Preparation of ROS active and photothermal responsive hydroxyapatite nanoplatforms for anticancer therapy

Chang, Linna; Huang, Sichao; Zhao, Xian; Hu, Yanan; Ren, Xiuli; Mei, Xifan; Chen, Zhenhua

doi:10.1016/j.msec.2021.112098

Cited by 33 publications

(19 citation statements)

References 45 publications

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“…It employs nanoparticles to transform near-infrared light into heat for cell ablation. Chang et al [43] found IR-780 modified hydroxyapatite nanorods as photothermic agents and reported an efficiency of 69.3% followed by photostability after four irradiation cycles. Furthermore, Li et al [44] assessed polymer nanoenzymes for enhanced cancer therapy and observed a 3.5-fold enhancement in photothermal therapy.…”

Section: Journal Of Nanomaterialsmentioning

confidence: 99%

A Review on Environmental and Economic Impact of 2D Nanomaterials-Based Heat Transfer Fluids

Shaik

Goyal

et al. 2022

Journal of Nanomaterials

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2D nanomaterials-based heat transfer fluids show excellent thermal properties due to their large specific surface area; hence, they find large-scale applications in automobile industries and cooling processes. Therefore, it is very essential to study the environmental and economic aspects of these 2D nanomaterial-based nanofluids. In this review, we have discussed the environmental impact of 2D nanomaterial-based heat transfer nanofluids under various conditions. The environmental impact analysis of these materials has shown excellent capability in reducing the energy consumption for heat transfer operations. Moreover, the possibility of nanomaterials and base fluid recovery makes it a sustainable alternative. In addition, health risk assessment on humans, cytotoxicity, and life cycle analysis have also been explored. The price-performance index has been successfully used to study the economic impact of 2D nanomaterial-based heat transfer fluids. The overall economic impact of 2D nanomaterial-based heat transfer nanofluids provides an optimistic perspective over conventional heat transfer fluids. Moreover, graphene production, market trend, and commercialization obstacles were also discussed.

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Section: Journal Of Nanomaterialsmentioning

confidence: 99%

A Review on Environmental and Economic Impact of 2D Nanomaterials-Based Heat Transfer Fluids

Shaik

Goyal

et al. 2022

Journal of Nanomaterials

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“…Surgery, hepatic artery ligation, hepatic artery chemoembolization, radiofrequency, cryo, laser, microwave, chemotherapy, and radiotherapy are some of the treatment options ( Cammarota et al, 2021 ; Carballo-Folgoso et al, 2021 ; Hu et al, 2021a ; Monge et al, 2021 ; Su et al, 2021 ). HCC is also treated with biological therapy and traditional Chinese medicine ( Chang et al, 2021 ; Luo et al, 2021 ; Oura et al, 2021 ; Sorop et al, 2021 ). These conventional therapies have limitations such as side effects, low bioavailability, and poor efficacy.…”

Section: Introductionmentioning

confidence: 99%

“…With the development of medicine and the progress of chemotherapy, photothermal therapy (PTT) has gradually attracted people’s attention. Its low side effects and high efficiency make it an emerging cancer treatment method ( Zheng et al, 2020 ; Chang et al, 2021 ; Cui et al, 2021 ; Shen et al, 2021 ). Photothermal responses are exploited as nanoplatforms to promote bacterial infection wound healing and treat arthritis ( Ding et al, 2021 ; Xu et al, 2021 ; Xu et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Preparation of NIR-Responsive Gold Nanocages as Efficient Carrier for Controlling Release of EGCG in Anticancer Application

Gao¹,

Fan

Bi³

et al. 2022

Front. Chem.

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Hepatocellular carcinoma (HCC) is a type of cancer that has a restricted therapy option. Epigallocatechin gallate (EGCG) is one of the main biologically active ingredients in tea. A large number of studies have shown that EGCG has preventive and therapeutic effects on various tumors. In addition, the development of near-infrared (NIR)-responsive nano-platforms has been attracting cancer treatment. In this work, we designed and synthesized a strategy of gold nanocages (AuNCs) as an efficient carrier for controlling release of EGCG for anti-tumor to achieve the synergistic functions of NIR-response and inhibited tumor cell proliferation. The diameter of AuNCs is about 50 nm and has a hollow porous (8 nm) structure. Thermal imaging-graphic studies proved that the AuNCs-EGCG obtained have photothermal response to laser irradiation under near-infrared light and still maintain light stability after multiple cycles of laser irradiation. The resulted AuNCs-EGCG reduced the proliferation rate of HepG2 cells to 50% at 48 h. Western blot analysis showed that NIR-responsive AuNCs-EGCG can promote the expression of HepG2 cell apoptosis-related proteins HSP70, Cytochrome C, Caspase-9, Caspase-3, and Bax, while the expression of Bcl-2 is inhibited. Cell confocal microscopy analysis proved that AuNCs-EGCG irradiated by NIR significantly upregulates Caspase-3 by nearly 2-fold and downregulates Bcl-2 by nearly 0.33-fold, which is beneficial to promote HepG2 cell apoptosis. This study provides useful information for the NIR-responsive AuNCs-EGCG as a new type of nanomedicine for HCC.

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“…So far, metal nanostructures (such as nanoparticles, nanorods, and nanolayers) and two-dimensional (2D) nanomaterials (such as black phosphorus, Prussian blue, and copper sulfide) have been used as photothermic agents for near-infrared absorption. These excellent pioneer works disclosed the brilliant prospect of multifunctional nanoplatforms based on PTT strategy ( Gupta et al, 2019 ; Chen et al, 2020a ; Tong et al, 2020 ; Chang et al, 2021 ). It is well known that gold nanocages are the basic elements used by people for a long time, which is also a kind of photothermic agent.…”

Section: Introductionmentioning

confidence: 99%

An NIR-Triggered Au Nanocage Used for Photo-Thermo Therapy of Chronic Wound in Diabetic Rats Through Bacterial Membrane Destruction and Skin Cell Mitochondrial Protection

et al. 2021

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Bacterial infection and its severe oxidative stress reaction will cause damage to skin cell mitochondria, resulting in long-lasting wound healing and great pain to patients. Thus, delayed wound healing in diabetic patients with Staphylococcus aureus infection is a principal challenge worldwide. Therefore, novel biomaterials with multifunction of bacterial membrane destruction and skin cell mitochondrial protection are urgently needed to be developed to address this challenge. In this work, novel gold cage (AuNCs) modified with epigallocatechin gallate (EGCG) were prepared to treat delayed diabetic wounds. The results showed that Au-EGCG had a high and stable photothermal conversion efficiency under near-infrared irradiation, and the scavenging rate of Au-EGCG for S. aureus could reach 95%. The production of large amounts of reactive oxygen species (ROS) leads to the disruption of bacterial membranes, inducing bacterial lysis and apoptosis. Meanwhile, Au-EGCG fused into hydrogel (Au-EGCG@H) promoted the migration and proliferation of human umbilical cord endothelial cells, reduced cellular mitochondrial damage and oxidative stress in the presence of infection, and significantly increased the basic fibroblast growth factor expression and vascular endothelial growth factor. In addition, animal studies showed that wound closure was 97.2% after 12 days of treatment, and the healing of chronic diabetic wounds was significantly accelerated. Au-EGCG nanoplatforms were successfully prepared to promote cell migration and angiogenesis in diabetic rats while removing S. aureus, reducing oxidative stress in cells, and restoring impaired mitochondrial function. Au-EGCG provides an effective, biocompatible, and multifunctional therapeutic strategy for chronic diabetic wounds.

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Preparation of ROS active and photothermal responsive hydroxyapatite nanoplatforms for anticancer therapy

Cited by 33 publications

References 45 publications

A Review on Environmental and Economic Impact of 2D Nanomaterials-Based Heat Transfer Fluids

A Review on Environmental and Economic Impact of 2D Nanomaterials-Based Heat Transfer Fluids

Preparation of NIR-Responsive Gold Nanocages as Efficient Carrier for Controlling Release of EGCG in Anticancer Application

An NIR-Triggered Au Nanocage Used for Photo-Thermo Therapy of Chronic Wound in Diabetic Rats Through Bacterial Membrane Destruction and Skin Cell Mitochondrial Protection

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