“…29 The zinc insertion shows a remarkable functional group tolerance and most common organic functional groups (i.e. ester,29,35-52 ketone,29,35 cyanide,29,35-43,47,49-52,54 halide, 29,35,43,48,50,52 iV^V-bis(trimethylsilyl)amino group,55 primary and secondary amino groups,56 amide and phthalimide,25,56,57 trialkoxysilyl group,58 sulfoxide,59 sulfide,59 sulfone,59,60 thioester,60 boronic ester,46,48,50 enone,40,53 and phosphate39,61) can be present during the organozinc formation (eq 5). Only hydroxyl groups (deprotonation) or nitro and azide functionalities (inhibition of the zinc insertion) cannot be present in the alkyl iodide.…”