Preparation of two steroid derivatives and its theoretical interaction with a 17β‐hydroxysteroid dehydrogenase type 1
Abstract:The aim of this study was synthesizing two steroid derivatives to evaluate their theoretical interact with a 17β‐hydroxysteroid dehydrogenase type 1. The first stage was achieved by the preparation of a steroid-imino analog (compound 2) using a reaction of imination and ii) etherification. Then, the theoretical interact of two steroid analogs with 17β‐hydroxysteroid dehydrogenase type 1 (1IOL) was evaluated using fisetin and methyl paraben as controls in a docking model. The results suggest that steroid deriv… Show more
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