Preparation of Some Imidazole Derivatives of 1,4-Naphthoquinone

Hoover, John R. E.; Day, Allan R.

doi:10.1021/ja01645a028

Cited by 61 publications

(41 citation statements)

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“…The imidazole derivative obtained from the reaction of benzyl derivative and hexamethylenetetramine in the presence of glacial acetic acid [13]. In a round flask (250 mL) was added 50 mL of glacial acetic acid to a mixture of benzyl derivative (2.90 gm, 0.01 mol), hexamethylenetetramine (0.256 gm, 0.005 mol) and ammonium acetate (6.0 gm, 0.23 mol).…”

Section: Preparation Of Derivative Imidazolementioning

confidence: 99%

Preparation and Biological Activities of New Heterocyclic Azo Ligand and Some of Its Chelate Complexes

Al-Muhanaa¹,

Al-Khafagy²

2018

Nano BioMed ENG

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New azo ligand, 2[(Aminoantipyren) azo]-4,5-bis(4-Methoxyphenyl)-H imidazole, (AAMPI) was prepared through coupling reaction of 4-amino antipyrine with 4,5-bis (4-methoxyphenyl) imidazole. Then, complexation of ligand with ions Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II) were prepared to yield six complexes. The optimal conditions were studied for all complexes in the mole ratio between metal:ligand (M:L) as of 1:2 in the general formula [M(L) 2 ]Cl 2 ·H 2 O. Present results found the azo ligand was tridentate. The structures of ligand with complexes were identified by ultravioletvisible spectroscopy (UV-Vis), Fourier-transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance ( 1 HNMR), carbon-13 nuclear magnetic resonance ( 13 CNMR), mass spectrometry, elemental analysis (CHN), magnetic susceptibility and molar conductance. All the complexes exhibit octahedral geometry around the metal center. The antibacterial activities of synthesized compound were tested against the gram-negative, gram-positive bacteria and fungus. The results showed that the metal complexes exhibited antibacterial and antifungal activities compared with free ligand.

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Section: Preparation Of Derivative Imidazolementioning

confidence: 99%

Preparation and Biological Activities of New Heterocyclic Azo Ligand and Some of Its Chelate Complexes

Al-Muhanaa¹,

Al-Khafagy²

2018

Nano BioMed ENG

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“…Quinones form an important class of toxic metabolites and paradoxically can be either mutagenic and, therefore, are potentially carcinogenic, or effective anticancer agents [9]. Some quinones possibly play roles in the cellular defence since they effectively inhibit growth of bacteria, fungi and/or parasites [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, Single Crystal Structural Studies, Antibacterial Activity and DFT Investigations of 2-Chloro-5-Ethoxy-3,6-Bis(Methylamino)-1,4-Benzoquinone

RK¹,

M²,

M³

2015

Pharm Anal Acta

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A new compound 2-chloro-5-ethoxy-3,6-bis(methylamino)-1,4-benzoquinone (cemb) has been synthesized and characterized by various physicochemical techniques. The compound crystallizes in the triclinic system with the space group P-1 and contains extended hydrogen bonding interaction providing supramolecular architecture. The compound contains CH•••π and oxygen•••π interaction which stabilizes the crystal structure and is also responsible for the semiconducting behavior. The DFT calculations in the gaseous phase of cemb with B3LYP hybrid functional show good correlation with experimental results (single crystal XRD data) and are used to predict the molecular properties. Excluding the side ethyl group, the structure possesses C s symmetry. The ring breathing mode of vibration is found to have frequency (551 cm -1 ) which is much lower as compared to the corresponding mode of benzene (991 cm -1 ). The bioefficacy of the compound has been examined against the growth of bacteria in vitro to evaluate antimicrobial potential. The pphotoluminescence properties indicate that the compound has characteristic fluorescence emissions. The HOMO and LUMO energy gap reveals that the energy gap reflects the chemical activity of the molecule.

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“…For these reasons, quinones have a wide range of biological activities, such as their capacity to act as decoupling agents of oxidative phosphorylation [6]; intercalating agents of the DNA double helix [7]; bioreductive alkylating agents of biomolecules [8]; and promoters, under aerobic conditions, of reactive oxygen radical formation through a redox cycle [9]. In addition, compounds containing a quinone group are efficient in inhibiting the growth of bacteria [10], fungi [11,12] and, parasites [6]. This implies that the redox chemistry of quinones is closely related to their biological activities, which themselves are directly affected by acid-basic properties of quinone, semiquinone and hydroquinone species.…”

Section: Introductionmentioning

confidence: 99%

Correlation of voltammetric behavior of α-hydroxy and α-methoxy quinones with the change of acidity level in acetonitrile

Bautista-Martínez

González

Aguilar-Martı́nez

2004

Journal of Electroanalytical Chemistry

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Preparation of Some Imidazole Derivatives of 1,4-Naphthoquinone

Cited by 61 publications

References 0 publications

Preparation and Biological Activities of New Heterocyclic Azo Ligand and Some of Its Chelate Complexes

Preparation and Biological Activities of New Heterocyclic Azo Ligand and Some of Its Chelate Complexes

Synthesis, Characterization, Single Crystal Structural Studies, Antibacterial Activity and DFT Investigations of 2-Chloro-5-Ethoxy-3,6-Bis(Methylamino)-1,4-Benzoquinone

Correlation of voltammetric behavior of α-hydroxy and α-methoxy quinones with the change of acidity level in acetonitrile

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