Preparation of thermally denatured albumin gel and its pH-sensitive swelling

Park, Ham Yong; Song, In Ho; Kim, Jung Hyun; Kim, Woo Sik

doi:10.1016/s0378-5173(98)00289-0

Cited by 63 publications

(26 citation statements)

References 13 publications

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“…In traditional drug delivery systems, the rate of these processes is often controlled by altering polymer composition, 6 matrix topology, 26 and crosslinking density. 15 To provide additional tunability, delivery systems responsive to external stimuli, such as changes in pH, 16,17 temperature, 2,14 and glucose concentration, 7,12 have also been developed. These self-regulatory systems have the potential to adjust the rate of drug release in response to physiological needs.…”

Section: Introductionmentioning

confidence: 99%

Experimental Studies and Modeling of Drug Release from a Tunable Affinity-Based Drug Delivery Platform

Thatiparti

Saidel

et al. 2011

Ann Biomed Eng

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An affinity-based drug delivery platform for controlling drug release is analyzed by a combination of experimental studies and mathematical modeling. This platform has the ability to form selective interactions between a therapeutic agent and host matrix that yields advantages over systems that employ nonselective methods. The incorporation of molecular interactions in drug delivery can increase the therapeutic lifetime of drug delivery implants and limit the need for multiple implants in treatment of chronic illnesses. To analyze this complex system for rational design of drug delivery implants, we developed a mechanistic mathematical model to quantify the molecular events and processes. With a β-cyclodextrin hydrogel host matrix, defined release rates were obtained using a fluorescent model drug. The key processes were the complexation between the drug and cyclodextrin and diffusion of the drug in the hydrogel. Optimal estimates of the model parameters were obtained by minimizing the difference between model simulation and experimentally measured drug release kinetics. Model simulations could predict the drug release dynamics under a wide range of experimental conditions.

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Section: Introductionmentioning

confidence: 99%

Experimental Studies and Modeling of Drug Release from a Tunable Affinity-Based Drug Delivery Platform

Thatiparti

Saidel

et al. 2011

Ann Biomed Eng

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“…Various hydrogels have been developed as controlled drug release carriers using water-soluble, biodegradable polymeric materials (Gudeman & Peppas, 1995;Park, Choi, Kim, & Kim, 1998;Park, Song, Kim, & Kim, 1998;Wang, Turhan, & Gunasekaran, 2004;Wen & Stevenson, 1993) including synthetic or natural polymers.…”

Section: Introductionmentioning

confidence: 99%

Use of whey proteins for encapsulation and controlled delivery applications

Gunasekaran

Xiao

2007

Journal of Food Engineering

287

176

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“…This transition to expanded state is mediated by the osmotic pressure exerted by various stimuli responsible for controlling drug release from smart polymeric delivery systems . pH responsive polymers typically include also chitosan [144], albumin [145], gelatin [146], poly(acrylic acid) (PAAc)/chitosan IPN [147], poly(methacrylic acid-g-ethylene glycol) [P(MAA-g-EG)] [148,149], poly(ethylene imine) (PEI) [150], poly(N,Ndiakylamino ethylmethacrylates) (PDAAEMA), and poly(lysine) (PL) [151,152].…”

Section: Ph-responsive Polymersmentioning

confidence: 99%

Drug Delivery Systems: Smart Polymeric Materials

Cassano

Trombino

2014

Advanced Polymers in Medicine

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Over the last two decades the smart polymeric materials have involved the interest of the scientific community because they can be used in the design and formulation of dosage forms that respond, with a considerable variation of their properties, to changes in their environment. As result, these materials control the drug release into specific physiological compartments. Concerning on the environmental stimuli these include pH, temperature, light, chemicals, etc. The smart polymeric materials stimuli-responsive can be synthetics or naturals and have been used in the biotechnological, medicinal and engineering fields. The present chapter is aimed to focus the importance of this category of drug delivery systems and, in particular, it provides a summarizing overview of the range of smart polymeric materials and the drug delivery systems that exploit them.

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Preparation of thermally denatured albumin gel and its pH-sensitive swelling

Cited by 63 publications

References 13 publications

Experimental Studies and Modeling of Drug Release from a Tunable Affinity-Based Drug Delivery Platform

Experimental Studies and Modeling of Drug Release from a Tunable Affinity-Based Drug Delivery Platform

Use of whey proteins for encapsulation and controlled delivery applications

Drug Delivery Systems: Smart Polymeric Materials

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