Preparation of Rapidly Disintegrating Tablets Containing Itraconazole Solid Dispersions

Oshima, Takao; Sonoda, Ryoichi; Ohkuma, Moriyuki; Sunada, Hisakazu

doi:10.1248/cpb.55.1557

Cited by 21 publications

(12 citation statements)

References 14 publications

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“…The non-ionic surfactant Tween 80 was used as the third component in the ternary SD system. 15) Mouth dissolving tablets of itraconazole, 16) valdecoxib, 17) diazepam, 18) glyburide, 19) clonazepam, 20) and rofecoxib 15) were prepared using SD technique. Ibuprofen (IBU) is a propionic acid derivative, non steroidal anti inflammatory drug (NSAIDS).…”

mentioning

confidence: 99%

Development and in Vitro Evaluation of Ibuprofen Mouth Dissolving Tablets Using Solid Dispersion Technique

Jain

Shukla

Shrivastava³

2010

CHEMICAL & PHARMACEUTICAL BULLETIN

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The aim of present study was to prepare and evaluate mouth dissolving tablets of ibuprofen (IBU). Ternary solid dispersion (SD) of IBU was prepared using PEG 4000 as carrier and Tween 80 as surfactant. The SD formulations were prepared by solvent evaporation and melt solvent method by varying ratio of PEG 4000. Different weight ratio of carrier, drug and surfactant 5 : 5 : 1, 10 : 5 : 1, 25 : 5 : 1, 35 : 5 : 1 and 45 : 5 : 1 was taken. The prepared SD formulations were characterized by Fourier Transform Infra-Red (FT-IR) spectroscopy, differential scanning calorimetry (DSC), X-ray diffraction (XRD) and in vitro drug release. Mouth dissolving tablets of IBU were formulated using optimized SD formulation of carrier : drug : surfactant ratio, 10 : 5 : 1 along with superdisintegrants. The best developed formulation was compared with marketed tablet product of IBU. From IR and XRD studies, it may be concluded that there is change in crystalline form of drug into amorphous during formation of SD. From DSC studies, it was predicted that drug was completely dissolved in the carrier. Mouth dissolving tablets containing Ac-Di-Sol (12%) as super-disintegrant showed the fastest disintegration (202s) and in vitro drug release (84.57%). The release pattern of all developed formulations followed Peppas-Korsmeyer model as the plot between log cumulative % drug released versus log time showed good linearity (rϾ0.99) with a comparatively high slope (n) value within the range of 0.44-0.67. The tablets containing SD exhibited better dissolution profile than commercial tablets.

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confidence: 99%

Development and in Vitro Evaluation of Ibuprofen Mouth Dissolving Tablets Using Solid Dispersion Technique

Jain

Shukla

Shrivastava³

2010

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…The flowability of the obtained granules was optimized by adding 0.1 % of light anhydrous silicic acid as surface modifier. The amount of disintegrant was optimized and 2 % of croscarmellose sodium was finally selected (Oshima et al 2007). A similar approach was tested by Chowdary and Rao who applied an organic ITZ solution onto three different superdisintegrants, or lactose or MCC and investigated the dissolution behavior (Chowdary and Rao 2000).…”

Section: Fluid Bed Coating/layering and Spray Granulationmentioning

confidence: 99%

Amorphous Solid Dispersions

Shah¹,

Sandhu²,

Choi³

et al. 2014

Advances in Delivery Science and Technology

108

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“…The solubility and dissolution of aqueous insoluble drugs has been improved by solid dispersion technique, using hydrophilic polymer carriers in which the insoluble drug is dispersed in amorphous state [1]. The solid dispersion technique is highly accepted in pharmaceutical industry in the formulation of water insoluble drugs for increasing their oral absorption [2][3][4][5]. The mechanism involved in the solubility improvement, is the ability of hydrophilic polymer carrier to prevent the drug precipitation in the aqueous environment of GI tract [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…The mechanism involved in the solubility improvement, is the ability of hydrophilic polymer carrier to prevent the drug precipitation in the aqueous environment of GI tract [6][7][8][9][10]. Examples of FDA approved solid dispersions based drugs include Itraconazole, Tacrolimus, lopinavir, Etravirine, Everolimus, Telaprevir, Troglitazone, Nifedipine, verapamil [2][3][4][5][6][7][8][9][10][11]. Solvent evaporation and hot melting methods are utilized mainly in the preparation of solid dispersions [2].…”

Section: Introductionmentioning

confidence: 99%

Investigations on noval method for the formulation of solid dispersions part- I Formulation, characterization and selection

Sharma¹,

Middha²

2017

ijdd

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A b s t r a c tThe solid dispersions of indomethacin with hydrophilic polymers were prepared by lyophilization. The polymers used in the investigation were HPMC, PVP K30, CBR and PLF 127. The solubility and dissolution of indomethacin from prepared lyophilized solid dispersions were investigated in 0.1 N HCl, purified water and USP-NF dissolution media. Out of fifteen lyophilized formulations from F1 to F15, five formulations F2, F5, F8, F12 and F14 showed highest solubility in purified water. Formulation F2, F8 failed to comply with the USP-NF dissolution test for indomethacin capsules. Formulation F14 showed maximum dissolution in the respective dissolution media within 60 min. Sustained drug release was observed for 6 h with formulations F2 and F8 in USP-NF media. The formulations F2, F5, F8, F12 and F14 were characterized by modulated DSC and FT-IR spectroscopy. Some Formulations on stability testing were found physico-chemically stable at accelerated temperature conditions.

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Preparation of Rapidly Disintegrating Tablets Containing Itraconazole Solid Dispersions

Cited by 21 publications

References 14 publications

Development and in Vitro Evaluation of Ibuprofen Mouth Dissolving Tablets Using Solid Dispersion Technique

Development and in Vitro Evaluation of Ibuprofen Mouth Dissolving Tablets Using Solid Dispersion Technique

Amorphous Solid Dispersions

Investigations on noval method for the formulation of solid dispersions part- I Formulation, characterization and selection

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