Preparation of two‐dimensional porphyrin‐based MOFs/derivatives and their potential in sensing and biomedical applications

Abstract

Two‐dimensional Porphyrin‐based MOFs (2D p‐MOFs) and their derivatives have demonstrated significant potential in sensing and biomedical applications with their development and optimization expected to lead to significant advances in these fields. However, achieving a high quality of 2D p‐MOFs remains the present research rub and challenge. This review covers various methods and compound strategies for preparing 2D p‐MOFs including both bottom‐up and top‐down approaches, both of which have drawbacks that need to be addressed, and also summarizes their advantages for the obtained prepared 2D p‐MOF. Meanwhile, we review the different ways of functionalizing 2D porphyrin‐based MOF nanosheets with examples. It also highlights the crucial role of 2D p‐MOFs and derivatives in sensing applications, including food safety inspection, biomedical sensing, and environmental testing. Finally, the review summarizes the medical treatment based on 2D p‐MOFs, including drug delivery, photodynamic therapy (PDT), photothermal therapy, imaging, and more, further emphasizing the value of 2D p‐MOFs and derivatives.

Controlled-Release Electrochemiluminescence Biosensor with Strong Self-On Effect by a Multiple Signal Amplification Strategy for Trace Detection of Prostate-Specific Antigen

“…10 Zeolitic imidazolate framework-8 (ZIF-8), due to its large surface area and chemical stability, 10,11 was adopted to load luminol, thereby improving the stability of the controlled-release electrochemiluminescence (CRE) biosensor. 12,13 The coreactant can promote the luminophore into an excited state to increase the ECL signal. H 2 O 2 is the most commonly coreactant of luminol, which produces free radicals that can oxidize luminol to excited amino phthalate (AP 2− *), 14 resulting in a significant ECL signal.…”

“…Therefore, the idea of framework-enhanced stability was introduced to enhance the stability of the luminol . Zeolitic imidazolate framework-8 (ZIF-8), due to its large surface area and chemical stability, , was adopted to load luminol, thereby improving the stability of the controlled-release electrochemiluminescence (CRE) biosensor. , …”

Anisotropic growth of gold anchors on CdSe semiconductor quantum platelets for self-assembled architectures with well-connected electronic circuits for the electrochemical detection of enrofloxacin

“…In electrochemical sensors, the electroactive or catalytic matrixes on the electrode surface are known to determine the analytical performance. 8–12 The coupling of semiconductors and metals has been reported because they can work in synergy to produce a superior electrochemical response to either of them alone, and they show great advantages in charge separation and transport at metal–semiconductor (M–S) junctions. 13,14 Thus, a wide variety of such hetero-systems have sprung up, from II–VI semiconductors (CdSe, CdSe/CdS) to metal oxides (TiO 2 , ZnO), polymers (g-C 3 N 4 ), and so forth, in the semiconductor realm, and from precious to transition metals and many more in the metal field.…”

Editorial: Smart nanomaterials for biosensing and therapy applications, volume II

“…The construction of nanomedicine systems has always been a key factor affecting the effectiveness of nanomedicine in tumor treatment (Chen et al, 2022;Zhou et al, 2022;Wang et al, 2023a;Wang et al, 2023b). Zhang et al successfully summarized the advantages and disadvantages of nanomedicine systems currently used for the treatment and diagnosis of esophageal cancer, and proposed multiple excellent suggestions for the development of nanomedicine systems in the future.…”