Preparation of poly(ε‐caprolactone)/poly(ε‐caprolactone‐<i>co</i>‐lactide) (PCL/PLCL) blend filament by melt spinning

Scaffolds of polycaprolactone (PCL) and PCL composites reinforced with b-tricalcium phosphate (b-TCP) were manufactured aiming potential tissue engineering applications. They were fabricated using a three-dimensional (3D) mini-screw extrusion printing, a novel additive manufacturing process, which consists in an extrusion head coupled to a 3D printer based on the Fab@Home equipment. Thermal properties were obtained by differential scanning calorimetry and thermogravimetric analyses. Scaffolds morphology were observed using scanning electron microscopy and computed microtomography; also, reinforcement presence was observed by X-ray diffraction and the polymer chemical structure by Fourier transform infrared spectroscopy. Mechanical properties under compression were obtained by using a universal testing machine and hydrophilic properties were studied by measuring the contact angle of water drops. Finally, scaffolds with 55% of porosity and a pore size of 450 lm have shown promising mechanical properties; the b-TCP reinforcement improved mechanical and hydrophilic behavior in comparison with PCL scaffolds. V C 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43031.

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“…Crystallinity degree of PCL was determined using eq. , where Δ H m 0 = 139.5 (J/g) and ω is the polymer weight fraction.

χ_{c} (%) = true(\frac{Δ H_{m}}{Δ H_{m}^{0} \cdot ω} true) \times 100

…”

Section: Resultsmentioning

confidence: 99%

Fabrication of PCL/β‐TCP scaffolds by 3D mini‐screw extrusion printing

Dávila

Freitas

Neto

et al. 2015

J of Applied Polymer Sci

107

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“…This is thought to represent the semi‐crystalline lactide in the PLCL. The XRD measurements also confirmed that PLCL67/PLGA33, PLCL33/PLGA67, and PLCL50/PLGA50 show strong peaks at 2 θ = 16.7 and 18.9° and also a weak peak at 22.5°, that is peak of PCL . This supposes that the blending of the two non‐crystalline polymers has helped increase the degree of structural crystallization.…”

Section: Resultsmentioning

confidence: 52%

Shape‐Memory Effect by Specific Biodegradable Polymer Blending for Biomedical Applications

Jin

Lih

Choi

et al. 2014

Macromolecular Bioscience

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Specific biodegradable polymers having shape-memory properties through "polymer-blend" method are investigated and their shape-switching in body temperature (37 °C) is characterized. Poly(L-lactide-co-caprolactone) (PLCL) and poly(L-lactide-co-glycolide) (PLGA) are dissolved in chloroform and the films of several blending ratios of PLCL/PLGA are prepared by solvent casting. The shape-memory properties of films are also examined using dynamic mechanical analysis (DMA). Among the blending ratios, the PLCL50/PLGA50 film shows good performance of shape-fixity and shape-recovery based on glass transition temperature. It displays that the degree of shape recovery is 100% at 37 °C and the shape recovery proceeds within only 15 s. In vitro biocompatibility studies are shown to have good blood compatibility and cytocompatibility for the PLCL50/PLGA50 films. It is expected that this blended biodegradable polymer can be potentially used as a material for blood-contacting medical devices such as a self-expended vascular polymer stents and vascular closure devices in biomedical applications.

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“…As an example, the crystallinity of the PCL used to synthesize PU 1 was calculated to be 83%. It was obtained by following Equation

Crystallinity (%) = \frac{Δ H f \times 100}{Δ H f (crys)}

where Δ Hf is the melting enthalpy of the sample and Δ Hf (crys) is the melting enthalpy of 100% crystalline PCL and was taken as 139.5 J g −1 .…”

Section: Resultsmentioning

confidence: 99%

Catalyst‐Free Ring Opening Synthesis of Biodegradable Poly(ester‐urethane)s Using Isosorbide Bio‐Based Initiator

Mahdi

M'sahel

Medimagh³

2017

Macro Chemistry & Physics

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Polycaprolactones are obtained via ring opening polymerization of ε‐caprolactone in catalyst‐free condition. The polymerization is initiated in bulk, using isosorbide‐based amino‐alcohol as a biosourced initiator. The ratio of initiator to ε‐caprolactone, as well as to temperature, is optimized in order to tune the hydroxyl number (Nr. OH) and the average molecular weight of the polymers. In addition, these biocompatible polyesters are used as soft‐block to prepare thermoplastic poly(esterurethane)s elastomers via a simple one‐pot catalyst‐free polymerization. The successful synthesis of poly(esterurethane)s is confirmed by Fourier transform‐infrared spectroscopy, and the thermal properties are studied by differential scanning calorimetry. These novel materials exhibit glass transition temperatures ranging from 7 to 38 °C. The biodegradability of these elastomers is evaluated by enzymatic degradation tests performed at rt in phosphate buffer solution (pH ≈ 7.4). The mass loss of polymer films is around 3% after 4 weeks. Scan electron as well as atomic force microscopies are used to show the degradation patterns.

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Preparation of poly(ε‐caprolactone)/poly(ε‐caprolactone‐co‐lactide) (PCL/PLCL) blend filament by melt spinning

Cited by 48 publications

References 43 publications

Fabrication of PCL/β‐TCP scaffolds by 3D mini‐screw extrusion printing

Fabrication of PCL/β‐TCP scaffolds by 3D mini‐screw extrusion printing

Shape‐Memory Effect by Specific Biodegradable Polymer Blending for Biomedical Applications

Catalyst‐Free Ring Opening Synthesis of Biodegradable Poly(ester‐urethane)s Using Isosorbide Bio‐Based Initiator

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