Preparation of the chitosan/poly(glutamic acid)/alginate polyelectrolyte complexing hydrogel and study on its drug releasing property

Chen, Yu; Yan, Xiaoting; Zhao, Jian; Feng, Huaiyu; Li, Puwang; Tong, Zongrui; Yang, Ziming; Li, Sidong; Yang, Jueying; Jin, Shaohua

doi:10.1016/j.carbpol.2018.02.065

Cited by 94 publications

(47 citation statements)

References 27 publications

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“…Furthermore, the deconvolution of the O 1s spectra of the samples shows two peaks with BEs of 529.8 and 531.5 eV (for raw membrane). These peaks can be assigned to O element in C_O and C\ \O, respectively [68]. After Se(VI) sorption, the peak area of C_O increases from 8.2% to 9.4% while the peak area of C\ \O decreases from 91.8% to 90.6%.…”

Section: −mentioning

confidence: 95%

Se(VI) sorption from aqueous solution using alginate/polyethylenimine membranes: Sorption performance and mechanism

Mo¹,

Vincent²,

Faur

et al. 2020

International Journal of Biological Macromolecules

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New high percolating alginate membranes are designed without using sophisticated drying methods: negatively charged alginate reacts with positively charged polyethylenimine (PEI), prior to be crosslinked with glutaraldehyde and air-dried. This is sufficient to obtain a highly macroporous structured membrane. Highly percolating properties of these new A-PEI membranes make the material applicable in natural drainage systems. The high density of amine groups in composite membranes explain their high affinity for anions in acidic solutions. FTIR, SEM-EDX and XPS analysis are used to explore the sorption mechanism. Se(VI) is sorbed through electrostatic attraction between positive amine groups and negative selenium anions; in a second step, bound Se(VI) is reduced by amine and hydroxyl groups in acidic conditions. A-PEI membranes are successfully used for recovering Se(VI) anions at pH 2. The maximum sorption capacity is close to 83 mg Se g −1 ; the sorption isotherm is described by the Sips and Langmuir equations. The membranes are poorly sensitive to flow rate in the range 15-50 mL min −1. The kinetic profiles are fitted by the pseudo-first order rate equation. Solute desorption is operated using NaOH solutions; the sorbent shows a remarkable stability in sorption and desorption properties for a minimum of 4 cycles.

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Section: −mentioning

confidence: 95%

Se(VI) sorption from aqueous solution using alginate/polyethylenimine membranes: Sorption performance and mechanism

Mo¹,

Vincent²,

Faur

et al. 2020

International Journal of Biological Macromolecules

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“…Recently, hydrogels made of natural polymers, such as alginate, collagen, chitosan (CHI), gelatin, and L-glutamic acid (LGA), have been used in numerous fields, especially as biomaterials [ 19 , 20 , 21 ]. Among these polymers, CHI and LGA have many reported applications in different fields, such as tissue engineering, regenerative medicine, and drug delivery [ 22 , 23 , 24 , 25 , 26 , 27 , 28 ]. Thus, CHI can be regarded as a favorable material for coating onto magnesium alloys due to its biocompatibility, low toxicity, immune-stimulatory activity, and biodegradability [ 24 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Mg-Zn-Ca Alloys for Hemostasis Clips for Vessel Ligation: In Vitro and In Vivo Studies of Their Degradation and Response

et al. 2020

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To control the degradation rate of magnesium (Mg) alloys, chitosan (CHI) and L-glutamic acid (LGA) were used as coatings on Mg-Zn-Ca alloys via dip coating. In this study, either two or seven CHI/LGA layers were applied as a coating on Mg-2.8Zn-0.8Ca alloy (ZX31) and Mg-2.8Zn-0.8Ca hemostasis clips (ZX31 clips). The morphologies, compositions, and surface roughness of the specimens were characterized via scanning electron microscopy, Fourier transform infrared spectroscopy, and surface measurement devices. The degradation rates and behavior of the specimens were evaluated by immersing them in simulated body fluids and by applying these ZX31 clips on rabbits’ uterine tubes for five weeks. The specimen with seven layers (ZX31(CHI/LGA)7) exhibited improved corrosion behavior when compared with ZX31 or ZX31(CHI/LGA)2, with a reduced degradation rate of the Mg alloy in a simulated body environment. In vivo experiments showed that ZX31 clips exhibited good biocompatibilities in each group but could not maintain the clamping function for five weeks. The weight loss of ZX31(CHI/LGA)7 was significantly lower than that of the other groups. Consequently, it was verified that CHI can be used as a protective layer on a magnesium alloy surface via in vitro and in vivo experiments.

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“…Upon the formation of ionic interactions, new bonds between the polymers are created and the proper spatial conformation is achieved, followed by the stabilization of the obtained PEC by establishing the hydrophobic bonds between polymer chains (8). During the PEC formation, polymers can form coacervates as a consequence of precipitation due to the strong interactions between oppositely charged polyions (5,9). Precipitation can be prevented by the addition of salts, e.g., sodium chloride.…”

Section: Introductionmentioning

confidence: 99%

Biocompatible non-covalent complexes of chitosan and different polymers: Characteristics and application in drug delivery

Ćirić¹,

Krajišnik²,

Čalija³

et al. 2020

Arhiv za farmaciju

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The formulation of biocompatible drug carriers based on cationic biopolymer chitosan and natural or synthetic polymers represents an important research interest. Therefore, this review aims to perceive their potential in drug delivery. The most investigated chitosan-based polymer blends are polyelectrolyte complexes (PECs) obtained by establishing ionic interactions with biocompatible polyanions as alginates, pectin, xanthan gum, carrageenan, carboxymethylcellulose, and collagen. Depending on the preparation conditions, PECs could be prepared in versatile forms including membranes/films, hydrogel beads, nanoparticles, and microparticles, to achieve controlled (e.g., extended, delayed, colon-specific and pH-dependent) drug delivery. PECs can encapsulate hydrophilic and lipophilic drug substances with different molecular weights. Drug encapsulation allows the preservation of their structure, activity, improvement in absorption efficiency, reduction in adverse effects and long-term stability in vitro and in vivo. The biocompatible structures as non-covalent chitosan-based complexes could be formed also by establishing hydrogen bonds, for example with poly(vinyl alcohol). The swelling of these complexes is not pH-dependent and encapsulated drug substances are often released by already known types of diffusion. Moreover, grafted chitosan derivatives (e.g., carboxymethyl chitosan, trimethyl chitosan, acrylated chitosan) are synthesized to improve water solubility at a wide pH range and enhance the encapsulation capacity of promising PEC-based drug carriers.

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Preparation of the chitosan/poly(glutamic acid)/alginate polyelectrolyte complexing hydrogel and study on its drug releasing property

Cited by 94 publications

References 27 publications

Se(VI) sorption from aqueous solution using alginate/polyethylenimine membranes: Sorption performance and mechanism

Se(VI) sorption from aqueous solution using alginate/polyethylenimine membranes: Sorption performance and mechanism

Mg-Zn-Ca Alloys for Hemostasis Clips for Vessel Ligation: In Vitro and In Vivo Studies of Their Degradation and Response

Biocompatible non-covalent complexes of chitosan and different polymers: Characteristics and application in drug delivery

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