Preparation of Poly (methacrylic acid)–Graphene Oxide Nanocomposite as a pH-Sensitive Drug Carrier Through in-situ Copolymerization of Methacrylic Acid with Polymerizable Graphene

Mahkam, Mehrdad; Rafi, Abdolrahim Abbaszad; Faraji, Leila; Zakerzadeh, Elham

doi:10.1080/03602559.2014.961081

Cited by 32 publications

(7 citation statements)

References 55 publications

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“…The diffraction pattern of pure Gr (Fig. 1(a)) shows a very intense, sharp peak at 2 θ = 26.27°, attributed to the diffraction of the (002) graphite plane composed of highly organized layers with an interlayer spacing of 0.34 nm [34, 35]. After oxidative exfoliation of Gr, the characteristic peak of Gr was no longer visible and a new strong sharp peak at 2 θ = 10.15° was observed which is attributed to the diffraction of the (001) for GO (Fig.…”

Section: Resultsmentioning

confidence: 99%

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Graphene Oxide-Gallic Acid Nanodelivery System for Cancer Therapy

et al. 2016

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Despite the technological advancement in the biomedical science, cancer remains a life-threatening disease. In this study, we designed an anticancer nanodelivery system using graphene oxide (GO) as nanocarrier for an active anticancer agent gallic acid (GA). The successful formation nanocomposite (GOGA) was characterized using XRD, FTIR, HRTEM, Raman, and UV/Vis spectroscopy. The release study shows that the release of GA from the designed anticancer nanocomposite (GOGA) occurs in a sustained manner in phosphate-buffered saline (PBS) solution at pH 7.4. In in vitro biological studies, normal fibroblast (3T3) and liver cancer cells (HepG2) were treated with different concentrations of GO, GOGA, and GA for 72 h. The GOGA nanocomposite showed the inhibitory effect to cancer cell growth without affecting normal cell growth. The results of this research are highly encouraging to go further for in vivo studies.

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Section: Resultsmentioning

confidence: 99%

“…Pure Gr spectrum (Fig. 2(a)) shows a broad peak at 3449 cm −1 attributed to the existence of moisture in the pristine Gr [34]. The peak at 1635 cm −1 is assigned to stretching vibrations of C=C bonds.…”

Section: Resultsmentioning

confidence: 99%

Graphene Oxide-Gallic Acid Nanodelivery System for Cancer Therapy

et al. 2016

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“…The status of hydrogels would change from gelation to solution aer changing of pH. 51 Functional drugs wrapped in graphene-based hydrogels would be released gradually. Graphene-based hydrogels could not only protect drugs changing characters by digestive juice, but also control the speed of drugs' releasing by regulating the ratio of composition materials of hydrogels.…”

Section: Hydrogels As Additives For Delivering or Controlling Releasimentioning

confidence: 99%

Applications of graphene-based composite hydrogels: a review

Zhang

Guo

et al. 2017

RSC Adv.

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“…It has been reported that GO can easily be mixed with different polymers to enhance the properties of composite materials, Technical Editor: José Roberto de França Arruda. such as tensile strength, elasticity, and conductivity [13]. Therefore, it would be interesting and significant to examine the enhancing effect of GO on the functionally graded (FG) polymer composite structures.…”

Section: Introductionmentioning

confidence: 99%

Vibration analysis of functionally graded graphene oxide-reinforced composite beams using a new Ritz-solution shape function

Wang

Xie

2020

J Braz. Soc. Mech. Sci. Eng.

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In this study, a new Ritz-solution shape function, in the form of a combination of polynomials and general exponential functions for various boundary conditions, is constructed from two-dimensional elasticity solutions using an inverse method. In conjunction with an improved third-order shear deformation theory, a reliable and accurate model is developed for the analysis of the mechanical behavior of composite beams. Free and forced vibrations of a functionally graded (FG) polymer nanocomposite beam reinforced with a low content of graphene oxide (GO) and excited by a moving load with a constant velocity are investigated. The weight fraction of the GOs is assumed to vary continuously and smoothly in the thickness direction. The modified Halpin-Tsai micromechanics model is used to evaluate the effective Young's modulus of the FG GOreinforced composites. The governing equations of motion are derived using the Lagrange method. The Newmark-β method is adopted to solve the forced vibration problem of a beam subjected to a moving load. A parametric study is conducted to demonstrate the effects of GO distribution patterns, weight fraction, and size on the vibration response of the nanocomposite beam with various classical boundary conditions.

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Preparation of Poly (methacrylic acid)–Graphene Oxide Nanocomposite as a pH-Sensitive Drug Carrier Through in-situ Copolymerization of Methacrylic Acid with Polymerizable Graphene

Cited by 32 publications

References 55 publications

Graphene Oxide-Gallic Acid Nanodelivery System for Cancer Therapy

Graphene Oxide-Gallic Acid Nanodelivery System for Cancer Therapy

Applications of graphene-based composite hydrogels: a review

Vibration analysis of functionally graded graphene oxide-reinforced composite beams using a new Ritz-solution shape function

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