivery systems''. Single inclusion was made for one article. If in vivo study was not done then article was seldom included in the manuscript. Results: The curiosity to develop NDDSs of antidiabetic drugs with special attention to the nanoparticulate system followed by microparticulate and lipid-based system is found to emerge gradually to overcome the problems associated with the conventional dosage forms and to win the confidence of end users towards the higher acceptability. Conclusion: In the current scientific panorama when the area of novel drug delivery system has been recognized for its palpable benefits, unique potential of providing physical stability, sustained and site-specific drug delivery for a scheduled period of time can open new vistas for precise, safe and quality treatment of DM.

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Rapid Membrane Emulsification Process for Preparation of Small Microspheres

2023

Novel Membrane Emulsification

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Preparation of uniform-sized exenatide-loaded PLGA microspheres as long-effective release system with high encapsulation efficiency and bio-stability

Cited by 88 publications

References 36 publications

Preparation of Ascorbic Acid and Cholecalciferol Microsponges for Topical Application

Preparation of Ascorbic Acid and Cholecalciferol Microsponges for Topical Application

Novel drug delivery system: an immense hope for diabetics

Rapid Membrane Emulsification Process for Preparation of Small Microspheres

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