Preparation of thermosensitive gold nanoparticles by plasma pretreatment and UV grafted polymerization

Chen, Ko-Shao; Hung, Tsui-Shan; Wu, Haoming; Wu, Jen-Yuan; Lin, Ming-Tse; Feng, Chi-Kuang

doi:10.1016/j.tsf.2010.05.043

Cited by 20 publications

(12 citation statements)

References 18 publications

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“…A new technique of photochemical method has been reported for the preparation of gold-polyethylene glycol core-shell nanoparticles with size 10 -50 nm in water by adopting redox and polymerization reactions. In this method gold salt was reduced by radical formation coated with polyethylene glycol diacrylate by UV-process with the help of photo-initiator 2-hydroxy-2-methyl-1-phenyl-1-propane [35]. Gold nanoparticles are also synthesized by using seed approach.…”

Section: Physical Methodsmentioning

confidence: 99%

“…Indium tin oxide electrode modified with gold nanoparticles/TiO 2 composites has been used for the estimation of catechol (CC) and hydroquinone (HQ) with the help of voltametric method. Catechol has been successfully determined in tea sample by adopting this method [35]. Another important application of gold nanoparticles is in memory devices.…”

Section: Strain Sensorsmentioning

confidence: 99%

“…Primary goal of developing anticancer agents is to minimize the various side effects caused by the conventional drugs and to improve selectivity and efficiency of drug [35]. Targeted drug delivery is the main area of interest for scientists recently and a lot of work has been done to synthesized systems for targeted drug delivery such as nanoparticles, quantum dots, polymer gels, Fe 3 O 4 , and ZnO [18].…”

Section: Gold Nanoparticle-mediated Drug Deliverymentioning

confidence: 99%

See 2 more Smart Citations

Gold Nanoparticles: Synthesis and Applications in Drug Delivery

Ak¹,

Rashid²,

Murtaza³

et al. 2014

Trop. J. Pharm Res

375

163

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This review is focused essentially on the synthesis and applications of gold nanoparticles in the field of medicine and targeted drug delivery. Nanotechnology has become one of the most interesting and advanced areas of research in this field. Among nanoparticles, gold nanoparticles demonstrate special advantages in this field due to their unique properties, small size and high surface area-to-volume ratio.These particles have been widely used in various biomedical applications and drug delivery systems due to their inert nature, stability, high dispersity, non-cytotoxicity and biocompatibility.

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Section: Physical Methodsmentioning

confidence: 99%

Section: Strain Sensorsmentioning

confidence: 99%

Section: Gold Nanoparticle-mediated Drug Deliverymentioning

confidence: 99%

See 1 more Smart Citation

Gold Nanoparticles: Synthesis and Applications in Drug Delivery

Ak¹,

Rashid²,

Murtaza³

et al. 2014

Trop. J. Pharm Res

375

163

View full text Add to dashboard Cite

show abstract

“…Advanced plasma system (Model PD-2S plasma deposition system manufactured by SAMCO Company) with 13.6 MHz radio frequency generator and a bell jar type reactor were used to activate the surfaces of the films. All process of the cold plasma treatment was described in detail in previous study [42]. Foremost, samples were treated by placed over the electrode, a horizontal holder, and the chamber was pumped to a base pressure of 30 mtorr before the cold plasma treatment which was stabilized.…”

Section: Cold Plasma Of Surface Treatmentmentioning

confidence: 99%

“…Hence, TPU surface is hard to bind with polar surface of material (collagen, enzyme, cell, chitosan), leading easy to peel off objective. For this reason, plasma technologies [39] (corona [40], glow [41], photo-grafting, UV induced and graft polymerization [42,43]) have been used to modify the surface of TPU. It is a very effective way to promote hydrophilicity of TPU surface by applying free radicals, peroxides (OOR, OOH), and functional groups (SiO 2 , CH 3 , OH, COOH, C=O, and NH 2 [44]) introduced by plasma or grafting of gas or monomers [45] such as O 2 [46,47], He, Ar [48,49], N 2 , CH 4 , C 2 H 2, CO 2 , acetic acid, acrylic acid [50,51], N-isopropylacrylamide (NIPAAm) [52], hexamethyldisilazane (HMDSZ), isopropanol.…”

Section: Introductionmentioning

confidence: 99%

Chitosan/ Alginate /Gellan Gum Hybrid Hydrogel as a Vehicle for Controlled Release of Drug

Pan¹

2019

IJBMR

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Hybrid hydrogel was fabricated by a classic sol-gel method using EDC/NHS as crosslink reagent grafting onto the thermoplastic polyurethane (TPU), nonwoven fabric, for controlled release of drug. In this study, precursor acetic acid (AA) was used to plasma deposit on the surface of TPU to form a hydrophilic thin film. Hybrid hydrogel was investigated through scanning electron microscopy (SEM), water contact angle (WCA) measurement, Fourier transform infra-red (FTIR) spectroscopy, UV/V is spectroscopy, equilibrium swelling ratio, MTT assay and drug delivery system studies. This polyelectrolyte complexes (PECs) formed hydrogel, pH-sensitive type, was evaluated at pH value of 1.2 and 7.4 of buffer solution and at temperature of 37°C to observe its rate of swelling and drug release features with caffeine. Moreover, the mechanism of caffeine release from membrane devices (n=0.58) are anomalous transport, non-Fickian diffusion, the value of n lies between 0.43 and 0.85. It has an excellent release ratio up to about 90% absorption cumulative amounts of caffeine at pH 7.4 after 8h and could be a beneficial carrier for fragile drugs.

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Polyurethane membranes with tunable surface properties for biomedical applications

Ignacio

Gomes

Oréfice

2011

J of Applied Polymer Sci

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The use of surfaces with tunable properties triggered by external stimuli is effective in controlling the interactions between biomaterials and biological entities, such as proteins and cells. The goal of this work is to prove that the presence of poly-n-isopropylacrylamide (P-N-IPAAm) chains grafted onto polyurethane (PU) membranes and used for medical wound dressings can allow the behavior of the surfaces to be shifted from hydrophobic to hydrophilic by reducing the temperature to values lower than the low critical solution temperature (LCST) of the polymer, which is close to 32 C. The manipulation of this behavior can then be used to control cell and protein adhesion on the surface. Grafting of P-NIPAAm was accomplished by treating the surface of polyurethane membranes with ultraviolet (UV) radiation, followed by polymerizing the isopropylacrylamide from the modified surfaces. The wettability of the surfaces was studied using contact angle measurements as a function of temperature. Infrared spectroscopy was also used to characterize these modified surfaces. The ability of the grafted surfaces to allow adsorption of proteins was evaluated as a function of temperature. The results showed that the amount of proteins adsorbed on the polyurethane membranes could be radically changed by altering the temperature above or below 32 C. In vivo biocompatibility tests were performed on P-N-IPPAm samples, and no indication of toxicity was noted after 7 days of implantation.

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Preparation of thermosensitive gold nanoparticles by plasma pretreatment and UV grafted polymerization

Cited by 20 publications

References 18 publications

Gold Nanoparticles: Synthesis and Applications in Drug Delivery

Gold Nanoparticles: Synthesis and Applications in Drug Delivery

Chitosan/ Alginate /Gellan Gum Hybrid Hydrogel as a Vehicle for Controlled Release of Drug

Polyurethane membranes with tunable surface properties for biomedical applications

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