Preparation of polyethersulfone–alginate microcapsules for controlled release

Abstract

In this study, polyethersulfone (PES)-alginate microcapsules were prepared for drug-controlled release, and vitamin B 12 (VB 12 ), rifampicin (RFP), and bovine serum albumin (BSA) were used as model drugs. Different microcapsules were prepared by the variation of the crosslinking degree of alginate and the variation of the chemical components of the microcapsule membrane, including the PES and polyethylene glycol (PEG) contents. Systematic experiments were carried out to study their influences on the release profile of the model drugs. The results showed that with the increase of the crosslinking degree of the alginate, the drug release rate increased; whereas with the increase of the PES concentration used to prepare the microcapsule membrane, the drug release rate decreased. The contents of the PEG in the microcapsule membrane also affected the drug release. This study enriched the methodology of the fabrication of the microcapsules, and the microcapsules may have a potential use for controlled release.

Microspherical hydrogel particles based on silica nanoparticle-webbed polymer networks

“…Various approaches have been explored to address these challenges [35][36][37][38]. For example, polymer beads that efficiently encapsulate bioactive materials have been prepared by phase separation [35], and in situ polymerization [36]. Microparticles with improved shape have been fabricated by combining a phase-separation process with in situ polymerization of the polymeric particles [37].…”

“…However, it is still difficult to fabricate uniform beads with controlled shape and size for specific applications. Various approaches have been explored to address these challenges [35][36][37][38]. For example, polymer beads that efficiently encapsulate bioactive materials have been prepared by phase separation [35], and in situ polymerization [36].…”

Electrosprayed porous microspheres for the removal of endocrine disruptors

“…Because the water was selected as the coagulation medium, PEG would be dissolved into water. But part of PES and PEG molecular chains might be in entanglement, so there was residual PEG in the microspheres 23. The maximum fraction of chains entanglement between PES and PEG content was limited by PES amount, so the fraction of PEG does not increased significantly with the increase of initial PEG [shown in Fig.…”

“…The porosity of microspheres was estimated from the density of polymer and the weight change before and after drying, as the following formula:23 where W B is the weight of microspheres before drying (g); W A is the weight of microspheres after drying (g); ρ W (1.0 g/cm 3 ) is the density of water; and ρ P (1.43 g/cm 3 ) is the density of the PES; C% is the additive ratio in microspheres; ρ C is the density of additive (PEG).…”

Microfluidic one-step synthesis of alginate microspheres immobilized with antibodies

“…Poly-L-lysine is non-toxic and can be used as a drug carrier [23]. PEG200 is non-toxic and it has been used in toothpastes [24]. All these additives should improve the stiffness and rsif.royalsocietypublishing.org J R Soc Interface 10: 20130566…”