Preparation of TiO 2 nanotubes/mesoporous calcium silicate composites with controllable drug release

Facile synthesis of novel calcium silicate hydrated-nylon 6/66 nanocomposites by solution mixing method

“…The specic surface area obtained was 343.99 m 2 g À1 , this result can ensure a higher bioactivity due to the increase of sites for formation of Hap; also the presence of mesoporous is a suitable characteristic for biomaterials for bone regeneration because they allow the free movement of biomolecules like proteins and induce the adhesion of cells. 8,[26][27][28] The SEM image shown in Fig. 3B suggests that the CSH consists of agglomerated nanoparticles and it has high porosity.…”

“…1 In addition to the characteristics mentioned above, the biomaterials should have good mechanical properties and be easily processed to make different pieces such as bone prosthesis or dental implants that are more durable and efficient than the ones made with conventional materials. [7][8][9][10][11] Ceramic materials are fragile and are not suitable for use in applications that require high load. In order to improve its mechanical properties, composite materials of ceramics with polymers like chitosan, polyamides and polycaprolactone have been studied as biomaterials.…”

NanoZnO-modified titanium implants for enhanced anti-bacterial activity, osteogenesis and corrosion resistance

“…However, there are still many doubts and conflicting opinions on several aspects of using antibiotic implants after years of scientific debate, because of mutant resistance produced by long-term exposure to antibiotics below the inhibitory concentration, serious side effects, and other factors [ 128 ]. Ti implants topically loaded with antibiotics can provide sustained drug release, but non-specific release and local overdose issues make them detrimental to long-term antimicrobial action [ 129 ]. Designs with condition-response mechanisms are likely to be considered as a more refined solvent [ 130 , 131 ].…”

Approaches based on passive and active antibacterial coating on titanium to achieve antibacterial activity

“…A thin film, such as CS, can be coated onto the Ti nanotube surface to control antibiotics release . Mesoporous calcium silicate composite immobilization on Ti nanotubes may improve the release profile of drugs by reducing burst release and sustaining overall release . The drug release rate from the titanium nanotube depends on the diameter of the nanotube and rate of water penetration into the nanotube.…”