Preparation of ropivacaine loaded PLGA microspheres as controlled-release system with narrow size distribution and high loading efficiency

Li, Xun; Yi, Wei; Lv, Piping; Wu, Youbin; Ogino, Kenji; Ma, Guanghui

doi:10.1016/j.colsurfa.2018.11.014

Cited by 31 publications

(12 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It can also reduce unnecessary oxygen consumption, prevent maternal and infant metabolic acidosis, reduce uteroplacental blood ow, and improve fetal oxygen and condition [8]. Related studies have found that dexmedetomidine can stable hemodynamics and analgesia, improve the e ect of the local anesthesia in cesarean section, and avoid the occurrence of adverse events [9][10][11]. In addition, ropivacaine can reduce the immune stress response of the parturients, so the combined use of the two exerts a promising clinical effect.…”

Section: Introductionmentioning

confidence: 99%

The Effectiveness and Safety of Ropivacaine and Medium-Dose Dexmedetomidine in Cesarean Section

Huang

Niu

2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Objective: To study the effects of epidural anesthesia with different doses of dexmedetomidine and ropivacaine on postoperative hemodynamics and neonatal outcome of cesarean section parturients. Methods. A total of 90 parturients who underwent cesarean section admitted to our hospital from January 2019 to January 2020 were selected as the research objects and were divided into groups A, B, and C according to different dosages of dexmedetomidine, with 30 cases in each group. Groups A, B, and C were given dexmedetomidine 0.5 μg/kg, 0.8 μg/kg, 1.0 μg/kg, respectively, combined with 0.2% ropivacaine. The anesthesia effect, traction response, hemodynamic indexes, and neonatal Apgar score of the three groups were compared; the “Numerical Rating Scale (NRS) Score” was used to assess the postoperative pain of the parturients, and the “Ramsay Sedation Scale” was used to assess the sedation state of the parturients. Results. The superior anesthesia effect of group B was obtained compared with groups A and C ( P < 0.05 ). Group B witnessed a lower degree of grade III stretching response, as compared to group A ( P < 0.05 ). In comparison with groups A and C, superior results of the heart rate and mean artery pressure (MAP) of group B at T1 and T2 were obtained ( P < 0.05 ). The neonatal Apgar score in group B was lower than those in groups A and C ( P < 0.05 ), and the NRS score of group B was also lower than that of group A ( P < 0.05 ). Compared with groups A and C, group B yielded a more favorable outcome in terms of the Ramsay score ( P < 0.05 ). Conclusion. The use of medium-dose dexmedetomidine in cesarean section parturients is safer and can effectively reduce the impact on maternal hemodynamics, which is worthy of promotion and application.

show abstract

Section: Introductionmentioning

confidence: 99%

The Effectiveness and Safety of Ropivacaine and Medium-Dose Dexmedetomidine in Cesarean Section

Huang

Niu

2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“… 21 The concentration NPs solutions was measured using direct UV absorbance detection at 371 nm. Loading efficiency (LE) and process yield were calculated according to the follow 22 :…”

Section: Methodsmentioning

confidence: 99%

Preparation, Physicochemical Characterization and Anti-Fungal Evaluation of Amphotericin B-Loaded PLGA-PEG-Galactosamine Nanoparticles

et al. 2020

View full text Add to dashboard Cite

Purpose: The present study aimed to formulate PLGA and PLGA-PEG-galactosamine nanoparticles (NPs) loaded with amphotericin B with appropriate physicochemical properties and antifungal activity. PLGA was functionalized with GalN to increase the adhesion and antifungal activity of NPs against Candida albicans . Methods: The physicochemical properties of NPs were characterized by particle size determination, zeta potential, drug crystallinity, loading efficiency, dissolution studies, differential scanning calorimeter (DSC), X-ray powder diffraction (XRPD), and Fourier transform infrared (FT-IR). Antifungal activity of the NPs at different drug/polymer ratios was examined by determining minimum inhibitory concentrations (MICs). Results: the FT-IR and 1 HNMR analysis successfully confirmed the formation of PLGA- PEG-GalN NPs. The PLGA NPs were in the size range of 174.1 ± 3.49 to 238.2±7.59 nm while PLGA-GalN NPs were 255.6 ±4.08 nm in size , respectively. Loading efficiency was in the range of 67%±2.4 to 77%±1.6, and entrapment efficiency in the range of 68.185%±1.9 to 73.05%±0.6. Zeta potential and loading efficiency for PLGA-GalN NPs were –0.456, 71%. The NPs indicated an amorphous status according to XRPD patterns and DSC thermograms. The PLGA-PEG-GalN NPs showed higher fungistatic activity than PLGA NPs. Conclusion: the results demonstrated that the antifungal activity of PLGA-PEG-GalN NPs was higher than pure amphotericin B and PLGA NPs.

show abstract

“…Another MPG membrane, developed by Senhui Microsphere Tech. Co., Ltd. (China), has been reported for the formation of various micro-/nanoparticles through PME [41][42][43][44][45]. Closely related to glass membranes are the ceramic membranes that are fabricated from inorganic materials such as aluminum oxide (Al2O3), zirconium oxide (ZrO2), titanium oxide (TiO2), mullite (3Al2O3•2SiO2), and silicon oxycarbide (SiOC).…”

Section: Glass and Ceramic Membranesmentioning

confidence: 99%

Droplet breakup mechanisms in premix membrane emulsification and related microfluidic channels

Nazir

Vladisavljević

2021

Advances in Colloid and Interface Science

View full text Add to dashboard Cite

Preparation of ropivacaine loaded PLGA microspheres as controlled-release system with narrow size distribution and high loading efficiency

Cited by 31 publications

References 36 publications

The Effectiveness and Safety of Ropivacaine and Medium-Dose Dexmedetomidine in Cesarean Section

The Effectiveness and Safety of Ropivacaine and Medium-Dose Dexmedetomidine in Cesarean Section

Preparation, Physicochemical Characterization and Anti-Fungal Evaluation of Amphotericin B-Loaded PLGA-PEG-Galactosamine Nanoparticles

Droplet breakup mechanisms in premix membrane emulsification and related microfluidic channels

Contact Info

Product

Resources

About