Preparation of S-Containing Aminophosphine and Phosphoramidite Ligands and Their Applications in Enantioselective C–C Bond Forming Reactions

Abstract

A series of phosphorus/sulfur ligands were readily prepared and successfully applied in the Pd-catalyzed enantioselective allylic substitution and Cu-catalyzed conjugated additions of cyclic enones, respectively. The Pd-catalyzed enantioselective allylic substitution showed the best yield of 98% with 74% ee. For the Cu-catalyzed conjugated additions of cyclic enones, the best yield of 100% with 76% ee at the temperature of -30°C could be obtained.

Enantioselective Organocatalytic Sulfenylation of β-Naphthols

“…The organosulfur compounds are commonly occurring in natural products and drug molecules . Among them, chiral sulfides display numerous biological activities, which also serve as indispensable intermediates in synthetic organic chemistry . Consequently, developing the protocols for C–S bond formations has attracted a great deal of interest among researchers at the forefront of investigation and innovation in modern synthetic organic chemistry.…”