Preparation of Titanocene–Gold Compounds Based on Highly Active Gold(I)‐N‐Heterocyclic Carbene Anticancer Agents: Preliminary in vitro Studies in Renal and Prostate Cancer Cell Lines

Abstract

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Evaluating Ligand Modifications of the Titanocene and Auranofin Moieties for the Development of More Potent Anticancer Drugs

“…An intriguing approach to exploit the distinct cytotoxic mechanism of action of Ti(IV) and Au(I) is synergizing their activity in the form of heterometallic compounds [115][116][117][118][119][120][121][122]. These compounds build off of the titanocene structure.…”

Comparative biological evaluation and G-quadruplex interaction studies of two new families of organometallic gold(I) complexes featuring N-heterocyclic carbene and alkynyl ligands

“…Moreover, the NHC core structure can be chemically modified conferring different physicochemical and functional properties to the resulting metallopharmaceutical. Thus, since their first report, several gold(I) NHC complexes have been shown to possess promising cytotoxic properties against cancer cells, or even antibacterial effects [13][14][15][16][17][18][19][20][21][22][23][24]. The proposed mechanism of action of this class of oganometallic complexes has been linked…”

Synthetic Strategy Towards Heterodimetallic Half-Sandwich Complexes Based on a Symmetric Ditopic Ligand

“…Alternatively, scaffold structures can be adopted to form dimetallic species of greater complexity. Relevant examples include a trimeric scaffold consisting of alkylated 1,3,5-triaza-7-phosphaadamantane moieties or other phosphine or nitrogen donor-based ligand systems ( Burgoyne et al, 2016 ; Batchelor et al, 2019 ; Curado et al, 2019 ). Moreover, tetra- and octanuclear Ir and Rh complexes can be created using dendritic structures that have Schiff-base ligands based on poly(propyleneimine) scaffolds ( Payne et al, 2013 ).…”