Preparation of PPy/cellulose fibre as an effective potassium diclofenac adsorbent

Pires, Bruna Carneiro; Dutra, Flávia Barbosa da Silva; Nascimento, Tienne Aparecida do; Borges, Keyller Bastos

doi:10.1016/j.reactfunctpolym.2017.02.002

Cited by 43 publications

(6 citation statements)

References 59 publications

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“…The number of different drugs that can be sorbed and would benefit from being formulated with CNFs in a similar way is however presently unknown. Improved understanding might also aid in the development of CNF-based filters that are suitable for wastewater management to prevent poorly soluble drugs (such as diclofenac) from ending up in the environment. , …”

Section: Introductionmentioning

confidence: 99%

“…Improved understanding might also aid in the development of CNF-based filters that are suitable for wastewater management to prevent poorly soluble drugs (such as diclofenac) from ending up in the environment. 9,10 The function and the physicochemical properties of cellulose are strongly related to its micro-to nanostructure. In nature, cellulose is found in the form of microfibrils that assemble further into different layers of the elongated cells that make up the trunk of plants.…”

Section: Introductionmentioning

confidence: 99%

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Toward Improved Understanding of the Interactions between Poorly Soluble Drugs and Cellulose Nanofibers

et al. 2018

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Cellulose nanofibers (CNFs) have interesting physicochemical and colloidal properties that have been recently exploited in novel drug-delivery systems for tailored release of poorly soluble drugs. The morphology and release kinetics of such drug-delivery systems heavily relied on the drug-CNF interactions; however, in-depth understanding of the interactions was lacking. Herein, the interactions between a poorly soluble model drug molecule, furosemide, and cationic cellulose nanofibers with two different degrees of substitution are studied by sorption experiments, Fourier transform infrared spectroscopy, and molecular dynamics (MD) simulation. Both MD simulations and experimental results confirmed the spontaneous sorption of drug onto CNF. Simulations further showed that adsorption occurred by the flat aryl ring of furosemide. The spontaneous sorption was commensurate with large entropy gains as a result of release of surface-bound water. Association between furosemide molecules furthermore enabled surface precipitation as indicated by both simulations and experiments. Finally, sorption was also found not to be driven by charge neutralization, between positive CNF surface charges and the furosemide negative charge, so that surface area is the single most important parameter determining the amount of sorbed drug. An optimized CNF-furosemide drug-delivery vehicle thus needs to have a maximized specific surface area irrespective of the surface charge with which it is achieved. The findings also provide important insights into the design principles of CNF-based filters suitable for removal of poorly soluble drugs from wastewater.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Toward Improved Understanding of the Interactions between Poorly Soluble Drugs and Cellulose Nanofibers

et al. 2018

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“…So far, a variety of methods such as adsorption, [3][4][5][6][7] biodegradation, 8 oxidation, 9 and membrane ltration 10 have been employed to remove different organic micropollutants from wastewater. Amongst these techniques, adsorption using solid adsorbents is an effective method for the removal of organic micropollutants from water.…”

Section: Introductionmentioning

confidence: 99%

Preparation of cationic polymeric nanoparticles as an effective adsorbent for removing diclofenac sodium from water

et al. 2017

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“…The adsorption isotherm could be used to determine the interactions between the adsorbent and heavy metal ions. Besides, the adsorption isotherm reflects the maximum adsorption capacity of the adsorbent which indicates the effects of actual application in water treatment . In the series of adsorption experiments, the initial metal ion concentration varies in the range of 1–1000 mg/L, and the adsorption isotherms for Hg (II) on CGAS are studied at different temperatures which are shown in Figure .…”

Section: Resultsmentioning

confidence: 99%

An Aminosalicylic Acid‐Modified Cellulose Composite Used for Mercury (II) Removal from Single and Quarternary Aqueous Solutions

Pan

et al. 2018

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A high efficient adsorbent based on cellulose with good reusability towards mercury (II) ions was successfully prepared via grafting copolymerization and coupling technology. Batch adsorption experiments were conducted to reveal adsorption behavior of the as-prepared adsorbents. Effects of the initial concentration, pH of the solution, time of contact, temperature and coexisting ions of the system were investigated, respectively. Polymerization reaction via glycidyl methacrylate was carried out to greatly enhance the following graft efficiency with the polydentate ligand which could catch the heavy metal ions. The results indicated the adsorption capacity was as high as 657.9 mg/g for Hg (II). Meanwhile, Langmuir isotherm model was proved to be appropriate in describing the experimental data, and the adsorption process was found to fit well with the pseudo-second-order model. In addition, the adsorbent could be regenerated with high recovery efficiency after adsorption; and the equilibrium adsorption capacity for Hg (II) was maintained at 204.5 mg/g after 10 adsorption-desorption cycles, which is of great importance for practical application.[a] Dr.

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Preparation of PPy/cellulose fibre as an effective potassium diclofenac adsorbent

Cited by 43 publications

References 59 publications

Toward Improved Understanding of the Interactions between Poorly Soluble Drugs and Cellulose Nanofibers

Toward Improved Understanding of the Interactions between Poorly Soluble Drugs and Cellulose Nanofibers

Preparation of cationic polymeric nanoparticles as an effective adsorbent for removing diclofenac sodium from water

An Aminosalicylic Acid‐Modified Cellulose Composite Used for Mercury (II) Removal from Single and Quarternary Aqueous Solutions

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