Preparation of pro-angiogenic, antibacterial and EGCG-modified ZnO quantum dots for treating bacterial infected wound of diabetic rats

The repair of diabetic wounds has always been a job that doctors could not tackle quickly in plastic surgery. To solve this problem, it has become an important direction to use biocompatible biodegradable biomaterials as scaffolds or dressing loaded with a variety of active substances or cells, to construct a wound repair system integrating materials, cells, and growth factors. In terms of wound healing, composite biodegradable biomaterials show strong biocompatibility and the ability to promote wound healing. This review describes the multifaceted integration of biomaterials with drugs, stem cells, and active agents. In wounds, stem cells and their secreted exosomes regulate immune responses and inflammation. They promote angiogenesis, accelerate skin cell proliferation and re-epithelialization, and regulate collagen remodeling that inhibits scar hyperplasia. In the process of continuous combination with new materials, a series of materials that can be well matched with active ingredients such as cells or drugs are derived for precise delivery and controlled release of drugs. The ultimate goal of material development is clinical transformation. At present, the types of materials for clinical application are still relatively single, and the bottleneck is that the functions of emerging materials have not yet reached a stable and effective degree. The development of biomaterials that can be further translated into clinical practice will become the focus of research.

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“…The safety experiment shows that, ZnO-EGCG@H It has reassuring biocompatibility and is harmless to important organs (Yin et al, 2022).…”

Section: Ag +mentioning

confidence: 99%

Effect of composite biodegradable biomaterials on wound healing in diabetes

Ren

Guo²,

Yang³

et al. 2022

Front. Bioeng. Biotechnol.

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“…While the ZnO based wound dressing film facilitates angiogenesis, it enhances the vascular endothelial growth factor (VEGF) and hypoxia inducible factor (HIF-1 α ) [ 68 ]. Researchers reported that the modified ZnO quantum dots and hydrogel loaded with heparinized ZnO enhanced the healing rate up to more than 90% after 14 days of treatment [ 69 , 70 ]. The same goes to the MWCNT film, and a good healing activity was observed after 14 to 21 days.…”

Section: Resultsmentioning

confidence: 99%

Physicochemical Properties and Antibacterial Activity of Gellan Gum Incorporating Zinc Oxide/Carbon Nanotubes Bionanocomposite Film for Wound Healing

Liu

Ismail

Yusoff

et al. 2022

Bioinorganic Chemistry and Applications

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Wound healing dressing based on a natural polymer of gellan gum incorporating zinc oxide nanoparticles and multiwall carbon nanotubes (GG/ZnONP + MWCNT) bionanocomposite film was fabricated via the solution casting method. The physicochemical properties of the film were characterized using X-ray diffraction (XRD), Fourier transform infrared (FTIR), and scanning electron microscopy (SEM). Moreover, the antibacterial properties of the bionanocomposite film were investigated for wound healing applications. The characterization results confirmed the reinforcement of the gellan gum (GG) matrix with zinc oxide nanoparticles (ZnONP) and multiwall carbon nanotubes (MWCNT), as an amorphous GG/ZnONP + MWCNT bionanocomposite film was obtained. SEM morphological analysis shows that the addition of ZnONP and MWCNT nanofillers changed the film microstructure into a sponge-like structure that is more suitable for fluid uptake and thus more useful for wound healing. The GG/ZnONP + MWCNT bionanocomposite film demonstrated good antibacterial activity against all strains tested. Furthermore, macroscopic analysis shows that the wound treated with GG/ZnONP + MWCNT bionanocomposite film recovered completely (100%) in 14 days, compared to pure GG film (90.76%) and negative control (77.40%). As a result, the GG/ZnONP + MWCNT bionanocomposite film could be a promising wound dressing material.

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“…But with ZnO NPs, the unique properties of the nanoparticle surface act as oxidation-reduction reaction centers, causing a lot of ROS to be made, which leads to the apoptosis of cancer cells [19]. ZnO NPs are also found to hold potential in various applications in the eld of biomedicine, including diabetes treatment [20,21], bioimaging [22,23], drug delivery [24,25], immunotherapy [26,27], pro-angiogenic properties [28,29], and wound healing [30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Glutamic Acid-Coated Zinc Oxide Nanoparticles: Synthesis, Characterization, and Anticancer Activity

Huong,

Son,

Thanh

et al. 2024

Preprint

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This paper presents a method to enhance the compatibility of zinc oxide nanoparticles (ZnO NPs) produced from guava leaf extract by modifying the nanoparticle surface with L-glutamic acid. The Glu-coated ZnO material was subjected to characterization using Fourier transform infrared spectroscopy (FTIR), X-ray scattering spectroscopy (XRD), UV-Vis spectroscopy, and electron energy scattering spectroscopy (EDS). The results corroborated the attachment of glutamic acid to the surface of the nanoparticle. The thermal density analysis (TGA) results indicate that the Glu-coated ZnO material contains around 8.998% organic content. The morphology and size of nanoparticles were assessed using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and dynamic light scattering spectroscopy (DLS) both before and after modification. The findings demonstrate that the bare ZnO nanoparticles had an average size of around 25.32 nm, but the Glu-coated ZnO nanoparticles measure 41.88 nm. Their zeta values are − 9.05 mVs and − 18.6 mV, respectively. The anti-cancer effect of ZnO nanoparticles coated with glutamic acid was evaluated on various cell lines including HeLa (cervical cancer), A549 (lung cancer), and MCF7 (breast cancer). The findings demonstrated a significant enhancement in the anti-cancer efficacy of ZnO NPs with the application of Glu coating on their surface. The IC50 values of Glu-coated ZnO for the Hela, A549, and MCF7 cancer cell lines are 40.43 µg/mL, 37.20 µg/L, and 44.23 µg/mL, respectively. The findings indicate that the utilization of Glu-coated ZnO material holds significant promise in the field of cancer treatment.

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Preparation of pro-angiogenic, antibacterial and EGCG-modified ZnO quantum dots for treating bacterial infected wound of diabetic rats

Cited by 13 publications

References 38 publications

Effect of composite biodegradable biomaterials on wound healing in diabetes

Effect of composite biodegradable biomaterials on wound healing in diabetes

Physicochemical Properties and Antibacterial Activity of Gellan Gum Incorporating Zinc Oxide/Carbon Nanotubes Bionanocomposite Film for Wound Healing

Glutamic Acid-Coated Zinc Oxide Nanoparticles: Synthesis, Characterization, and Anticancer Activity

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