Preparation of stereocomplex and pseudo-polyrotaxane with various cyclodextrins as wheel components using triblock copolymer of poly(ethylene glycol) and polylactide

Jaeyeong, Choi; Ajiro, Hiroharu

doi:10.1039/d2sm01124g

Cited by 9 publications

(6 citation statements)

References 69 publications

(89 reference statements)

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“…Fortunately, our investigations confirmed that the intensity of the PLA interaction did not exceed that of the host-guest interaction. [36,53] With respect to Relationships (3) and ( 4), we explored these aspects in the current study. As alluded to in Relationship (2), based on our indirect expectations, if the SC formation exhibited greater strength than the host-guest interaction, it would impede the formation of the PPRX architecture.…”

Section: Resultsmentioning

confidence: 99%

“…The SC formation was achieved through the mixing of PPRXs composed of block copolymers (BCPs) with CDs, resulting in relatively stronger axle–axle interactions between their PLLA and PDLA segments (PLLA…PDLA) when compared to interactions between homopolymers, such as PLLA segments and PLLA segments (PLLA…PLLA). Subsequently, our investigations focused on examining how variations in the ring component could influence the architecture of PPRX and the formation of SC, utilizing α‐CD, β‐CD, and γ‐CD [ 53 ] (Figure 1b). It became evident that alterations in the ring components had a discernible impact on axle‐axle interactions.…”

Section: Introductionmentioning

confidence: 99%

“…Herein, we employed the same components for rotaxane architecture as in prior research, selecting the axle component, which consisted of triblock copolymers of PEG and PLA, and the ring component, comprising 𝛼-, 𝛽-, and 𝛾-CDs. [36,53]…”

Section: Introductionmentioning

confidence: 99%

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Proposal of Pseudo‐Capping Effects by Polymer–Polymer Interaction through Preparation of Stereocomplex Pseudo‐Polyrotaxane with Cyclodextrin and PEG‐PLA Triblock Copolymers

Choi,

Ajiro

2023

Macro Chemistry & Physics

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ABA types triblock copolymers, specifically poly(L‐lactide)‐co‐poly(ethylene glycol)‐co‐poly(L‐lactide) (PLLA‐PEG‐PLLA) and poly(D‐lactide)‐co‐poly(ethylene glycol)‐co‐poly(D‐lactide) (PDLA‐PEG‐PDLA), are employed for stereocomplexes (SCs) formation. These SCs are subsequently utilized as axles, in conjunction with various cyclodextrins (CDs) as ring moieties to create pseudo‐polyrotaxane (PPRX). The authors referred to this new construct as “SC PPRX”, to distinguish it from the earlier study, denoted as “PPRX SC”, which primarily focuses on SC within the PPRX. When attempting to form PPRXs in aqueous solutions, the authors encountered challenges related to the inclusion of CDs due to the robust presence of the SC structure. However, by using mixed solvents, such as water/acetone (10/1, v/v), a partial relaxation of the SC structure is observed. This allows for the successful inclusion of CDs, thereby facilitating the PPRX formation. These observations highlight the significance of axle–axle interaction, which, in this case, prevailed over axle–ring interactions in determining the outcome of the formation process. The authors propose the term, ‘SC pseudo‐capping effect’ to describe this unique phenomenon, underscoring the role of interactions among polymer chains, including polymer–polymer and axle–axle interactions, in shaping the architecture of rotaxanes. This study thus unveils a novel dimension of polymer‐polymer interactions within the realm of rotaxane.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Proposal of Pseudo‐Capping Effects by Polymer–Polymer Interaction through Preparation of Stereocomplex Pseudo‐Polyrotaxane with Cyclodextrin and PEG‐PLA Triblock Copolymers

Choi,

Ajiro

2023

Macro Chemistry & Physics

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“…Consequently, variable CyDs complexes have played important role(s) in drug delivery systems, e.g. to increase solubility, to enhance transdermal effect, to realize controlled release, to construct self-assemble structure, and to introduce stimulus responsive block [32][33][34]. Modern drug delivery systems use CyDs as ideal supramolecular hosts for the preparation of carriers in the form of micelles, vesicles, hydrogels, and metal-organic frameworks [35][36][37][38].…”

Section: Physicochemical Characteristics Alteration Of the Drugsmentioning

confidence: 99%

The Role of Cyclodextrin in the Construction of Nanoplatforms: From Structure, Function and Application Perspectives

Chen¹,

Zheng²,

Tian³

et al. 2023

Preprint

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Drug delivery systems consist of cyclodextrins (CyDs) have kept constant attention for good compatibility, negligible toxicity, and improved pharmacokinetics of drugs. The unique hollow structure has endowed a lot of functions, such as inclusion of guest molecules, functional modification of active hydroxyl groups, and noncovalent interactions. Besides, the polyhydroxy structure has further extended the functions of CyDs by inter/intramolecular interactions and chemical modification. Furthermore, the versatile functions of the complex contribute to physicochemical characteristics alteration of the drugs, therapeutic talent, stimulus-responsive switch, self-assemble capability, and fiber formation. This review attempts to list the recent progress of CyDs and discuss their roles in the drug delivery system. Future perspectives of the construction of CyD-based drug delivery systems are also discussed at the end of this review, which may be the possible directions for the construction of more rational and cost-effective delivery vehicles.

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“…The included guest molecules ranged from small molecules, ions, and proteins to polymers with certain shape and size requirements [ 30 ]. Consequently, variable CyDs complexes have played an important role(s) in drug delivery systems, e.g., increase solubility, enhance the transdermal effect, realize controlled release, construct the self-assembly structure, and introduce a stimulus-responsive block [ 31 , 32 , 33 ]. Modern drug delivery systems use CyDs as ideal supramolecular hosts for the preparation of carriers in the form of micelles, vesicles, hydrogels, and metal-organic frameworks [ 34 , 35 , 36 , 37 ].…”

Section: Applicationmentioning

confidence: 99%

The Role of Cyclodextrin in the Construction of Nanoplatforms: From Structure, Function and Application Perspectives

et al. 2023

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Cyclodextrins (CyDs) in nano drug delivery systems have received much attention in pursuit of good compatibility, negligible toxicity, and improved pharmacokinetics of drugs. Their unique internal cavity has widened the application of CyDs in drug delivery based on its advantages. Besides this, the polyhydroxy structure has further extended the functions of CyDs by inter- and intramolecular interactions and chemical modification. Furthermore, the versatile functions of the complex contribute to alteration of the physicochemical characteristics of the drugs, significant therapeutic promise, a stimulus-responsive switch, a self-assembly capability, and fiber formation. This review attempts to list recent interesting strategies regarding CyDs and discusses their roles in nanoplatforms, and may act as a guideline for developing novel nanoplatforms. Future perspectives on the construction of CyD-based nanoplatforms are also discussed at the end of this review, which may provide possible direction for the construction of more rational and cost-effective delivery vehicles.

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Preparation of stereocomplex and pseudo-polyrotaxane with various cyclodextrins as wheel components using triblock copolymer of poly(ethylene glycol) and polylactide

Abstract: The ABA-types triblock-copolymers (BCPs) of polylactide (PLA) and poly(ethylene glycol) (PEG) were synthesized as axle components for rotaxane formation. It is known that -cyclodextrin (CD) exists near the PEG moiety...

Cited by 9 publications

References 69 publications

Proposal of Pseudo‐Capping Effects by Polymer–Polymer Interaction through Preparation of Stereocomplex Pseudo‐Polyrotaxane with Cyclodextrin and PEG‐PLA Triblock Copolymers

Proposal of Pseudo‐Capping Effects by Polymer–Polymer Interaction through Preparation of Stereocomplex Pseudo‐Polyrotaxane with Cyclodextrin and PEG‐PLA Triblock Copolymers

The Role of Cyclodextrin in the Construction of Nanoplatforms: From Structure, Function and Application Perspectives

The Role of Cyclodextrin in the Construction of Nanoplatforms: From Structure, Function and Application Perspectives

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