Preparation of polyvinyl alcohol hydrogel through the selective complexation of amorphous phase

Abstract

Several methods for the preparation of polyvinyl alcohol (PVA) hydrogel are being reported in the literature. In this communication a new, simple, and mild complexation reaction using phenyl boronic acid, leading to a highly elastic PVA hydrogel, is addressed. It is found that the inherent crystalline property of the semicrystalline PVA is retained by the complexation reaction, which is confined to the amorphous region. An enhanced mechanical property, particularly in the wet condition, is observed after the modification resulting from the intact crystallinity. Also, the inherent nontoxic characteristic property of PVA is unaffected upon this complexation reaction.

Exploring poly(vinyl alcohol) hydrogels containing drug–cyclodextrin complexes as controlled drug delivery systems

“…With increasing GA content, there was a remarkable decrease in the crystalline reflection from PVA [Figure (A)]. It has been well established that GA disrupted the crystalline phase of PVA . A similar effect was also observed for the P4C hydrogels [Figure (B)].…”

Surface immobilization of biocompatible phospholipid polymer multilayered hydrogel on titanium alloy

“…However, besides sugar recognition, the usage of polyols such as PVA has permitted the present system to form hydrogels without any chemical crosslinking treatment. Moreover, the use of PVA in hydrogels has attracted considerable attention because of its inherent low toxicity and high degree of swelling in water [33]. The LbL method is a desirable and versatile tool for assembling PMBV and PVA into a multilayered hydrogel.…”

“…Phenylboronic acid in a tetrahedral anionic structure is known to rapidly form a cyclic boronic complex with cis-diols [30], for example, carbohydrates such as glucose, catechol derivatives such as dopamine, and some polymers such as poly(vinyl alcohol) (PVA) [31,32]. The interpolymer complexation of a polymer comprising boronic acid with PVA has been reported to form a hydrogel due to the covalent linkage in both constituent polymers and this hydrogel is reversibly dissociated by the addition of glucose [33][34][35].…”

Synthesis, characterization and efficacy of chemically crosslinked PVA hydrogels for dermal wound healing in experimental animals

“…The swollen gel was then slowly dried to constant weight. The equilibrium water content (EWC) was calculated according to the following formula 9 where, W s and W d refer to the weight of the hydrogel in swollen and dried state, respectively.…”

“…PVA can be crosslinked by different physical or chemical methods such as electron beam, γ‐irradiation,4 repeated freeze‐thaw cycles, photocrosslinking,5–7 reacting with bifunctional reagents like boric acid, phenyl boronic acid, dialdehydes, dicarboxylic acids, dianhydrides, acid chlorides, epichlorohydrin, etc 8–12. However, the crosslinked polymers obtained by the afore‐mentioned techniques decompose during long‐term use, because of the presence of acetal, ester, or urethane bonding linkages, and their stability is also affected in acidic environments.…”