Preparation of single chain nanoparticles via photoinduced radical coupling process

Dashan, Irem; Balta, Demet Karaca; Temel, Binnur Aydogan; Temel, Gokhan

doi:10.1016/j.eurpolymj.2019.01.054

Cited by 16 publications

(18 citation statements)

References 55 publications

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“…Although the primary focus of research in our laboratory has traditionally been ROMP, we were interested in designing a general process that could be applied toward the functionalization of other polymers as well. Of particular interest was the modification of poly(styrene‐ co ‐vinylbenzyl chloride) sidechains, which has been carried out using a variety of nucleophiles, including sulfur‐based species . In this vein, we were curious as to whether or not reactions similar to the thio‐bromo click reactions described above could be used to modify the benzyl‐chloride‐containing copolymer 10 .…”

Section: Resultsmentioning

confidence: 99%

Post‐Polymerization Thiol Substitutions Facilitated by Mechanochemistry

Ashlin

Hobbs

2019

Macro Chemistry & Physics

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The use of mechanical force to facilitate post‐polymerization, solvent‐free thiol substitution reactions is described. These reactions are amenable to halogen‐containing materials prepared using ring opening metathesis polymerization and free radical polymerization reactions. Reactions of these polymers with various thiols can be carried out in a ball mill and are complete in a matter of minutes. Further, 1H NMR and GPC analysis show no significant decomposition of the polymer chain.

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Section: Resultsmentioning

confidence: 99%

Post‐Polymerization Thiol Substitutions Facilitated by Mechanochemistry

Ashlin

Hobbs

2019

Macro Chemistry & Physics

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“…In this case, the parent polymer is slowly added to a solution containing the bivalent crosslinker. Successful examples of the continuous addition approach in external crosslinker mediated SCNP folding include reactions of isocyanates with amine crosslinkers to form urea linkages, metal complexation of M 2 4+ paddlewheel folding motifs, photochemical crosslinking and Thiol‐Michael additions . The continuous addition procedure, thus, presents a versatile route for both external and internal crosslinker mediated folding, to suppress the parasitic interchain reaction and achieve an efficient scale up of SCNP synthesis.…”

Section: Synthesis: Tackling the Scalabilitymentioning

confidence: 99%

Macromolecular Superstructures: A Future Beyond Single Chain Nanoparticles

Frisch

Tuten

Barner‐Kowollik

2020

Israel Journal of Chemistry

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Over the last 100 years polymer chemistry has flourished in all areas and enabled control over synthetic polymer architectures – including chain lengths, dispersity and monomer sequences. Compared to the architectures of biomacromolecules, these scientific achievements mainly took place on the level of primary structures. The plethora of functions carried out by proteins in nature, however, does not only result from their primary structure, but from its folding into perfectly defined 3D structures. Striving towards a similar architectural control and function in synthetic polymers, the field of single chain nanoparticles (SCNPs) emerged. In this review, we analyze the state of the art and identify what is currently standing between polymer chemistry and perfectly controlled synthetic macromolecular architectures. Based on the current challenges in the field of SCNPs, we discuss potential avenues to break today's barriers and explore future applications reaching beyond the current‐state‐of‐the‐art.

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“…In our previous work, we introduced single chain nanoparticles via photoinduced radical coupling reaction. Pendant benzophenone containing copolymers were subjected to intramolecular crosslinking process under UV–light illumination at high dilution conditions.…”

Section: Introductionmentioning

confidence: 99%

“…Linear copolymers can undergo chemical interactions either by their pendant units or external crosslinkers to achieve intramolecularly crosslinked polymeric nanoparticles. To gain single chain nanoparticles, varying synthetic methods have been carried out such as Menschutkin quaternization chemistry, stepwise folding, Diels–Alder click, benzocyclobutene‐coupling chemistry, click cyclo‐addition, photocrosslinking, and host–guest interactions . These intramolecularly crosslinked nanoparticles have found various applications in gas capturing, controlled release, and nanocomposites …”

Section: Introductionmentioning

confidence: 99%

Preparation of Single Chain Nanoparticles via Photoinduced Double Collapse Process

Dashan

Balta

Temel

et al. 2019

Macro Chemistry & Physics

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A straightforward method is described to achieve polymeric nanoparticles by double folding of single linear chains. The side chain functional polystyrene with controlled molecular weight is converted to pendant azide and benzophenone motifs via postmodification reactions. Resulting functionalized chains undergo intramolecular crosslinking upon ultraviolet (UV) illumination using simultaneous and subsequent pathways at a dilute concentration. Particle size of nanoparticles can be tuned by changing the degree of crosslinking using a second folding process. Obtained single and double collapsed chains indicate higher glass transition temperatures and lower hydrodynamic radii compared to their intermediates. To our knowledge, the combination of photoinduced azide crosslinking and radical coupling processes is the first attempt to prepare double folding single polymer chains.

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Preparation of single chain nanoparticles via photoinduced radical coupling process

Cited by 16 publications

References 55 publications

Post‐Polymerization Thiol Substitutions Facilitated by Mechanochemistry

Post‐Polymerization Thiol Substitutions Facilitated by Mechanochemistry

Macromolecular Superstructures: A Future Beyond Single Chain Nanoparticles

Preparation of Single Chain Nanoparticles via Photoinduced Double Collapse Process

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