Preparation of rifampicin/poly(d,l-lactice) nanoparticles for sustained release by supercritical assisted atomization technique

Zinc Alginate Beads for the Controlled Release of Rifampicin

“…Many of these systems suffer from problems like lower drug entrapment, higher cost, safety issues, use of toxic organic solvents and complicating preparation steps 4,5 . Alginate based formulations attracted considerable attention due to its biocompatible nature 6 .…”

Supercritical fluids applications in nanomedicine

“…Rifampicin [66] is one of the most powerful antibiotics used against bacteria, since it can diffuse easily into tissue, living cells and bacteria, making it highly effective against pathogens such as tuberculosis. However, despite being an effective drug for tubercolosis, there are some challenges in treating tubercolosis with Rifampicin.…”

“…The current strategy for limiting adverse side-effects and enhancing therapeutic activity of anti-tubercolosis drugs is via encapsulation within a carrier, from which it is released in a controlled way over an extended period of time. PLLA np s for the controlled and sustained release of Rifampicin were recently produced using SAA [66]. The authors presented a new configuration of SAA plant, in which the M a n u s c r i p t precipitation vessel was equipped with a vacuum pump, to reduce precipitation pressure, allowing the evaporation of the solvent at lower temperatures.…”

Supercritical Assisted Atomization of emulsions for encapsulation of 1-monoacylglycerols in an hydrophilic carrier

“…Among the supercritical based methods, the rapid expansion of supercritical solutions (RESS) [22,23], the supercritical antisolvent precipitation (SAS) [24] and the supercritical assisted atomization (SAA) [25,26] can be mentioned. SAA technique has been also used for the production of microspheres [27,28], is non-aggressive process with respect to the substances treated [18] and can be used for aqueous systems.…”

“…SAA has been successfully used for the micronization of pharmaceuticals [15,16,35,36], polymers and copolymers [34,[37][38][39]. Moreover, this technique has been applied to the production of co-precipitates where carrier and active substance were dissolved in the same solvent [27,28,30]. In some cases, the carrier and the active substance are not soluble in the same solvent, as in the case of a hydrophobic active principle and a hydrophilic polymeric carrier.…”