Preparation of Pure Cellulose Nanofiber via Electrospinning

Abstract

We describe the preparation of cellulose nanofibrous material directly from cellulose solution via electrospinning. The resulting nanofiber is composed of pure cellulose. The spinning procedure can be performed under ambient conditions at room temperature without post-spun treatment. By mixing drugs with the pre-spun cellulose solution, followed by electrospinning, the drug-loaded nanofiber was prepared and the releasing properties were examined with respect to biomedical applications.

Calcium Phosphate Crystallization on Electrospun Cellulose Non‐Woven Fabrics Containing Synthetic Phosphorylated Polypeptides

“…[15,16,18] The pre-spun solutions were prepared by the dissolution of cellulose (cotton cellulose, Sigma-Aldrich) and the synthetic polypeptides, copoly[Ser-(PO 3 H 2 ) X Asp Y ]s (X:Y ¼ 100:0, 75:25, 50:50, 25:75) in trifluoroacetic acid (TFA). The most homogeneous fine fiber network, which does not contain any structural defeats such as beaded fibers, has been obtained at 4.0-4.5 wt.-% of cellulose/TFA.…”

“…The most homogeneous fine fiber network, which does not contain any structural defeats such as beaded fibers, has been obtained at 4.0-4.5 wt.-% of cellulose/TFA. [18] The concentrations of copoly[Ser(PO 3 H 2 ) X Asp Y ]s were determined, on the basis of the fact that native tooth tissue typically contains phosphorylated matrix proteins approximately at 0.1-0.15 weight parts of total organic substances. Hence, the concentrations of the cellulose and the synthetic polypeptides were fixed at 4.5 wt.-% and 0.52 wt.-%, respectively.…”

“…According to the electrospinning conditions described in our previous articles, [15,16,18] in which we optimized the applied voltage at 15 kV and the syringe tip-to-collector distance at 150 mm, the cellulose non-woven fabrics containing copoly[Ser(PO 3 H 2 ) X Asp Y ]s were successfully prepared. SEM images of the non-woven fabrics are shown in Figure 1.…”

“…[13] These results clearly indicated that the Ser(PO 3 H 2 )-containing polypeptides are an effective crystal growth modifier for the calcium biominerals. We have also studied the electrospinning process using natural polysaccharides or synthetic poly(amino acid)s. [14] The thin fibers of chitosan, [15,16] poly(g-benzyl-L-glutamate), [17] cellulose [18] and gelatin [19] were successfully prepared using our electrospinning techniques. We have tried to combine the two concepts in the series of previous studies: one is biomineralization using the synthetic phosphorylated polypeptides and the other is the fabrication of fine fibers using bio-related polymers via electrospinning, in order to produce new composite materials, which can be made from non-woven fabrics and calcium salts.…”

Isolation and Characterization of Cellulose Nanofibers from the Aquatic Weed Water Hyacinth: Eichhornia crassipes

“…The combination of enzymatic treatment and mechanical shearing resulted in preparation of microfibrillated cellulose (MFC) nanofibers from commercial bleached wood sulfite pulps [16]. Electrospinning setup is the latest and the easiest technology for the nanofiber production; it can be used to directly spin from the polymer solutions [17,18]. The TEMPO (2,2,6,6-tetramethylpiperidine-1-oxy radical)-mediated catalytic oxidation method was used to produce nanofibers from native celluloses in aqueous conditions under alkaline pH.…”