Preparation of tiny biodegradable capsules using electrocapillary emulsification

Abstract

Conditions for preparing tiny biodegradable capsules were examined using electrocapillary emulsification that allows one to prepare monodisperse emulsions with ease by applying a DC potential between oil and water phases without mechanical agitation. The results obtained showed that a 1 : 4 mixture of polysorbate 80 (TO-10), a hydrophilic non-ionic surfactant, and sorbitan monooleate (SO-10), an oleophilic surfactant, is appropriate as the surfactant to be added to oil phase, cyclohexane is acceptable as the oil phase and 1000 V is optimum as the DC potential to be applied. The capsules prepared had sizes ranging from 100-300 nm and a surface roughness of approximately 10 nm and degraded in model intestinal juice more easily and rapidly than in model gastric juice. In addition, the capsules containing lactoferrin, an anti-carcinogenic protein, were found to keep 12.5% of the protein used in encapsulation without losing its activity.

Preparation of polyurea capsules using electrocapillary emulsification

“…W/O emulsions were prepared with the laboratory-made apparatus for electrocapillary emulsification [7,8]. Briefly, the apparatus consists of the emulsification part, the applied electric potential and liquid dropping rate controlling part, a CCD camera and a monitor.…”

Approach for Dispersing a Hydrophilic Compound as Nanoparticles Into Soybean Oil Using Evaporation Technique

“…Furthermore, decreasing the particle size in the dispersed water phase is necessary. Much pharmaceutical technical information about adjusting the size of particles is now available: for example, rotating membrane emulsification [1,2], shirasu porous glass membrane emulsification [3,4], electrocapillary emulsification [5,6]. These methods adjust particle size on the basis of membrane pore size and shearing force, which depends on the flow of dispersion medium or on contact-surface dielectric constant differences between the dispersion medium and the dispersion phase.…”

Chitosan nano‐spheres production by electrostatic emulsification technique

“…The electrostatic atomization is a technique for the atomization of liquid with an electrohydrodynamic (EHD) force, and many studies are reported in recent years . The electrostatic atomization could be classified into three systems as follows: (1) a liquid dispersion into a gas (L/G) system, (2) gas dispersion into a liquid (G/L) system, and (3) a liquid dispersion into a liquid (L/L) system.…”

“…As mentioned earlier, although electrostatic emulsification has potential ability to prepare a uniform nano‐size droplet, reports on the production of drug carrier are few. Some attempts for the drug carrier production were conducted by Abe et al , such as the nano‐capsule of alginate/polylysine complex, which has sizes ranging from 100–500 nm, the Poly(2‐ethylcyanoacrylate), which has sizes ranging from 100–300 nm, and the poly‐urea capsule of around 200 nm …”