Preparation of Theophylline-Loaded Calcium Alginate Gel Capsules and Evaluation of Their Drug Release Characteristics.

Tomida, Hisao; Nakamura, Chie; Yoshitomi, Hironori; Kiryu, Setsuo

doi:10.1248/cpb.41.2161

Cited by 19 publications

(7 citation statements)

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“…Alginate has been applied in the preparation of gel capsules. In one study, the compound theophylline was encapsulated and the drug release rate was significantly reduced compared to the matrix-type alginate gel beads (9). The release rate became lower as the coat thickness increased.…”

Section: Diffusion Systemsmentioning

confidence: 99%

Alginate in Drug Delivery Systems

Tønnesen

Karlsen

2002

Drug Development and Industrial Pharmacy

1,265

613

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Alginates are established among the most versatile biopolymers, used in a wide range of applications. The conventional use of alginate as an excipient in drug products generally depends on the thickening, gel-forming, and stabilizing properties. A need for prolonged and better control of drug administration has increased the demand for tailor-made polymers. Hydrocolloids like alginate can play a significant role in the design of a controlled-release product. At low pH hydration of alginic acid leads to the formation of a high-viscosity ''acid gel.'' Alginate is also easily gelled in the presence of a divalent cation as the calcium ion. Dried sodium alginate beads reswell, creating a diffusion barrier decreasing the migration of small molecules (e.g., drugs). The ability of alginate to form two types of gel dependent on pH, i.e., an acid gel and an ionotropic gel, gives the polymer unique properties compared to neutral macromolecules. The molecule can be tailor-made for a number of applications. So far more than 200 different alginate grades and a number of alginate salts are manufactured. The potential use of the various qualities as pharmaceutical excipients has not been evaluated fully, but alginate is likely to make an important contribution in the development of polymeric delivery systems. This natural polymer is adopted by Ph.Eur. It can be obtained in an ultrapure form suitable for implants. This review discusses the present use and future possibilities of alginate as a tool in drug formulation.

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Section: Diffusion Systemsmentioning

confidence: 99%

Alginate in Drug Delivery Systems

Tønnesen

Karlsen

2002

Drug Development and Industrial Pharmacy

1,265

613

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show abstract

“…Alginate gel structure is relatively stable at acidic pH, but it is easily swollen and disintegrated under mild alkali conditions [9]. Thus, alginate gel has been applied to produce an effective controlled release carrier [10][11][12][13] as forms of matrix, bead, and microcapsule [8,[14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Microencapsulation of α-tocopherol using sodium alginate and its controlled release properties

Yoo

Song

Chang

et al. 2006

International Journal of Biological Macromolecules

162

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“…O alginato de cálcio vem sendo amplamente estudado para recobrimento de partículas, tanto na área alimentícia quanto na farmacêutica. A ligação de alginato de sódio com cloreto de cálcio gera um gel rígido de alginato de cálcio, que não apresenta toxicidade (TOMIDA et al, 1993). A quitosana também vem se apresentado como um bom agente de recobrimento de partículas.…”

Section: Lista De Figurasunclassified

Estudo das alterações na microestrutura de partículas de amido de milho em processos de granulação

Hubinger¹

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Preparation of Theophylline-Loaded Calcium Alginate Gel Capsules and Evaluation of Their Drug Release Characteristics.

Cited by 19 publications

References 0 publications

Alginate in Drug Delivery Systems

Alginate in Drug Delivery Systems

Microencapsulation of α-tocopherol using sodium alginate and its controlled release properties

Estudo das alterações na microestrutura de partículas de amido de milho em processos de granulação

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