Preparation of solid dispersion of rutin by spay drying

Abstract

The poor solubility of rutin leads to poor bioavailability. The present study is aimed to increase the solubility and bioavailability of rutin using solid dispersion technique. The solid dispersions of rutin were prepared by spray-dried method using β-CD, HPMC E6, HPMC E15, PVP K30, SLS, poloxamer 188 and Tween 80 as carriers. The interaction of rutin with the carriers was evaluated by using methods such as dissolved measurement, Fourier-transformation infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and X-ray diffraction (XRD). The optimization of formulation was carried out by using Central Composite Face design. Independent variables include PVP K30/rutin ratio, Tween 80/rutin ratio, inlet air temperature, and feed flow rate. Dependent variables are the dissolution and product yield. The optimized preparation conditions for rutin solid dispersions were obtained as PVP K30: rutin at a ratio of 5.77, Tween 80: rutin at a ratio of 0.14, inlet temperature of 110.05, flow rate of 1370.9 ml per hour. The results of this study indicate that the solid dispersion of rutin increases significantly the dissolution of rutin in comparison with rutin. The results of the DSC and XRD studies prove the state transition of rutin from crystalline to amorphous.
 Keywords
 Rutin, solid dispersion, spray drying, PVP K30, dissolution.
 References
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Rutin Cocrystals with Improved Solubility, Bioavailability, and Bioactivities

“…However, the low solubility in water (about 125 μg/mL) and low oral bioavailability (4.9% in Sprague–Dawley rats) of rutin limited its application. , Various systems including nanocrystals, solid dispersion, self-double-emulsifying delivery system (SDEDS), and solid lipid nanoparticles have been used for improving rutin solubility. Mauludin et al prepared rutin nanocrystals by lyophilization.…”