Preparation of sulfur nanoparticles and their antibacterial activity and cytotoxic effect

Shankar, Shiv; Pangeni, Rudra; Park, Jin Woo; Rhim, Jong‐Whan

doi:10.1016/j.msec.2018.07.015

Cited by 94 publications

(70 citation statements)

References 32 publications

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“…This phenomenon has been reported in many previous studies [16,26]. With the particle size of less than 500 nm, oil/PAMAM G4.0 (average diameter around 40–120 nm) is considered as a sufficiently good material for the penetration of nanocarriers into fungal cells [22,23,24,25]. In addition, PAMAM G4.0 with large number of positively charged surface –NH 2 – groups facilitates the interaction and destruction of microbial negatively charged membrane.…”

Section: Resultssupporting

confidence: 60%

“…After the oil was associated with dendrimer, a significant increment in the diameter of obtained oil/PAMAM G4.0 (40–150 nm) was observed, indicating the successful combination of essential oil with PAMAM G4.0 structure. There are many studies reported that the particle size of less than 500 nm is sufficiently good for the penetration of nanocarriers into fungal cells [22,23,24,25]. As a result, G4.0 and oil/PAMAM G4.0 is suitable for associating with oil to fully interact with the fungus’s cell membrane as well as easily penetrates into the cell layer, thus destroying fungal cells.…”

Section: Resultsmentioning

confidence: 99%

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Origanum majorana L. Essential Oil-Associated Polymeric Nano Dendrimer for Antifungal Activity against Phytophthora infestans

Thanh¹,

Bui

Bạch

et al. 2019

Materials

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In this study, the introduction of Origanum majorana L. essential oil into a polyamidoamine (PAMAM) G4.0 dendrimer was performed for creation of a potential nanocide against Phytophthora infestans. The characteristics of marjoram oil and PAMAM G4.0 was analyzed using transmission electron spectroscopy (TEM), nuclear magnetic resonance spectroscopy (1H-NMR) and gas chromatography mass spectrometry (GC-MS). The success of combining marjoram oil with PAMAM G4.0 was evaluated by FT-IR, TGA analysis, and the antifungal activity of this system was also investigated. The results showed that the antifungal activity of oil/PAMAM G4.0 was high and significantly higher than only PAMAM G4.0 or marjoram essential oil. These results indicated that the nanocide oil/PAMAM G4.0 helped strengthen and prolong the antifungal properties of the oil.

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Section: Resultssupporting

confidence: 60%

Section: Resultsmentioning

confidence: 99%

Origanum majorana L. Essential Oil-Associated Polymeric Nano Dendrimer for Antifungal Activity against Phytophthora infestans

Thanh¹,

Bui

Bạch

et al. 2019

Materials

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“…41 It was also demonstrated that the degree of antibacterial activity is dependent on the type of sulfur nanoparticles (SNPs). In the study, 20…”

Section: X-ray Photoelectron Spectroscopymentioning

confidence: 95%

“…SPs were synthesized according to the method described in the work,20 with slight modifications. A mixture of sodium thiosulfate and chitosan was prepared by combining 50 ml of 0.1 M Na 2 S 2 O 3 with 5 ml of (i) 0.05%, (ii) 0.1% or (iii) 0.2% chitosan solution (1% v/v acetic acid solution).…”

mentioning

confidence: 99%

Chitosan‐capped sulfur microparticles grafted on UV‐treated PET surface

Lupínková¹,

Kaimlová

Kormunda³

et al. 2020

Surface & Interface Analysis

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Antimicrobial materials with immobilized particles are of considerable interest. Sulfur, as one of the abundant elements on earth, is cheap and environmentally friendly; therefore, sulfur particles (SPs) can be used as an effective, nontoxic and low‐cost alternative to metal particles. SPs were prepared by precipitation method using sodium thiosulfate and hydrochloric acid in the presence of chitosan as a stabilizer. Further, SPs were grafted on polyethylene terephthalate (PET) foil activated by ultraviolet radiation. The changes in surface properties of modified foils were characterized by contact angle measurement, electrokinetic analysis and X‐ray photoelectron spectroscopy (XPS). The contact angle decreased on the UV‐treated sample, owing to the formation of oxidized groups. The presence of nitrogen and sulfur on the polymer surface, revealed by XPS, showed that chitosan‐capped SPs were bound to this surface. The surface morphology of samples and particle sizes were examined by scanning electron microscopy. The size of SPs increased after grafting on surface to a few micrometres. The antibacterial activity of the PET samples was tested against Staphylococcus epidermidis and Escherichia coli bacteria strains. UV‐treated samples grafted with one of the tested chitosan‐capped SPs demonstrated antibacterial effect against both of the bacteria strains. This new nanocomposite has potential to be used in medical applications as an antibacterial agent or in food processing as an antimicrobial food packaging material. Food spoilage caused by microorganisms such as E. coli during distribution and storage has a major impact on food quality and shelf life.

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“…The percentage cell viability at each concentration was calculated using linear regression analysis. Accordingly, half maximal inhibitory concentration (IC 50 ) value of each formula (The dose of the formulation that inhibited 50% cell viability) was determined 34,35…”

Section: Methodsmentioning

confidence: 99%

<p>A comparative study: the prospective influence of nanovectors in leveraging the chemopreventive potential of COX-2 inhibitors against skin cancer</p>

Aasy

Ragab

Sallam

et al. 2019

IJN

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IntroductionThis study was conducted to elucidate the chemopreventive potential, cytotoxic, and suppression of cellular metastatic activity of etodolac (ETD)-loaded nanocarriers.MethodsTo esteem the effect of charge and composition of the nanovectors on their performance, four types of vectors namely, negative lipid nanovesicles; phosalosomes (N-Phsoms), positive phosalosomes (P-Phsoms), nanostructured lipid carriers (NLCs) and polymeric alginate polymer (AlgNPs) were prepared and compared. ETD was used as a model cyclo-oxygenase-2 (COX-2) inhibitor to evaluate the potency of these nanovectors to increase ETD permeation and retention through human skin and cytotoxicity against squamous cell carcinoma cell line (SCC). Moreover, the chemopreventive activity of ETD nanovector on mice skin cancer model was evaluated.ResultsAmong the utilized nanovectors, ETD-loaded N-Phsoms depicted spherical vesicles with the smallest particle size (202.96±2.37 nm) and a high zeta potential of −24.8±4.16 mV. N-Phsoms exhibited 1.5, and 3.6 folds increase in the ETD amount deposited in stratum corneum, epidermis and dermis. Moreover, cytotoxicity studies revealed a significant cytotoxic potential of such nanovector with IC50=181.76 compared to free ETD (IC50=982.75), correlated to enhanced cellular internalization. Its efficacy extended to a reduction in the relative tumor weight with 1.70 and 1.51-fold compared to positive control and free ETD, that manifested by a 1.72-fold reduction in both COX-2 and proliferating cell nuclear antigen mRNA (PCNA-mRNA) levels and 2.63-fold elevation in caspase-3 level in skin tumors relative to the positive control group with no hepato-and nephrotoxicity.ConclusionEncapsulation of ETD in nanovector enhances its in-vitro and in-vivo anti-tumor activity and opens the door for encapsulation of more relevant drugs.

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Preparation of sulfur nanoparticles and their antibacterial activity and cytotoxic effect

Cited by 94 publications

References 32 publications

Origanum majorana L. Essential Oil-Associated Polymeric Nano Dendrimer for Antifungal Activity against Phytophthora infestans

Origanum majorana L. Essential Oil-Associated Polymeric Nano Dendrimer for Antifungal Activity against Phytophthora infestans

Chitosan‐capped sulfur microparticles grafted on UV‐treated PET surface

<p>A comparative study: the prospective influence of nanovectors in leveraging the chemopreventive potential of COX-2 inhibitors against skin cancer</p>

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