Preparation of Thermosensitive Microcapsules Containing Water Soluble Powder by Melting Dispersion Cooling Method

Taguchi, Yoshinari; Saito, Natsukaze; Uchida, Atsunori

doi:10.4236/jeas.2016.63006

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…In the case of Process A, as the microcapsules were prepared by using the (W/O)/W emulsion, the dye aqueous solution may be easily released on breaking the (W/O) emulsion into the continuous water phase and on forming the (W/O) droplets [22]. As a result, the microencapsulation efficiency may become low (λ = ca.…”

Section: Microencapsulation Efficiency For Each Microcapsulementioning

confidence: 99%

Preparation of Microcapsules Containing Dye Aqueous Solution and Investigation of Release Feature According to Preparation Method

Taguchi¹,

Saito²

2017

JEAS

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Microcapsules containing the dye aqueous solution were prepared with three kinds of preparation methods and the release feature of microcapsules with each preparation method was mainly investigated. As a dye tried to microencapsulate, methylene blue was adopted, because methylene blue aqueous solution was changed in color with light irradiation and utilized in order to check the degree of river pollution. Microencapsulation using multiple emulsion was performed with the suspension polymerization method, the inverse interfacial polycondensation method and the suspension polymerization in parallel with the interfacial polymerization method, respectively. The release feature of microcapsules prepared with each preparation method was estimated with the solute permeability coefficient. It was found that the release feature of dye aqueous solution was different according to the preparation method and could be delicately controlled by microencapsulating with the suspension polymerization in parallel with interfacial polycondensation reaction and forming the polyurethane shell on the surface of the dye aqueous solution droplets.

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Section: Microencapsulation Efficiency For Each Microcapsulementioning

confidence: 99%

Preparation of Microcapsules Containing Dye Aqueous Solution and Investigation of Release Feature According to Preparation Method

Taguchi¹,

Saito²

2017

JEAS

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Microencapsulation of curcumin by spray drying and freeze drying

Guo

Kong

et al. 2020

LWT

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Genomic characterization, in vitro, and preclinical evaluation of two microencapsulated lytic phages VB_ST_E15 and VB_ST_SPNIS2 against clinical multidrug-resistant Salmonella serovars

Youssef,

Sakr,

Shebl

et al. 2024

Ann Clin Microbiol Antimicrob

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Background Salmonella infections continue to be one of the essential public health issues threatening millions of people. With the increasing occurrence of resistance against conventionally used antibiotics, the search for alternatives has become crucial. In this study, we aimed to isolate, characterize, and evaluate two lytic bacteriophages against clinically isolated multidrug-resistant (MDR) Salmonella serovars. Methods Screening for the phage lytic activity was performed using a spot test. Characterization of the isolated phages was done by determining the host range, longevity test, and the effect of temperature, pH, organic solvents, and morphological characterization using a transmission electron microscope. Genomic analysis was performed using Oxford nanopore sequencing. The lytic activities of the free phage lysates and formulated phage as microencapsulated were evaluated both in vitro and in vivo. Results Two phages (VB_ST_E15 and VB_ST_SPNIS2) were successfully isolated and showed lytic strong activities against MDR Salmonella (S.) Typhimurium ATCC 14,028, S. Paratyphi A, and S. Typhi. The two phages survived at the tested temperatures, maintained their infectivity for 90 days, and retained their activity until 60 °C with thermal inactivation at 65 °C. They were lytic at a pH range from 3 to 11 but lost their activities at extremely acidic or alkaline pH. The phages could withstand the organic solvents but were completely inactivated by 100% ethanol. Both phages were classified under the order Caudoviricetes, and Genus: Uetakevirus. Their genomic sequences were assembled, annotated, and submitted to the NCBI GenBank database (OR757455 and OR757456). The preclinical evaluation using the murine animal model revealed that the two-phage cocktail managed MDR Salmonella infection as evidenced by the reduction in the bacterial burden, increased animal weight, and histopathological examination. Conclusion The two encapsulated phage formulas could be considered promising candidates for the management of MDR Salmonella-associated infections and clinical analysis should be undertaken to evaluate their potential use in humans.

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Preparation of Thermosensitive Microcapsules Containing Water Soluble Powder by Melting Dispersion Cooling Method

Cited by 3 publications

References 21 publications

Preparation of Microcapsules Containing Dye Aqueous Solution and Investigation of Release Feature According to Preparation Method

Preparation of Microcapsules Containing Dye Aqueous Solution and Investigation of Release Feature According to Preparation Method

Microencapsulation of curcumin by spray drying and freeze drying

Genomic characterization, in vitro, and preclinical evaluation of two microencapsulated lytic phages VB_ST_E15 and VB_ST_SPNIS2 against clinical multidrug-resistant Salmonella serovars

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