Preparation of starch-based nanoparticles through high-pressure homogenization and miniemulsion cross-linking: Influence of various process parameters on particle size and stability

Shi, Aimin; Liu, Dong; Wang, Lijun; Li, Bing-zheng; Adhikari, Benu

doi:10.1016/j.carbpol.2010.10.011

Cited by 178 publications

(73 citation statements)

References 28 publications

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“…The advantages of the polymerization in the emulsion include: (i) quick polymerization, (ii) products with a high molecular weight [13], and (iii) well-defined stages and simple A c c e p t e d M a n u s c r i p t preparation. Thus, the polymerization in emulsion is an attractive approach to produce microparticles from hydrophilic natural materials [15].…”

Section: Introductionmentioning

confidence: 99%

Drug release mechanisms of chemically cross-linked albumin microparticles: Effect of the matrix erosion

Sitta

Guilherme

Silva

et al. 2014

Colloids and Surfaces B: Biointerfaces

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A c c e p t e d M a n u s c r i p t Page 4 of 25 A c c e p t e d M a n u s c r i p tsphericity. In such a case, BSA played a role as a surface active agent, replacing PVA. For longer stirring times, BSA was unable to act as an emulsifier.These microparticles showed an uncommon release profile, consisting of a two-step release mechanism, at the pH range studied. Considering that a two-step release mechanism is occurring, the experimental data were adjusted by applying modified power law and Weibull equations in order to describe release mechanism n and release rate constant k, respectively. Each one of the release stages was related to a specific value of n and k. The second stage was driven by a super case II transport mechanism, as a result of diffusion, macromolecular relaxation, and erosion. A third model, described by Hixson-Crowell, confirmed the erosion mechanism.Vit-B 12 diffusion kinetics in aqueous solutions (i.e., without the microparticles) follows a one-step process, being k dependent on the pH, confirming that the two-step release mechanism is a characteristic profile of the developed microparticles. The microparticles released only 2.70% of their initial drug load at pH 2, and 58.53% at pH 10.

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Section: Introductionmentioning

confidence: 99%

Drug release mechanisms of chemically cross-linked albumin microparticles: Effect of the matrix erosion

Sitta

Guilherme

Silva

et al. 2014

Colloids and Surfaces B: Biointerfaces

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“…Although there are various applications for native starch, its industrial usage is limited due to the some unfavorable characteristics such as poor solubility in cold water, tendency to retrograde and high viscosity once it is gelatinized (Shi et al 2011). Therefore, considerable effort has been focused on production of starch derivatives or modified products in order to broaden the application range of this biopolymer.…”

Section: Introductionmentioning

confidence: 99%

Preparation of cold water-soluble potato starch and its characterization

2013

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Alcoholic-alkaline treatment of starch results in granular cold water-soluble starch. The nature of structural alterations occurred in starch due to the treatment is however relatively vague. Potato starch was treated at various alcoholicalkali conditions and subjected to light microscopy, Fourier transform infrared (FTIR) spectroscopy and X-ray diffractometry. Alcoholic-alkaline treatment increased the solubility of starch in a temperature-dependant manner. The treated starch suspension was also more turbid than that of native counterpart at all concentrations, due probably to either the presence of higher number of water-soluble granules or leaching of amylose during alkalization. Alcoholic-alkali treating of starch did not disintegrate the granular assembly; albeit, decreased the crystalinity. Both native and treated starches showed the Btype pattern in X-ray diffractometry. FTIR spectroscopy revealed that characteristic peaks of hydroxyl groups were of low transmittance in spectrum of treated starch compared with that of native counterpart implying in participation of hydroxyl groups in interactions with modifying agents.

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“…Both CBs and nCBs were mostly spherical in shape. nCBs showed some degree of aggregation mainly due to strong van der Waals force and electrostatic attraction between cellulose molecules [23,45]. Most notably, the BET specific surface area of nCBs was substantially higher at 214 m 2 /g as compared to that of CBs at 127 m 2 /g (Figure 4(d)), indicating that the overall surface area of cellulose beads would increase substantially with decrease in their mean diameters.…”

Section: Characterization Of Cellulosementioning

confidence: 97%

“…The W/O microemulsion has been extensively used in various fields such as biomaterials synthesis and chemical engineering, with the surfactant monolayer providing stabilization by prohibiting direct contacts between water and oil, as well as by reducing the interfacial tension between the two immiscible 2 International Journal of Polymer Science phases. Effective dispersion of the aqueous phase in the oil phase leads to the formation of uniform microemulsion droplets which, in turn, help to maintain the shape and size of particles formed [20,23]. On the other hand, the nanoprecipitation (or solvent displacement) process could be used for the fabrication of cellulose particles of desirable particle size distributions via manipulating the synthesis parameters [24].…”

Section: Introductionmentioning

confidence: 99%

Optimizing Delivery Characteristics of Curcumin as a Model Drug via Tailoring Mean Diameter Ranges of Cellulose Beads

Voon

Pang

Chin

2017

International Journal of Polymer Science

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Spherical cellulose beads with tailored mean diameter between micrometer (20-80 m) and nanometer (40-200 nm) ranges were fabricated from regenerated cellulose of paper wastes via water-in-oil (W/O) microemulsion and nanoprecipitation processes, respectively. The mean diameter ranges of cellulose beads were precisely controlled via modulating fabrication parameters such as stirring speed, surfactant concentration, cellulose concentration, and reaction temperature. By tailoring their mean diameter ranges and using curcumin as a model drug, cellulose beads with enhanced loading capacities and optimized release kinetic profiles of curcumin were fabricated.

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Preparation of starch-based nanoparticles through high-pressure homogenization and miniemulsion cross-linking: Influence of various process parameters on particle size and stability

Cited by 178 publications

References 28 publications

Drug release mechanisms of chemically cross-linked albumin microparticles: Effect of the matrix erosion

Drug release mechanisms of chemically cross-linked albumin microparticles: Effect of the matrix erosion

Preparation of cold water-soluble potato starch and its characterization

Optimizing Delivery Characteristics of Curcumin as a Model Drug via Tailoring Mean Diameter Ranges of Cellulose Beads

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