Preparation of poly(L-lactic acid) microfiltration membranes by a nonsolvent-induced phase separation method with the aid of surfactants

Minbu, Hiromi; Ochiai, Akihito; Kawase, Tomoyuki; Taniguchi, Masayuki; Lloyd, Douglas R.; Tanaka, Takaaki

doi:10.1016/j.memsci.2015.01.021

Cited by 43 publications

(34 citation statements)

References 26 publications

(41 reference statements)

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“…2(b)). Conversely, an were 10% and 20%, respectively, as expected from the phase diagram reported elsewhere 11) . Thus, the PLLA membranes with open finger-like pores and 500 µm thickness prepared from a 10% PLLA solution in 1,4-dioxane containing 15% Tween 80 were used in this study.…”

Section: Electron Dispersive X-ray Spectroscopysupporting

confidence: 86%

“…The cell density increased to 5000 6000 cells/mm 2 after 14 28 days of culture at which time the culture reached stationary phase. In comparison, the maximum cell density of Saos-2 cells has been reported to be 2000 3000 cells/mm 2 on culture flasks and dishes 11,15) . Therefore, the cells grew 2 3 times higher per unit apparent area in the PLLA membrane scaffold than in monolayer cultures.…”

Section: Electron Dispersive X-ray Spectroscopymentioning

confidence: 98%

“…PLLA membranes were prepared via the NIPS method similar to as reported elsewhere 11) . Typically, 5.00 g PLLA was dissolved in 38.25 g 1,4-dioxane con- …”

Section: Preparation Of Plla Membrane Scaffoldsmentioning

confidence: 99%

“…However, large cells such as human osteoblast-like cells (20 50 µm or larger) 10) are difficult to grow in these pores. Thus, the pore size on the inlet side should be larger than 100 µm to allow cells to grow in the pores and those on the opposite side should be smaller than 10 µm to retain the cells in the vent-induced phase separation (NIPS) method with the aid of surfactants 11) in a manner similar to that used for the preparation of poly(methyl methacrylate) membranes 12) . Surfactants, which exhibit hydrophiliclipophilic balance (HLB) values of 14.9 15.6, e.g.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

【Original Contribution】 Preparation of a Poly(L–Lactic Acid) Membrane Scaffold with Open Finger–Like Pores Prepared by a Nonsolvent–Induced Phase Separation Method with the Aid of a Surfactant

et al. 2016

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Section: Electron Dispersive X-ray Spectroscopysupporting

confidence: 86%

Section: Electron Dispersive X-ray Spectroscopymentioning

confidence: 98%

“…PLLA membranes were prepared via the NIPS method similar to as reported elsewhere 11) . Typically, 5.00 g PLLA was dissolved in 38.25 g 1,4-dioxane con- …”

Section: Preparation Of Plla Membrane Scaffoldsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

【Original Contribution】 Preparation of a Poly(L–Lactic Acid) Membrane Scaffold with Open Finger–Like Pores Prepared by a Nonsolvent–Induced Phase Separation Method with the Aid of a Surfactant

et al. 2016

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“…This phenomena is related to the velocity of precipitation of the system: the formation of macrovoids is mostly associated to instantaneous demixing, provided it allows the growth and coalescence of large nuclei of the polymer‐poor phase during liquid‐liquid demixing. The suppression of the formation of macrovoids in PLA systems due to delay in precipitation is also widely reported in the literature …”

Section: Resultsmentioning

confidence: 77%

Preparation of Poly(lactic acid) Flat Sheet Membranes by Liquid Induced Phase Separation

Domingues

Pereira

Borges

2016

Macromolecular Symposia

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Summary Biodegradable and biocompatible polymers have been evaluated as materials for membrane separation based processes due to their flexibility and highly aggregated value in biomedical, food and packaging applications. Polylactides is a promising class of biodegradable polymers mostly due to its mechanical properties and ease in processing. In this work, flat sheet Poly(L‐lactic acid) (PLLA) membranes were made by liquid induced phase separation (LIPS) technique using water as non‐solvent and N‐methyl‐2‐pyrrolidone (NMP) as solvent. Processing conditions as polymer concentration of the casting solution, time of exposure in humid atmosphere and composition of coagulation bath were evaluated. The effects of these variables were analyzed in the performance, morphology and mechanism of phase separation during membrane formation. The PLLA‐water‐NMP system miscibility gap was estimated by cloud points and viscosity of polymer solutions were measured. Membranes were characterized by precipitation kinetics by light transmission, hydraulic permeability and scanning electron microscopy. Porous microfiltration membranes could be formed with permeabilities of 62.87 L m−2 h−1. It could be concluded that the morphology of PLLA membranes is a result of a complex interplay between solid‐liquid and liquid‐liquid demixing during phase separation.

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Effect ofTween 80 on morphology and performance of poly(L‐lactic acid) ultrafiltration membranes

Jiang

Wang

Chen

et al. 2016

J of Applied Polymer Sci

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Poly(L‐lactic acid) (PLLA) ultrafiltration (UF) membrane was fabricated by immersion precipitation method using Tween 80 as an additive. Membrane structure was characterized by scanning electron microscopy (SEM), porosity and pore size measurement, and atomic force microscopy (AFM). Membrane performance was evaluated by pure water flux, molecular weight cut‐off, and tensile test. It was found that the addition of Tween 80 into the casting solution significantly increased the permeability and molecular weight cut‐off of membrane. Tensile test confirmed that the as‐prepared PLLA membranes exhibited acceptable mechanical properties for ultrafiltration. Further, the role of Tween 80 in the process of membrane formation was analyzed and proposed. The addition of Tween 80 favored the formation of larger pores by interrupting the polymer chain entanglement and improving the miscibility between solvent and coagulant. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44428.

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Preparation of poly(L-lactic acid) microfiltration membranes by a nonsolvent-induced phase separation method with the aid of surfactants

Cited by 43 publications

References 26 publications

【Original Contribution】 Preparation of a Poly(L–Lactic Acid) Membrane Scaffold with Open Finger–Like Pores Prepared by a Nonsolvent–Induced Phase Separation Method with the Aid of a Surfactant

【Original Contribution】 Preparation of a Poly(L–Lactic Acid) Membrane Scaffold with Open Finger–Like Pores Prepared by a Nonsolvent–Induced Phase Separation Method with the Aid of a Surfactant

Preparation of Poly(lactic acid) Flat Sheet Membranes by Liquid Induced Phase Separation

Effect ofTween 80 on morphology and performance of poly(L‐lactic acid) ultrafiltration membranes

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