Preparation of temperature-sensitive membranes by graft polymerization onto a porous membrane

Iwata, Hiroo; Oodate, Masaya; Uyama, Yoshikimi; Amemiya, Hiroshi; Ikada, Yoshito

doi:10.1016/s0376-7388(00)82330-3

Cited by 195 publications

(104 citation statements)

References 5 publications

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“…Although the temperature sensitive properties of the present NIPAAM-g-PVDF membranes for aqueous solutions are similar, to a certain extent, to those reported in the earlier work involving modified PVDF membranes from surface grafting, [18] the membranes obtained in this work can also be applied for regulating the permeability of certain organic solutions. Most important of all, the present work offers an alternative approach to membrane surface modification and functionalization.…”

Section: Discussionsupporting

confidence: 77%

Novel Poly(N‐isopropylacrylamide)‐graft‐poly(vinylidene fluoride) Copolymers for Temperature‐Sensitive Microfiltration Membranes

Ying¹,

Kang²,

Neoh³

et al. 2003

Macro Materials & Eng

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In the present work, we report on the synthesis and characterization of poly(vinylidene fluoride) (PVDF) with N‐isopropylacrylamide (NIPAAM) polymer side chains from molecular graft copolymerization in solution. The copolymer can be readily cast into temperature‐sensitive microfiltration (MF) membranes by the phase inversion technique. The copolymer approach to membrane fabrication allows a much better control of the physicochemical nature of the membrane pores through the variation in graft concentration, membrane casting temperature and concentration of the membrane casting solution. magnified image

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Section: Discussionsupporting

confidence: 77%

Novel Poly(N‐isopropylacrylamide)‐graft‐poly(vinylidene fluoride) Copolymers for Temperature‐Sensitive Microfiltration Membranes

Ying¹,

Kang²,

Neoh³

et al. 2003

Macro Materials & Eng

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“…The LCST of polymers is well known to be modulated by copolymerizing IPAAm with a hydrophobic or hydrophilic monomer [49][50][51][52]. Thus, to induce cell attachment/detachment at a lower temperature, IPAAm has been copolymerized with a hydrophobic monomer, n-butyl methacrylate (BMA), and grafted to TCPS by EB irradiation [53].…”

Section: Patterned Temperature-responsive Polymer Modified Surfacementioning

confidence: 99%

Temperature-Responsive Polymer Modified Surface for Cell Sheet Engineering

2012

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Abstract:In the past two decades, as a novel approach for tissue engineering, cell sheet engineering has been proposed by our laboratory. Poly(N-isopropylacrylamide) (PIPAAm), which is a well-known temperature-responsive polymer, has been grafted on tissue culture polystyrene (TCPS) surfaces through an electron beam irradiated polymerization. At 37 °C, where the PIPAAm modified surface is hydrophobic, cells can adhere, spread on the surface and grow to confluence. By decreasing temperature to 20 °C, since the surface turns to hydrophilic, cells can detach themselves from the surface spontaneously and form an intact cell sheet with extracellular matrix. For obtaining a temperature-induced cell attachment and detachment, it is necessary to immobilize an ultra thin PIPAAm layer on the TCPS surfaces. This review focuses on the characteristics of PIAPAm modified surfaces exhibiting these intelligent properties. In addition, PIPAAm modified surfaces giving a rapid cell-sheet recovery has been further developed on the basis of the characteristic of the PIPAAm surface. The designs of temperature-responsive polymer layer have provided an enormous potential to fabricate clinically applicable regenerative medicine.

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“…As the latter decreases, the hydrophobic forces outweigh the electrostatic one, and the gel show collapse at lower temperature. This is the normal behavior of temperature-sensitive polymers that show lower LCST for the incorporation of hydrophobic moieties [10]; the contrary is true for the incorporation of hydrophilic substituents, thus leading to a greater phase-transition temperature that vanishes at high charge density. From a practical point of view, the hydrogel AVa-2 may be a good candidate in drug delivery technologies because different external signals may trigger the release of the drug.…”

mentioning

confidence: 94%

Multiple Stimuli-Responsive Hydrogels for Metal-Based Drug Therapy

Casolaro

2012

Polymers

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A series of homopolymeric and copolymeric hydrogels containing the N-isopropylacrylamide and vinyl monomers with α-amino acid (L-valine and L-phenylalanine) residues have been synthesized and their swelling properties were evaluated under different external stimulations. The hydrogels, obtained with different cross-linking agents (EBA and PEG-DA), have shown unique properties such as biocompatibility in addition to the stimuli-responsive characters. These 'smart' hydrogels exhibit single or multiple stimuli-responsiveness which could be used in biomedical applications, including controlled drug delivery. This article focuses on recent developments dealing with the delivery of metal-based drug (cisplatin, lithium) from the stimuli-responsive hydrogels proposed as platforms for cancer and bipolar disorder therapies.

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Preparation of temperature-sensitive membranes by graft polymerization onto a porous membrane

Cited by 195 publications

References 5 publications

Novel Poly(N‐isopropylacrylamide)‐graft‐poly(vinylidene fluoride) Copolymers for Temperature‐Sensitive Microfiltration Membranes

Novel Poly(N‐isopropylacrylamide)‐graft‐poly(vinylidene fluoride) Copolymers for Temperature‐Sensitive Microfiltration Membranes

Temperature-Responsive Polymer Modified Surface for Cell Sheet Engineering

Multiple Stimuli-Responsive Hydrogels for Metal-Based Drug Therapy

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