Preparation of poly(l-lactic acid)-polysiloxane-calcium carbonate hybrid membranes for guided bone regeneration

Maeda, Hirotaka; Kasuga, Toshihiro; Hench, Larry L.

doi:10.1016/j.biomaterials.2005.08.010

Cited by 81 publications

(54 citation statements)

References 20 publications

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“…Composite scaffolds using synthetic polymers and ceramic phases have been produced in the recent years (Kim et al 2006, Maeda et al 2006. However, as each scaffold consists of some phase which is not found naturally in the human body, they have all exhibited drawbacks with biocompatibility, biodegradability or osteconductivity (Rezwan et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Influence of a novel calcium-phosphate coating on the mechanical properties of highly porous collagen scaffolds for bone repair

Al-Munajjed

O’Brien

2009

Journal of the Mechanical Behavior of Biomedical Materials

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Section: Introductionmentioning

confidence: 99%

Influence of a novel calcium-phosphate coating on the mechanical properties of highly porous collagen scaffolds for bone repair

Al-Munajjed

O’Brien

2009

Journal of the Mechanical Behavior of Biomedical Materials

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“…Fibrous membranes are promising as GBR materials due to their high and breathable interconnected porosity [3][4][5][6][7][8]. This allows efficient transport of nutrient and oxygen into and metabolic waste out of the regeneration site.…”

Section: Introductionmentioning

confidence: 99%

Modification and mechanical properties of electrospun blended fibermat of PLGA and siloxane-containing vaterite/PLLA hybrids for bone repair

Poologasundarampilla¹,

Poologasundarampillai

Fujikura

et al. 2011

Express Polym. Lett.

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Abstract. Multi-syringe electrospinning has been successfully employed to produce a blended fibermat composed of poly(lactic-glycolic acid) (PLGA) fibers and a composite fiber for bone repair. The composite fiber, siloxane-containing vaterite (SiV)/poly(L-lactic acid) (PLLA), donated as SiPVH has the ability to release soluble silica species and calcium ions at a controlled rate. The SiPVH fibermats have demonstrated excellent bone regeneration ability in vivo at the front midline of the calvaria of rabbits. However, they are brittle and have low tensile strength resulting from the large particulate SiV (60 wt%) content. In this study, co-electrospinning of PLGA with SiPVH was performed in the hope of achieving a blended fibermat with improved mechanical properties. The co-electrospun fibermats showed good homogeneous blending of the PLGA and SiPVH composite fibers that had excellent flexibility. The blended PLGA-SiPVH fibermats had significantly improved mechanical properties compared to the SiPVH fibermats, where more than 20 times higher elongation to failure was achieved on comparison to the SiPVH fibermat. As well as strength, high porosity and large pore size are vital for the migration of cells into the centre of the graft. This was accomplished by heating the PLGA-SiPVH fibermats at 110°C for a fixed time, which induced the softening and flow of PLGA towards the more stable SiPVH fibers. Heating had successfully produced PLGA-SIPVH fibermats with large open pores and inter-fused SiPVH fibers, which also had better tensile mechanical properties than the SiPVH fibermat.

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“…14), 15) In our earlier work, siloxane-containing polymer-inorganic (calcium carbonate-vaterite) hybrids with the releasing ability of silicate ion was prepared. 16), 17) The materials were shown to enhance proliferation and differentiation of the murine osteoblast-like cells. 18) The siloxane containing inorganic particles (SiV) derived from aminopropyltriethoxysilane (APTES) and vaterite was hybridized with poly (L-lactic acid) (PLLA) through the formation of amide bond between siloxane and PLLA through the amino groups and coordination of calcium ion in the vaterite to the carboxylic group in PLLA (these hybrids were denoted as SiPVHs).…”

Section: Introductionmentioning

confidence: 99%

Preparation of siloxane-containing vaterite/poly (L-lactic acid) hybrid microbeads with silicate and calcium ions-releasing ability

Nakamura

Poologasundarampillai

Obata

et al. 2010

J. Ceram. Soc. Japan

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Siloxane-containing vaterite (SiV)/poly (L-lactic acid) (PLLA) hybrids have the releasing-ability of silicate and calcium ions for gene-activation. In the present paper a new types of beads were prepared using the hybrids via an electrospraying method. The diameters of the beads were controlled in the range of ³65 to ³180¯m by increasing the feeding rate from 0.1 to 0.9 ml/min. Depressed areas could be observed on the surface of the beads. The SiV particles with concentration of 10 and 20 wt % in the beads were completely enclosed by the PLLA matrix. These beads showed the controlled release of silicate and calcium ions in Tris buffer solution.

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Preparation of poly(l-lactic acid)-polysiloxane-calcium carbonate hybrid membranes for guided bone regeneration

Cited by 81 publications

References 20 publications

Influence of a novel calcium-phosphate coating on the mechanical properties of highly porous collagen scaffolds for bone repair

Influence of a novel calcium-phosphate coating on the mechanical properties of highly porous collagen scaffolds for bone repair

Modification and mechanical properties of electrospun blended fibermat of PLGA and siloxane-containing vaterite/PLLA hybrids for bone repair

Preparation of siloxane-containing vaterite/poly (L-lactic acid) hybrid microbeads with silicate and calcium ions-releasing ability

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