Preparation of thermoresponsive nanoparticles exhibiting biomolecule recognition ability via atom transfer radical dispersion polymerization

Matsuyama, Tomohiro; Hayashi, Hiroyuki; Komatsu, Syuuhei; Asoh, Taka‐Aki; Kikuchi, Akihiko

doi:10.1016/j.colsurfb.2019.110370

Cited by 10 publications

(3 citation statements)

References 26 publications

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“…Polymeric nano- and microparticles have been applied in a variety of fields, especially in biomedical applications such as drug delivery, − imaging, , and diagnostic carriers, , because of their large surface areas and simple surface functionalization. − Various types of polymeric particles have been developed using variety types of materials with stimuli-responsive and biodegradable properties. , In addition, controlling the interactions between particles and cells, such as endocytosis and phagocytosis, is a key issue for drug delivery system (DDS) carriers. The particle size and shape affect cellular uptake.…”

Section: Introductionmentioning

confidence: 99%

“…Polymeric nano- and microparticles have been applied in a variety of fields, especially in biomedical applications such as drug delivery, 1 − 3 imaging, 4 , 5 and diagnostic carriers, 6 , 7 because of their large surface areas and simple surface functionalization. 8 − 11 Various types of polymeric particles have been developed using variety types of materials with stimuli-responsive and biodegradable properties.…”

Section: Introductionmentioning

confidence: 99%

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Preparation of Degradable and Transformable Core–Corona-Type Particles that Control Cellular Uptake by Thermal Shape Change

Komatsu,

Yamada,

Kikuchi

2024

ACS Biomater. Sci. Eng.

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Particle–cell interactions, such as cellular uptake, vary depending on the particle size, shape, and surface properties. By dynamic control of the physical properties of particles, microparticle–cell interactions can intentionally be altered. Particle degradability is also necessary for their application in the body. In this study, we aimed to prepare degradable core–corona-type particles that are deformed near the body temperature and investigated particle shape-dependent cellular uptake. Degradable and transformable particles consisting of poly(2-methylene-1,3-dioxepane)-co-poly(ethylene glycol) with three-armed poly(ε-caprolactone) (PCL) were prepared. The particle melting point was controlled by the chain length of the three-armed PCL. Particle degradation occurred under both acidic and alkaline conditions via ester group hydrolysis in the polymer backbones. The rod-shaped microparticles prepared by uniaxial stretching at a temperature above the melting point of the core showed less uptake into macrophages than did the spherical microparticles. Therefore, the degradable transformable particles enable macrophage interaction control via stimuli-regulated particle shapes and are expected to be applied as drug delivery carriers that can be decomposed and excreted from the body.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preparation of Degradable and Transformable Core–Corona-Type Particles that Control Cellular Uptake by Thermal Shape Change

Komatsu,

Yamada,

Kikuchi

2024

ACS Biomater. Sci. Eng.

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“…Stimuli‐responsive polymers that undergo phase transitions in response to externally stimuli factors, such as pH, heat, light, or magnet, are playing an increasingly important role in catalysis 5–7 . Catalysts combined with thermo‐responsive polymers are highly appealing because of the accessibility and operability of heat stimuli by simply heating or cooling the system 8–10 . Among them, poly( N ‐isopropylacrylamide) (PNIPAM) is a commonly studied thermo‐responsive polymer, which demonstrates a phase transition at a lower critical solution temperature (LCST) around 32–33°C.…”

Section: Introductionmentioning

confidence: 99%

Thermo‐responsive block copolymer micelle‐supported (S)‐α,α‐diphenylprolinol trimethylsilyl ether for asymmetric Michael addition of nitroalkenes and aldehydes in water

Wang

et al. 2020

J of Applied Polymer Sci

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An amphiphilic block copolymer PNIPAM53‐b‐(PS30‐co‐P4AMS10) was facilely prepared by reversible addition‐fragmentation chain transfer (RAFT) polymerization. The immobilization of (S)‐α,α‐diphenylprolinol trimethylsilyl ether onto the block copolymers was then performed through using copper‐catalyzed alkyne‐azide cycloaddition (CuAAC), and the generating amphiphilic diblock copolymer supported chiral catalyst PNIPAM53‐b‐(PS30‐co‐P4AMS10)/proTMS was self‐assembled into micelles with regular diameters about 50 nm in aqueous solution. The micellar catalyst was further used for the asymmetric Michael reaction between propanal and trans‐β‐nitrostyrene in water. Using only 1 mol% micellar catalyst, the corresponding Michael addition products could be obtained in good yields and high enantioselectivities as well as good diastereoselectivities. In addition, this micellar catalyst could be reused at least for four times. Moreover, the micellar catalyst could be applied for the asymmetric addition reaction of 4‐chlorocinnamyl aldehyde and nitromethane, and thus constructing the baclofen pharmaceutical intermediate.

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Introduction

Haider

Ikram²,

Rafiq³

2022

Green Nanomaterials as Potential Antimicrobials

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Preparation of thermoresponsive nanoparticles exhibiting biomolecule recognition ability via atom transfer radical dispersion polymerization

Cited by 10 publications

References 26 publications

Preparation of Degradable and Transformable Core–Corona-Type Particles that Control Cellular Uptake by Thermal Shape Change

Preparation of Degradable and Transformable Core–Corona-Type Particles that Control Cellular Uptake by Thermal Shape Change

Thermo‐responsive block copolymer micelle‐supported (S)‐α,α‐diphenylprolinol trimethylsilyl ether for asymmetric Michael addition of nitroalkenes and aldehydes in water

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