Preparation of sterol-imprinted polymers with the use of 2-(methacryloyloxy)ethyl phosphate

Kugimiya, Akimitsu; Kuwada, Yasuyuki; Takeuchi, Toshio

doi:10.1016/s0021-9673(01)01384-x

Cited by 32 publications

(22 citation statements)

References 12 publications

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“…376 Other acid monomers used with varying success are 4-vinylbenzoic acid, 377 acrylic acid, [378][379][380] 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPSA), 381,382 (2-trifluoromethyl)acrylic acid, [383][384][385] itaconic acid 386 and 2-(methacryloyloxy)ethyl phosphate. 387 Amongst the basic monomers, 4-vinylpyridine is the most commonly employed, [388][389][390] but other basic monomers such as N,N-diethylaminoethyl methacrylate, 391,392 aminostyrene 393,394 and vinylimidazole 388,395 have also been used. Among the neutral monomers, acrylamide, [396][397][398][399][400][401] vinyl pyrrolidone [402][403][404][405][406][407][408][409] and 2-hydroxyethyl methacrylate (HEMA) [410][411][412] have all been used.…”

Section: 329mentioning

confidence: 99%

Molecular imprinting science and technology: a survey of the literature for the years up to and including 2003

Andersson²,

et al. 2006

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Over 1450 references to original papers, reviews and monographs have herein been collected to document the development of molecular imprinting science and technology from the serendipitous discovery of Polyakov in 1931 to recent attempts to implement and understand the principles underlying the technique and its use in a range of application areas. In the presentation of the assembled references, a section presenting reviews and monographs covering the area is followed by papers dealing with fundamental aspects of molecular imprinting and the development of novel polymer formats. Thereafter, literature describing attempts to apply these polymeric materials to a range of application areas is presented.

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Section: 329mentioning

confidence: 99%

Molecular imprinting science and technology: a survey of the literature for the years up to and including 2003

Andersson²,

et al. 2006

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“…In fact, polymers containing acrylamide (AM) or 4-vinylpyridine (4VP) show the best binding properties, while acrylic acid results in one of the last efficient functional monomers and the polymer prepared with methacrylic acid (MAA) -which is one of the most commonly used functional monomers and is reported in literature for several successful corticosteroid imprintings (Ramström et al, 1996;Ramström et al, 1998;Baggiani et al, 2000) -shows a less marked binding ability and is comparable with many other functional polymers considered in this study. Surprisingly, ethyleneglycole methacrylate phosphate (EMP) and 2-hydroxyethyl methacrylate (HEMA) -two monomers described as very efficient in molecular imprinting of steroids (Sreenivasan, 1998;Kugimiya et al, 2001) -did not behave better than methacrylic acid, while tertiary amines (DEAEM and DMAEM) and N-vinylpyrrolidone (NVP) do not show any binding difference between imprinted and non-imprinted polymers.…”

Section: -Selection Of the Best Binding Polymermentioning

confidence: 99%

Molecularly imprinted polymers for corticosteroids: Analysis of binding selectivity

Baggiani

Baravalle

Giovannoli

et al. 2010

Biosensors and Bioelectronics

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In this work we prepared a library of cortisol-imprinted polymers via a sequential approach by combining 10 different functional monomers, 7 cross-linkers and 5 porogen solvents. The best combinations of functional monomers, cross-linkers and porogen solvents in terms of cortisol binding were used to prepare three imprinted polymers--polyacrylamide-co-ethylene dimethacrylate (porogen: chloroform), poly-4-vinylpyridine-co-ethylene dimethacrylate (porogen: chloroform) and polyacrylamide-co-ethylene dimethacrylate (porogen: acetonitrile)--whose selectivity towards 10 synthetic corticosteroids and 4 natural steroidal hormones was tested. The experimental results obtained show how different combinations of functional monomers, cross-linkers and porogen solvents produce cortisol-imprinted polymers with very different selectivity patterns, and that a careful optimization of the pre-polymerization mixtures makes it possible to increase the number of target steroids recognized by the resulting imprinted polymer. Moreover, through the use of a Free-Wilson analysis of the binding selectivity, it has been possible to obtain insights on the steroidal structural motifs able to increase or decrease the molecular recognition of corticosteroids by the imprinted polymers.

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“…In basic studies Takeuchi et al developed several kinds of template for recognition of atrazine [59], biotin derivatives [60], metalloporphyrins [61], sterols [62], or indoleacetic acid [63], and for formation of receptors [64], fluorescent-shift receptors [65], or templates having disulfide groups [66,67]. Study of polymer-recognizing biomolecules and anti-idiotypic approach is currently being performed by Mosbach et al to develop the next generation of MIPs [68,69].…”

Section: Molecularly Imprinting Polymers (Mips)mentioning

confidence: 99%

Current research activity in biosensors

Nakamura

Karube

2003

Analytical and Bioanalytical Chemistry

255

129

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Biosensors consist of a molecular recognition element and a transducer. Since the first biosensor was developed by Updike and Hicks many biosensors and their associated techniques have been studied and developed. In this review current research activity on the fundamentals and applications of biosensors is summarized. In discussion of the former, molecular recognition elements, techniques and tools for biosensor construction, and basic biosensor devices are introduced. Coverage of the latter includes description of biosensors for environmental, food, and clinical fields. Chemical sensors developed in our laboratory for environmental monitoring are also described. This review mainly summarizes work performed by our group and by our colleagues, and refers to the main review articles summarizing each field of biosensor research in recent years.

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Preparation of sterol-imprinted polymers with the use of 2-(methacryloyloxy)ethyl phosphate

Cited by 32 publications

References 12 publications

Molecular imprinting science and technology: a survey of the literature for the years up to and including 2003

Molecular imprinting science and technology: a survey of the literature for the years up to and including 2003

Molecularly imprinted polymers for corticosteroids: Analysis of binding selectivity

Current research activity in biosensors

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